Not exact matches
Unfortunately, many other viruses from the same family, known as
flaviviruses, have similar versions of NS1 and can
produce a false positive.
The epidemic strain
produced elevated amounts of subgenomic
flavivirus RNA (sfRNA), a viral noncoding RNA, relative to amounts of genomic viral RNA.
The PR - 2B DENV - 2
produced increased levels of subgenomic
flavivirus RNA (sfRNA) relative to genomic RNA during replication.
«This is why, for our test, we
produced special antigens — using certain point mutations, we altered the area of the antigens that is the same for all
flaviviruses, effectively shutting it off.
The NS1 protein is
produced by
flaviviruses, like Zika, and released into the bloodstream of infected patients, where it interacts with the patient's immune system.
Conversely, current immune - based tests (e.g., the MAC ELISAs for ZIKV and DENV;
flavivirus Plaque Reduction Neutralization Tests),
produce cross-reactive results.