Sentences with phrase «fluoride ion channels»

«With the structure now known, we can figure out exactly how fluoride ion channels work and how to control their function,» Koide said.

Monobodies were engineered to function as «crystallization chaperones» that stabilized and aligned fluoride ion channels so their structure could be determined.

Fluoride ion channels have only recently been discovered, and studies have hinted at an unusual structure that might explain their remarkable selectivity for fluoride.

The Fluc family of fluoride ion channels were recently discovered, and studies by a team led by Christopher Miller, PhD, HHMI Investigator and professor of biochemistry at Brandeis University, found that they are among the most selective channels yet identified.

«Monobodies are refined and powerful enough to attack important questions in biology and medicine, such as the structure of the fluoride ion channel, but they can also be used to generate molecules that are almost immediately useful in industry.

«Synthetic proteins help solve structure of the fluoride ion channel: Unexpected double - barreled «channsporter» structure suggests new mechanism for ion transport.»

For the fluoride ion channel, the surface area that is covered by detergent compounds proved to be too much for crystal formation to occur, due to the channel's small size and almost complete embedment within the membrane.

The researchers discovered that the fluoride ion channel is comprised of two major building blocks, which assemble together in an antiparallel manner.

To address this challenge, Koide, Miller and their teams designed monobodies that bound to target locations on the fluoride ion channel - specifically, two small surfaces not embedded within the cell membrane.

September 7, 2015 Synthetic proteins help solve structure of the fluoride ion channel Although present almost everywhere — food, soil, toothpaste and especially tap water — , the fluoride ion is highly toxic to microorganisms and cells.

Not exact matches

To avoid death, cells must remove fluoride that has accumulated inside them, a process accomplished via ion channels - protein tunnels through the cell membrane that only allow specific substances to pass through.