Sentences with word «flavivirus»

The structure is mainly similar to that of other flaviviruses such as dengue virus; however, there are differences in a region that may be involved in binding to host receptors.

However this is the first report of flavivirus infection in ducks with a severe outcome and the future implications of such findings should be heeded.

The scientists also conducted the same study with dengue, which is from the same flavivirus family as Zika and is thought to share many characteristics with it.

According to the researchers, this latest work may now open new possibilities for intervention in flavivirus infection.

«These results support that the antibody - based assay that we have developed is highly effective in detecting both recent and past Zika virus infections and in discriminating Zika from other flavivirus infections,» said Davide Corti, senior vice president and chief scientific officer of Humabs BioMed.

Better diagnostic approaches are urgently needed, particularly ones able to differentiate cases of Zika from related flaviviruses such as dengue fever.

Zika virus (ZIKV), a mosquito - borne flavivirus with homology to Dengue virus (DENV), has become a public health emergency.

«It's the same technology WRAIR has used to successfully develop other flavivirus vaccines.»

For a better assessement of the established rRT - PCR, the specifity was tested with a variety of mosquito - borne and vertebrate - borne flaviviruses as described in Materials and methods.

The NS1 protein is produced by flaviviruses, like Zika, and released into the bloodstream of infected patients, where it interacts with the patient's immune system.

«In addition, this platform can be used to develop safe vaccine candidates for other flaviviruses such as Zika virus, where pregnant women are the target group for vaccination.»

Indeed, several succussful vaccines for flaviviruses have been developed and widely used (e.g., yellow fever virus and Japanese encephalitis virus), so a vaccine for BYDV may be feasible.

From preliminary epidemiology, pathogen isolation, and reproduction of the clinical disease by the isolated virus, BYDV, Koch's postulates were fulfilled, and a new flavivirus causing a serious duck disease was identified.

The structure of Zika virus is similar to other known flavivirus structures, except for the ~ 10 amino acids that surround the Asn154 glycosylation site in each of the 180 envelope glycoproteins that make up the icosahedral shell.

This is the first structure of any helicase bound to ATP from flaviviruses, a group including other well - known pathogens such as dengue, yellow fever, and West Nile viruses.

Dengue fever is caused by a mosquito - transmitted flavivirus resembling Zika virus.

Common symptoms of flaviviruses include fever, rash, joint paint, muscle aches, and headaches.

The epidemic strain produced elevated amounts of subgenomic flavivirus RNA (sfRNA), a viral noncoding RNA, relative to amounts of genomic viral RNA.

«Prior dengue or yellow fever exposure does not worsen Zika infection in monkeys: Findings counter some concerns that prior flavivirus disease primes immune system to enhance Zika infection.»

Zika virus - related neurotropic flaviviruses infect human placental explants and cause fetal demise in mice.

The research, published and featured in the Spot Light section of the December edition of the Journal of Virology, examines a previously unknown connection between flaviviruses — a classification of viruses that include West Nile virus, Dengue virus and tick - borne encephalitis virus — and organelles (a specialized subunit within a cell) known as peroxisomes that help coordinate the body's immune responses.

Zika's surface protein — the primary target of antibodies — looks extremely similar to those on dengue and West Nile virus, members of the same flavivirus family.

These findings have major implications for vaccines against flaviviruses.

The researchers say the culture model will greatly increase knowledge about how flaviviruses infect ticks and could become a tool to evaluate medical countermeasures against tick - borne viruses.

Two recent papers by a University of Colorado School of Medicine researcher and colleagues may help scientists develop treatments or vaccines for Dengue fever, West Nile virus, Yellow fever, Japanese encephalitis and other disease - causing flaviviruses.

The trial conducted at the WRAIR Clinical Trial Center in Silver Spring, Md., is assessing the impact of pre-existing flavivirus immunity in volunteers who had been vaccinated against yellow fever or Japanese encephalitis — both viral cousins to Zika — prior to receiving ZPIV.

The PR - 2B DENV - 2 produced increased levels of subgenomic flavivirus RNA (sfRNA) relative to genomic RNA during replication.

This is the first severe duck disease caused by a zoonotic flavivirus ever reported.

«Most flaviviruses are zoonotic,» meaning they can be transmitted from animals to people, Gao says, «so infection of human beings can not be ruled out.»

Thus, in vitro enhancement assays lacked the ability to predict flavivirus disease severity in the rhesus macaque model.

This new research tool (Figure 2) allows for the rapid analysis of biological specimens (serum, plasma, CSF, etc.) for high - throughput discovery of biomarkers that may be able to discriminate between these two very similar flaviviruses in a larger window after initial infection than currently possible.

Further, a newly emerging African flavivirus, Bagaza virus [18], both causes human illness [4], [19] and infects birds in Africa [20], [21].

In general, examining the potential effects of other flaviviruses on pregnant women and their developing fetuses is difficult, because outbreaks have been sporadic and less widespread than with Zika.

Jeffrey S. Kieft, PhD, associate professor of biochemistry and molecular genetics at the School of Medicine and an early career scientist with the Howard Hughes Medical Institute, and colleagues recently published articles in the scholarly journals eLife and Science that explain how flaviviruses produce a unique RNA molecule that leads to disease.

The NIAID scientists developed their model by dissecting three tick organs — the midgut, salivary glands and nervous tissue — and then culturing flaviviruses in those organs, evaluating their viability over several days.

Powassan virus and the closely related deer tick virus are the only flaviviruses known to be spread by ticks in North America.

What we learn from WNV may prove useful in the development of novel therapeutics for WNV and other more serious or newly emerging flaviviruses.

Flaviviruses impact a large proportion of the world's population.

While this is the first study comparing the effects in mice of these mosquito - transmitted and tick - transmitted viruses in parallel, Miner says, past studies have raised the possibility of fetal infections with other flaviviruses besides Zika.

Postdoctoral fellow Jaehwan You and PhD student Shangmei Hou, the lead authors on the study, found that flaviviruses induce degradation of a protein called Pex19, which is essential for the building of new peroxisomes, setting off a chain reaction that could leave the body more vulnerable to viral infection.

«Researchers are still working to understand precisely how Zika and other flaviviruses interact with an infected person's immune system,» she said.

This understanding of how an RNA found in many different flaviviruses thwarts a powerful enzyme may help scientists develop treatments or vaccines.

He says a rapidly spreading Chinese flavivirus could mean a global problem.

«Infection model developed for tickborne flaviviruses.»

WRAIR has been researching flaviviruses, a family of viruses that includes Japanese encephalitis, dengue, West Nile and Zika viruses, for over half a century.

There are already tests on the market, but none of them can tell the difference between these individual flaviviruses.

West Nile belongs to a group of viruses called flaviviruses, which includes yellow fever, dengue, and Japanese encephalitis.

The inactivated flavivirus vaccine platform was the same technology the Institute used to create its Japanese encephalitis vaccine, which was licensed in 2009.

Zika virus (ZIKV) is an arbovirus (Flaviviridae family genus flavivirus [1] transmitted by mosquitoes.

The NS5 protein coding regions of African ZIKV isolates were sequenced and aligned with representative flaviviruses sequences from GenBank to design primers and probe from conserved regions.