Sentences with phrase «foam cells»
Rodriguez had already observed how HDL pulls cholesterol out of foam cells, which are found in the plaque that accumulates on blood vessel walls in people with atherosclerosis.
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«We would take foam cell [models] and make them chock full of cholesterol, put HDL outside the cell, and see how well cholesterol was moving out of the cell — the more HDL the better,» Rodriguez recalls.
The only other one that comes to mind is the SENS foundation's development of an enzyme for removing oxidized cholesterol from foam cells.
Western - type diets containing moderately high levels of SF (~ 35 kcal % fat,), as (cocoa butter, palm oil, or dairy butter), cholesterol (~ 0.5 to 1 % w / w) and cholic acid (~ 0.1 % to 0.5 % w / w), are capable of inducing elevations in TC and LDL - C and mild atherosclerosis (i.e. cholesterol laden foam cells, fatty deposits or streaks) in some mouse strains after 12 weeks (14 - 16).
Atherosclerosis is initiated by high plasma cholesterol leading to monocyte entry into the artery wall and differentiation into macrophages, which take up lipoprotein cholesterol to become lipid engorged foam cells.
Over time, these white blood cells, known as foam cells, begin to invade the linings of arteries, causing further arterial damage and obstructing blood flow.
Effects of conjugated linoleic acid isomers on monocyte, macrophage and foam cell phenotype in atherosclerosis.
The insulin causes the initial injury to the vessel wall, then the cascade of events ie macrophages ingesting LDL particles, foam cells etc are secondary reactions.
The longer cholesterol stays high the more prone it is to oxidisation, the more oxidised it becomes the greater the propensity to induce foam cell production and arterial occlusion as a result of inflammation.
Senescent intimal foam cells are deleterious at all stages of atherosclerosis.
If the oxLDL / LOX -1 internalization occurs in a monocyte, the macrophage is phenotypically transformed into the classic «foam cell», which is the sine qua non of atherosclerosis.