Collins and Anthony James of the University of California, Irvine, thought they might use the mutant bug to test a fancy trick: Take a bit of DNA, called a transposon, that likes to wiggle into genomes, and use it to insert a fruit
fly gene for darker eye color into a mosquito's DNA.
Not exact matches
When Hawaii Islander Outfielder
Gene Locklear failed to run out a pop
fly for the second time in four days, Manager Roy Hartsfield suspended him, and Locklear spent three days on the bench without pay.
Gene drives enable a gene to spread rapidly through a population; there are plans to use them to combat mosquito - borne diseases by making the flies sterile or unsuitable as hosts for various viruses and parasi
Gene drives enable a
gene to spread rapidly through a population; there are plans to use them to combat mosquito - borne diseases by making the flies sterile or unsuitable as hosts for various viruses and parasi
gene to spread rapidly through a population; there are plans to use them to combat mosquito - borne diseases by making the
flies sterile or unsuitable as hosts
for various viruses and parasites.
The scientists compared the genetic sequence of five related strains of the species, looking
for orphan
genes and examining the life cycles of the various
genes in the
fly genome.
An exciting prospect
for the future involves the recovery of an entire system of clock - regulated
genes in organisms such as fruit
flies and mice.
«Knocking down the expression of this
gene is lethal
for fruit
flies — male and female,» said Anholt, who also directs NC State's W.M. Keck Center
for Behavioral Biology.
I was looking around
for insights when I came across the very thin literature on the
genes that sculpt fruit
fly bodies, including the study of spectacular mutants.
The
fly has orthologs to 177 of the 289 human disease
genes examined and provides the foundation
for rapid analysis of some of the basic processes involved in human disease.
NASA astronaut Peggy Whitson performed the
Genes in Space - 3 investigation aboard the space station using the miniPCR and MinION, developed
for previously
flown investigations.
In another group, the disabled
gene made it difficult
for fly brain cells to reinforce new connections that encode memories.
The same
gene network also plays a role in programming the
fly neurons responsible
for taste, the researchers report in the journal PLOS Genetics.
By comparing the genetic sequences of the mutant and normal
flies, the researchers found that the forgetful
flies had an inactive copy of a
gene that he and his Chilean collaborators dubbed Volado (Vol)-- South American slang
for absentminded.
In a series of experiments sparked by fruit
flies that couldn't sleep, Johns Hopkins researchers say they have identified a mutant
gene — dubbed «Wide Awake» — that sabotages how the biological clock sets the timing
for sleep.
Zwiebel and colleagues scanned the mosquito genome looking
for genes similar to those that generate fruit
fly odorant receptors, proteins that project from nerve cells and initiate a biochemical cascade when they encounter certain molecules in the air.
As the genomes of the two types of
fly mixed, those
genes responsible
for Dark -
fly's unique adaptations should become more common in the colony kept in the dark.
They found that one group of
flies, with a mutation in the
gene they would later call Wide Awake (or Wake
for short), had trouble falling asleep at night, a malady that looked a lot like sleep - onset insomnia in humans.
The study, conducted using fruit
fly populations bred to model natural variations in human sleep patterns, provides new clues to how
genes for sleep duration are linked to a wide variety of biological processes.
This longstanding testbed
for embryologists actually has more
genes in common with us than worms or fruit
flies do.
Now researchers have identified a single
gene, called fruitless (fru), as responsible
for the development of male sexual behavior in the
fly.
For instance, one protein produced by a key fruit
fly gene serves two separate functions over the course of
fly development.
When the scientists looked
for the human version of the newly identified
fly marker
for sleep deprivation, they found ITGA5 and realized it hadn't been among the human immune
genes they screened at the start of the study.
If a certain temperature is reached,
for example, the
genes within the modified spotted wing
flies would trigger its death.
The researchers analyzed the genetic control of a
gene responsible
for coordinating the formation of a simple structure in fruit
flies — a wing vein — during its development.
Researchers have known
for several years that when fruit
fly larvae metamorphose into adults, a
gene called fringe produces a protein that tells certain cells to become the wing margin, the leading edge of a developing wing.
To home in on the
gene responsible, evolutionary biologists Chung - I Wu and Chau - Ti Ting at the University of Chicago inserted progressively shorter pieces of DNA from one species, Drosophila simulans, into a
fly of another species, Drosophila mauritiana, and tested them
for fertility.
