Due to the usage of lateral displacement, the nano - biomolecules can be detected in real - time and the detection is significantly faster in comparison to
fluorescent label based detection.
Not exact matches
Machines copy DNA strands and modify them with
fluorescent labels and other compounds to enable them to read DNA's sequence letters, or
bases.
This novel
fluorescent label - free approach uses the lateral shifts in the position of the microbead substrate in pillar arrays, for quantifying the biomolecules,
based on the change in surface forces and size, without the need of any external equipment.
Most colocalization methods are
based on pixel overlap between the previously denoised signal that is emitted from two (or more) different
fluorescent labels, and use a global image correlation such as Pearson's of Manders» coefficients.
However, we recently developed AAV (adeno - associated virus)-
based fluorescent labeling methods that can be used with 3DISCO to image non-transgenic animals such as rats (17).