Sentences with phrase «flavivirus with»

Genomic sequencing of the isolated virus revealed that it is closely related to Tembusu virus (a mosquito - borne Ntaya group flavivirus), with 87 — 91 % nucleotide identity of the partial E (envelope) proteins to that of Tembusu virus and 72 % of the entire genome coding sequence with Bagaza virus, the most closely related flavivirus with an entirely sequenced genome.

Zika virus (ZIKV), a mosquito - borne flavivirus with homology to Dengue virus (DENV), has become a public health emergency.

Not exact matches

In general, examining the potential effects of other flaviviruses on pregnant women and their developing fetuses is difficult, because outbreaks have been sporadic and less widespread than with Zika.

Data used in the model consisted of information about the traits of flaviviruses — the family that includes Zika, yellow fever and dengue — and all the mosquito species that have ever been associated with them.

The new 3 - D structure, which was obtained using X-ray crystallography and electron microscopy, revealed that the outer surface of the Zika NS1 protein has substantially different electrical - charge properties than those of other flaviviruses — indicating it may interact differently with the members of an infected person's immune system.

Based on what they learned, they used the model to test the combination of Zika virus with all the mosquito species known to transmit at least one flavivirus.

«Researchers are still working to understand precisely how Zika and other flaviviruses interact with an infected person's immune system,» she said.

When the assay was run on patients infected with Zika virus and also on a control group of 540 patients infected by other flaviviruses or other viruses, plus healthy donors, the specificity was 95.9 percent.

None of the mothers reported being sick with Zika virus, but all four who were tested had antibodies to a flavivirus, the family to which Zika belongs.

The assay was implemented in five countries and tested using a large number of clinical samples from travelers and patients living in areas with a high level of exposure to Zika virus and other flaviviruses.

WRAIR is moving forward with the purified inactivated virus (PIV) vaccine, called ZPIV, because it builds on «a type of vaccine that has been licensed before,» said Col. Stephen Thomas, an infectious disease Army physician and a vaccinologist specializing in flaviviruses, and the WRAIR Zika program lead.

He conducted one of three monkey studies last year — two are on the internet but none has been published — that failed to find ADE in animals infected first with dengue or yellow fever (another flavivirus) and then Zika.

Studies suggest that Zika - induced antibody responses may also cross-react with other flaviviruses, particularly dengue virus.

The catch is that, although the antigens bind with the antibodies according to the lock and key principle, they almost always do so at the same site as all other flaviviruses.

The viruses» genetic similarity makes it possible to substitute a gene in one flavivirus's genome with the equivalent gene from another, creating a functional but nonpathogenic virus called a chimera.

The NS1 protein is produced by flaviviruses, like Zika, and released into the bloodstream of infected patients, where it interacts with the patient's immune system.

A near - atomic level map of Zika virus shows its structure to be largely similar to that of dengue virus and other flaviviruses, but with a notable difference in one key surface protein, report scientists funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

«The Army was able to move so quickly in developing, manufacturing and testing a Zika vaccine because of its extensive experience with this vaccine platform and long standing investments in the understanding and mitigation of flaviviruses, like yellow fever, dating back to the founding of WRAIR,» said Dr. Kayvon Modjarrad, Zika program co-lead and associate director for Emerging Infectious Disease Threats at WRAIR's MHRP.

A new research study from University of North Carolina researchers shows that individuals who have been previously infected with a flavivirus — specifically dengue and Zika viruses — could have antibodies that protect against Zika.

Given the concerns for immune enhancement with other similar flaviviruses, like yellow fever and Japanese encephalitis, ZPIV will be tested in some volunteers who will first be vaccinated against one of these other flaviviruses.

Shannon entropy analysis of the NS5 polymerase mature protein revealed that a G374E mutation, in a region that contributes to interferon resistance in other flaviviruses by interfering with JAK - STAT signaling was present in both the Asian and American sequences from the 2007 - 2008 Venezuelan outbreak, but was absent in the sequences from the 2001 Venezuelan outbreak.

However this is the first report of flavivirus infection in ducks with a severe outcome and the future implications of such findings should be heeded.

With frequent isolations, flaviviruses continue to threaten human health and animal industries.

We performed a systematic investigation, from epidemiology, pathogen isolation, virus characterization, disease reproduction by infection with the isolated virus (fulfilling Koch's postulates), to virus genome sequencing and found that the duck egg drop disease was caused by a new flavivirus, BYD virus, that is closely related to Tembusu virus.

The flavivirus genome, approximately 10.5 kb in size, encodes three structural proteins [capsid (C), membrane (PrM and M) and envelope (E)-RSB- and seven non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5) in one open reading frame with subsequent cleavage [9].

The high selectivity, and the potency with which some of these receptors promote flavivirus infection, suggest only a small number of receptors might be effectively targeted to treat these diseases.

The external face of the flavivirus NS1 protein (sugars in grey balls) is exposed on infected cell surfaces where it can interact with the immune system.