In their paper, the researchers suggest that actin might not be an ideal target
for crop protection,
for this reason — the house
fly's actin
gene is 80 per cent identical to the beetle's,
for example.
An accidental escape hinted at what those scents might be good
for: «When returning to the lab after a weekend, I found that a flask with a smelly yeast culture was infested by fruit
flies that had escaped from a neighboring genetics lab, whereas another flask that contained a mutant yeast strain in which the aroma
gene was deleted did not contain any
flies,» Verstrepen recalls.
«Sleep tight, fruit
fly: Scientists find
gene responsible
for sleep deprivation and metabolic disorders.»
Vosshall then turned to the mosquito genome to search
for genes akin to those of
flies.
Using the Drosophila melanogaster fruit
fly as a model organism, the team led by Prof. Dr. Ingrid Lohmann at Heidelberg University's Centre
for Organismal Studies was able to show how a special developmental
gene from the Hox family influences germline stem cells.
«So you could imagine if you are a
fly, preferences
for sugar, the tendency to store a lot of fat and the tendency to move less could all be contributing to the likelihood of being more obese if you have low levels of this
gene, or to be leaner if you have higher levels.»
One biotechnology company executive
flew from the United States to Colombia to try out her company's
gene therapy
for lengthening telomeres.
The big thing then (as now), Ruvkun says, was
for researchers to demonstrate that a
gene of interest exists in a spectrum of different species — from roundworms and fruit
flies to humans.
Says Kevin Fitzgerald, a worm researcher at Bristol - Myers Squibb, «Some of the same
genes and components that are responsible
for cancer, breast cancer
for instance, or Alzheimer's disease, are actually found, and they seem to function very similarly, in both worms and
flies.»
In nature, fruit
flies called «rovers» with high amounts of the
gene tend to move a lot, eat very little and stay lean, while
flies with low amounts of
for called «sitters» are the opposite.
When
flying isn't essential
for survival, the mutations that hinder flight can gradually accumulate in the
gene pool.
In 2004 Guilherme Neves and Andrew Chess, now at the Center
for Human Genetic Research at Massachusetts General Hospital, tracked the roles played by other
genes on chromosome 21 — in this case using a fruit
fly as the model.
«In model organisms, like yeast or
flies, scientists often generate mutations to determine which letters in a DNA sequence are needed
for a particular
gene to function,» explains CSHL Professor Adam Siepel.
They compared space -
flown endothelial cells to endothelial cells cultured under normal gravity, looking
for differences in
gene expression and / or in the profile of secreted proteins.
In order to find the
genes that guide that migration, geneticist Ruth Lehmann of the Howard Hughes Medical Institute at New York University Medical School and her colleagues used chemicals to cause mutations in thousands of adult fruit
flies then screened their embryonic offspring
for lost or misguided germ cells.
A team of biologists led by Gerald Wilkinson of the University of Maryland, University Park, studied a type of Malaysian
fly, called Cyrtodiopsis, with a strange genetic battle being waged inside its body: To perpetuate themselves,
genes on the
fly's X chromosome code
for proteins that kill sperm carrying a Y chromosome.
In worms, mice and
flies,
for instance, researchers have radically extended lifespan by suppressing
genes involved in growth - factor signalling, or by restricting food.
To get around this problem, neurobiologists Susana Lima and Gero Miesenböck of the Yale University School of Medicine in New Haven, Connecticut, inserted a
gene that codes
for a rat ion channel into Drosophila fruit
flies.
To see what
genes might be involved in this increased aggression, the team used microarrays to look
for differences in
gene expression in
fly brains.
The scientists sifted through the collection looking
for mutant
flies with walking impairments and soon zeroed in on several impaired walkers that turned out to have mutations in the same
gene.
The researchers used this live - imaging technique to study
fly embryos at a key stage in their development, approximately two hours after the onset of embryonic life where the
genes undergo fast and furious transcription
for about one hour.
In spite of the difference between the cell functions responsible
for giving rise to a tumour and
for the metastasis of this same tumour, studies at IRB Barcelona using the
fly Drosophila melanogaster reveal that some
genes can drive both phenomena.
A regulatory factor called Dorsal controls a network of
genes crucial
for development of fruit
fly embryos.
Roughly 75 % of disease - causing
genes in humans are also found in the fruit
fly, and most of the components found in human heart cells are also found in the
fly heart, thus providing a model
for studying cardiovascular changes.
The FOXO
gene is important
for longevity in a wide variety of species, including yeast,
flies, worms and humans, so the team say the findings may have broad implications.