Intrigued by recent findings that neuron firing rates in the regions of mouse and
fly brains associated with visual processing increase during physical activity, UC Santa Barbara psychologists Barry Giesbrecht and Tom Bullock wanted to know if the same might be true for the human brain.
Not exact matches
So they engineered fruit
flies» genes to enhance or repress the activity of Rac in their
brains and taught them to
associate a smell with an electric shock.
Fruit
flies with the mutant form of LRRK2 also had a disrupted microRNA pathway
associated with the gene, and accumulated toxic proteins that killed motor - coordinating neurons in the
brain.
This area of the
fly brain is termed the mushroom body, and is
associated with motivation and learning.
But, as other researchers had seen, when Waddell's group boosted the levels of dNPF in the insects»
brains, the
flies beelined for the sugar -
associated odor, even if they had been allowed to eat.
The authors systematically analyzed a large number of
flies in which different patches of neurons lacked dati, and were able to map the rejection behavior to three distinct regions in the
brain, two of which had never been previously
associated with mating behavior.
CSHL
Associate Professor Glenn Turner and colleagues have now mapped the activity of
brain cells in the MB, in
flies conditioned to have Pavlovian behavioral responses to different odors.
But in their experiments with both
fly and human
brain cells made from patients with the ALS -
associated C9orf72 mutation, Rothstein and Lloyd discovered RanGAP is clumped up outside the nucleus.