Not exact matches
Armed with that information, the
researchers then designed a mutant
flu strain that was powerful enough to replicate well but highly susceptible to our body's own ability to control the virus — the ideal ingredients for a
vaccine.
The
researchers are currently planning a follow - up study which will test whether a
flu vaccine is more effective for the elderly when combined with brief use of Losmapimod.
People using the patch had a similar immune response to the
flu vaccine as those who received a typical
flu shot,
researchers report online June 27 in the Lancet.
The hunt for a universal
flu vaccine, a single shot that would provide lifelong immunity, has been going on for decades, and many teams of
researchers have been on the case.
Researchers administered
flu vaccine to 141 pregnant women, 91 of whom received a
flu shot in the previous year, 50 who had not.
Each year, scientists create an influenza (
flu)
vaccine that protects against a few specific influenza strains that
researchers predict are going to be the most common during that year.
Studies that compare
flu alterations in multiple people won't immediately tell
researchers how to design
vaccines, she says, but could point to parts of the virus for further investigation.
Yoshihiro Kawaoka of the University of Wisconsin - Madison, lead
researcher on the other study, adds that the meeting allowed him and Fouchier to explain their work, including the potential benefits for surveillance of emerging
flu strains (Nature 481, 417 - 418; 2012) and for
vaccine preparation (Nature 482, 142 - 143; 2012).
Researchers could then reverse - engineer barcodes for the
vaccine, and thus the
flu itself, as well as other diseases.
The results of the early - stage
vaccine trial suggest that the preventive treatment should be developed further and that scientists are a step closer to being able to counter a potential H7N9
flu pandemic using a clinically tested
vaccine,
researchers argue April 30 in Science...
Writing in February in
Vaccine, the researchers reported that the stored serum of elderly volunteers who received the vaccine in 2011 showed an immune response to new strains of flu that were circulating three years
Vaccine, the
researchers reported that the stored serum of elderly volunteers who received the
vaccine in 2011 showed an immune response to new strains of flu that were circulating three years
vaccine in 2011 showed an immune response to new strains of
flu that were circulating three years later.
In the largest nursing home study to date on the effect of high dose
flu vaccine,
researchers found that shots with four times the strength of standard
flu shots significantly reduced the risk of being hospitalized during the influenza season.
However,
researchers are working to develop universal
vaccines that could protect against multiple
flu strains without needing to be updated.
During the 2012 - 2013 season, people who got a high - dose
vaccine were 36 percent less likely to die in the 30 days following hospitalization or an emergency department visit that included a
flu diagnosis compared to the standard - dose
vaccine, the
researchers found.
The
researchers are taking hemagglutinin mutations from every
flu strain that has ever circulated, dumping them into a kind of scientific blender and attaching them to particles that can form the basis of a
vaccine.
With no head in place to hoard the immune response, the
vaccine might coax the body to make enough stem - focused antibodies to protect against
flu, the
researchers hoped, regardless of the seasonal mutations occurring at the top.
Yale Cancer Center
researchers have developed a
vaccine strategy that reduces the risk of
flu infections in cancer patients at highest risk for influenza.
Some
researchers think the cytomegalovirus findings could explain why the elderly tend to respond poorly to the
flu vaccine.
Flu vaccine production is always a bit of a gamble, and, unfortunately, the strain the
researchers had chosen as a target wasn't the most virulent one roaming the U.S. that year.
The
researchers then exposed some of these strains to antibodies provoked by the current H3 seasonal -
flu vaccines.
The
researchers, led by Ram Sasisekharan, the Alfred H. Caspary Professor of Biological Engineering at MIT, also found that current
flu vaccines might not offer protection against these strains.
Instead,
researchers developed a
flu vaccine that ensures influenza viruses can't escape the body's first line of defense, a powerful antiviral system that enlists a cadre of immune proteins and cells.
The
researchers studied 4,193 pregnant women; about half of the subjects received a
flu vaccine; the other half received a
vaccine for meningitis.
Researchers around the world, including at the University of Rochester Medical Center (URMC), are pursuing a «universal»
flu vaccine, one that would protect against most or all seasonal and pandemic strains of the
flu virus.
The
researchers report mild side effects, such as swelling around the injection site and mild to moderate
flu symptoms in some participants within a week of getting the
vaccine.
When
flu researchers learned about this new sugar - adorned H3N2 virus in 2014, they made sure to include that strain in the 2016 — 17 seasonal
flu vaccine so that immunized individuals would mount an immune response against it.
If these genes were highly active before vaccination, an individual would generate a high level of antibodies after vaccination, no matter the
flu strain in the
vaccine,
researchers report online August 25 in Science Immunology.
The work, directed by
researchers at St. Jude Children's Research Hospital in Memphis, Tenn., found that some study participants who reported receiving
flu vaccines had a strong immune response not only against the seasonal H3N2
flu strain from 2010, when blood samples were collected for analysis, but also against
flu subtypes never included in any
vaccine formulation.
So the
researchers looked for a common genetic signal in blood samples from 175 people with different genetic backgrounds, from different locations in the United States, and who received the
flu vaccine in different seasons.
Researchers may need to monitor
flu evolution over more of the planet to match
vaccines to next winter's
flu.
The new finding will help
researchers formulate better
vaccines for future
flu seasons, the study's authors conclude.
The
vaccine targeted a
flu strain that didn't look like most of the strains traveling around the Northern Hemisphere during the 2014 - 2015
flu season,
researchers report June 25 in Cell Reports.
Researchers have developed new microneedle patches that can administer
flu vaccines without the pain of using regular shots.
Brown University
researchers found
vaccines well matched to the year's
flu strain significantly reduce deaths and hospitalizations compared to when the match is poor, suggesting that vaccination indeed makes a difference.
Researchers, led by Dr Gregory Poland and Dr Richard Kennedy from the Mayo Clinic, set out to examine how differences in an individual's immune cells correlate to their response to the seasonal
flu vaccine.
Many
researchers at NIH, universities and medical schools are looking for antibodies that act on a broad range of
flu strains, with the goal of understanding how they attach to the viruses and then designing
vaccines or other
flu therapies that produce a similar effect.
Rice
researchers seek better
vaccine procedure Technique would facilitate targeting
flu viruses
She noted that the Canadian
researchers estimated that the
flu vaccine is 55 percent effective against influenza B viruses, which typically cause more infections late in the season.
In a U.K. study published last year,
researchers looked at 276 senior citizens and found that those who got the
vaccine between 9 a.m. and 11 a.m. had a higher antibody response to two out of three
flu strains one month later than those who got their shot between 3 p.m. and 5 p.m.
In fact, a new report from
researchers of the University of Minnesota suggests that the
flu vaccine is not as effective as public health messaging suggests.
Even though the
flu vaccine was only 25 percent effective against the severe H3N2 strain that caused the most illness, the
vaccine could have been even less effective and still saved tens of thousands of lives, the
researchers said.
Researchers at the University of Birmingham in the United Kingdom, who studied married couples» antibody response to an influenza
vaccine, found that people in satisfying marriages had stronger immunity to
flu viruses.
Researchers have looked at why many people in these groups don't have their yearly
flu vaccine.