The biggest ever analysis of
flu strains shows the world's annual epidemic comes from the constant reservoir of bugs that follow the rainy season around East Asia
Not exact matches
Preliminary estimates by the federal CDC
show this year's version of the
flu vaccine is 36 percent effective against all
strains of the
flu, but just 25 percent effective against the H3N2
strain causing most
flu cases this winter.
The
flu vaccine is
showing higher effectiveness for H1N1 and influenza B
strains (67 and 42 % respectively for all age groups).
In recent years research has
shown that the mélange of
strains in each year's
flu shot and exposure to previous flus can provide some immunity decades later to people exposed to closely related influenza iterations.
New animations
show how various
strains of the
flu travel across the U.S. to mingle in the major hog production centers in the Midwest, suggesting strategies to monitor for future pandemics
A study published last March
shows that avian
flu strains can infect cells lining the human respiratory system, but they seem to have difficulty replicating.
Strains of the H7N9
flu virus (
shown) can mutate to become drug resistant and still maintain their ability to infect cells, a new study
shows.
This one - two punch protected the test subjects against influenza A viruses that had emerged in 1934 and 2007, and other experiments
showed that the antibodies it generated successfully neutralized a wide variety of
flu strains.
Writing in February in Vaccine, the researchers reported that the stored serum of elderly volunteers who received the vaccine in 2011
showed an immune response to new
strains of
flu that were circulating three years later.
All studies
showed the addition of the B
strain improved the antibody response to that
strain and didn't weaken the body's immune response to other
flu strains in the vaccine.
A triple reassortment
strain of an H1N2 virus, with genes from avian, swine and human
flu, has been
shown to jump easily via air to mammals
When they looked for the NS1 mutation in a national database, it
showed up in just 0.03 percent of all
flu strains reported.
Seasonal
flu strains such as H1N1 and H3N2 have
shown little resistance to the drug in adults, but two small studies have
shown resistance rates of up to 18 % in Japanese children (ScienceNOW, 26 August 2004).
Fortunately, studies so far have
shown that oseltamivir - resistant
strains don't replicate very well, says epidemiologist Arnold Monto, an expert in
flu drugs at the University of Michigan in Ann Arbor.
Investigators
showed the new strategy protected mice — vaccinated against the H3N2 influenza A
flu strain, which causes mild disease — from succumbing to the more dangerous H5N1 and H7N9
strains weeks later.
The paper focuses on two key molecular players in the story of influenza infection: a human protein called TRIM25, which was recently discovered to play an important role in the human immune response to
flu infection; and a protein called NS1 present in all
strains of the influenza A virus and
shown to bind TRIM25 to keep it from doing its job.
Genetic analysis
shows that the virus is a mix of avian and swine viruses from North America, a swine
flu strain usually seen in Asia, and a human influenza
strain.
Previously, Dr. Smeyne and his collaborator Dr. Stacey Schultz - Cherry in the Department of Infectious Disease at St. Jude Children's Research Hospital in Memphis, TN,
showed that a deadly H5N1
strain of influenza (so - called Bird
Flu) that has a high mortality rate (60 percent of those infected died from the disease) was able to infect nerve cells, travel to the brain, and cause inflammation that, the researchers
showed, would later result in Parkinson's - like symptoms in mice.
Building on that work, the current paper looked at a less lethal
strain, the H1N1 «swine
flu,» that does not infect neurons, but which, the researchers
showed, still caused inflammation in the brain via inflammatory chemicals or cytokines released by immune cells involved in fighting the infection.
The data they collect is shared with the CDC's Advisory Committee on Immunization Practices and led to the CDC's recommendation against LAIV last year after data from the two previous
flu seasons
showed it to be ineffective at preventing influenza A, which is typically the most common
strain.
September 14, 2016 New analysis explores the geographical origins of the
flu A computer model developed by UChicago's Sarah Cobey and her team
shows that small increases in transmission rates may lead to the spread of new seasonal
strains from east, south and southeast Asia.
Ahmedâ $ ™ s team had
showed that people infected by the 2009 H1N1
flu strain developed broadly protective antibodies, and separately, so did volunteers immunized against the H5N1 avian
flu virus.
The story, set in a near futuristic Japan,
shows the rise and sudden decline and rejection of dogs after a
strain of dog
flu threatens even humans and the dogs are sent from Megasaki City to a nearby «Trash Island.»
The
strain, which originated from a horse
flu, has stricken racing greyhounds and is
showing up in some pet dogs.