Inventions like the scanning tunneling microscope, the atomic force microscope, single -
molecule fluorescence techniques in biology and, going back further, the invention of scanning electron microscopes and transmission electron microscopes, has really revolutionized what can be done across a vast number of fields.
By
using fluorescence techniques, it was possible to measure the concentration of two markers of metabolism: the electron carrier NADH and the energy carrier ATP.
Cosa's research group specializes in single -
molecule fluorescence techniques, while Sleiman's uses DNA chemistry to design new materials for drug delivery and diagnostic tools.
Using
fluorescence techniques to pinpoint where the i - motifs were located, they identified numerous spots of green within the nucleus, which indicate the position of i - motifs.
Ongoing research thrusts include different advanced multiphoton and
fluorescence techniques, single - molecule approaches, pioneering near - field nano - imaging, plasmonics and nano - antenna approaches, Raman imaging, photothermal imaging, diffuse optical imaging, among others.