Sentences with phrase «focused on cancer cells»

A second hurdle in cancer is to generate an immune response sharply focused on cancer cells while avoiding normal cells and tissues.

After completing her graduate studies in 2006, she joined the laboratory of Dr. Craig B. Thompson at the University of Pennsylvania for postdoctoral work focusing on cancer cell metabolism.

Not exact matches

The Parker Institute for Cancer Immunotherapy will focus on the emerging field of cancer immunotherapy, which harnesses the body's immune system to fight cancer Cancer Immunotherapy will focus on the emerging field of cancer immunotherapy, which harnesses the body's immune system to fight cancer cancer immunotherapy, which harnesses the body's immune system to fight cancer cancer cells.

Biotech giant Gilead Sciences is beefing up its cancer drug portfolio with a $ 11.9 billion deal to buy Kite Pharma, a company focused on a groundbreaking new class of treatments that turns the body's own immune cells into targeted blood cancer killers.

The Napster founder and former Facebook president created the Parker Institute for Cancer Immunotherapy, which will focus on using the body's immune system to combat cancer Cancer Immunotherapy, which will focus on using the body's immune system to combat cancer cancer cells.

His research has spanned hematopoiesis, gene therapy, stem cell biology, genomics and cancer, consistently focusing on bringing the very latest research advances to patients with heretofore incurable diseases.

Investigators have repeatedly touted the drug as a potential lynchpin in immuno - oncology, focusing on an enzyme that suppresses the immune cells Opdivo and a whole new class of PD - 1 / L1 checkpoints are designed to unleash in an attack on cancer cells.

When cells are focused on making that wonderful, nutritious, delicious milk for babies, they are less likely to develop cancer.

The lab that I work in is primarily interested in understanding how and why certain cancers are more likely to spread to the skeleton, and my personal project has focused on uncovering new mechanisms that the cancer cells use to communicate with other cells in the bone.

Joe W. Ramos, PhD, deputy director of the UH Cancer Center and collaborators focused on investigating how these oncogenes and related signals lead to dysregulation of normal processes within the cell and activate highly mobile and invasive cancer cell behCancer Center and collaborators focused on investigating how these oncogenes and related signals lead to dysregulation of normal processes within the cell and activate highly mobile and invasive cancer cell behcancer cell behavior.

But an announcement on the website of Shenzhen's Dapeng New District, where the center is located, makes one mention of cancer cell immunotherapy, while identifying «precision medicine» as a main focus.

«Current therapies in clinical trials are focused on targeting genetic changes in tumors and helping to boost one's immune system to fight the cancer cells.

The researchers focused on three types of skin cancer: cutaneous melanoma, basal cell carcinoma and squamous cell carcinoma.

The study, published April 4 in the journal The Lancet Oncology, focused on non-small cell lung cancer, which is the most common form of lung cancer.

«For years, researchers have focused on delivering more chemotherapy drugs into cancer cells using nanoparticles, without targeting the root of drug resistance,» He said.

«As scientists, we have focused a good deal of attention on understanding the role of stem cells in the development of cancers, but there hasn't been a focus on mature cells,» said senior investigator Jason C. Mills, MD, PhD, a professor of medicine in the Division of Gastroenterology.

Future research should not only compare how embryonic stem cells, iPS cells and adult stem cells differentiate, but focus on what effects the niche in which these cells will reside, when transplanted, will have on their characteristics, including tendencies to mutate into cancer cells, notes cell and stem cell biologist Olga Genbacev at the University of California, San Francisco, (U.C.S.F.) School of Medicine.

At first it was thought that only functioned as cellular debris warehouses but in recent years has been that could have an important role as a messenger between cells of the body and now many groups focus their research on the role that could be played exosomes in various diseases, including cancer.

EMD Serono, Kirschbaum says, «focuses on the development of targeted cancer therapies on three therapeutic platforms: targeting the tumor cell, the tumor environment, and the immune system.»

«It was kind of fun being at a medical school and known as the weird guy who worked with dogs,» says Modiano, who is now a professor of comparative oncology at the University of Minnesota College of Veterinary Medicine and the Masonic Cancer Center, where his research focuses on immunology, cancer cell biology, cancer genetics, and applications of gene thCancer Center, where his research focuses on immunology, cancer cell biology, cancer genetics, and applications of gene thcancer cell biology, cancer genetics, and applications of gene thcancer genetics, and applications of gene therapy.

Kornelia Polyak, an oncologist at Harvard Medical School in Boston, says that cancer researchers tend to focus on the mutations inside cells, and fail to consider how those mutated cells might influence the cells around them.

So Swanton is focusing on immunotherapies — strategies that help the immune system to recognize and destroy cancer cells.

For this study, Nakano and his collaborators used cancer cells from 40 patients with high - grade gliomas, focusing on tumor cells with a stem - cell signature.

To see whether cancer stem cell renewal involves a chain of events similar to that used by embryonic stem cells, and whether the process was affected by oxygen levels, Semenza and graduate student Chuanzhao Zhang focused their studies on two human breast cancer cell lines that responded to low oxygen by ramping up production of the protein ALKBH5, which removes methyl groups from mRNAs.

Lead author Moustafa Abdalla writes: «Almost all genomic studies of breast cancer have focused on well - established tumours because it is technically challenging to study the earliest mutational events occurring in human breast epithelial cells.»

They elaborate on several focus areas described by the White House earlier: preventive vaccines, early detection, single cancer cell genomics, immunotherapy, pediatric cancer, and data sharing.

Organic synthesis is a scientific discipline central to the drug discovery process that is focused on building new carbon - based molecules that can affect biology — for example, targeting and destroying cancer cells.

As a doctoral student in the lab of Drs. Margaret Wheelock and Keith Johnson at the University of Toledo, Dr. Islam focused on identifying a link between cadherins (a family of cell adhesion proteins) and tumorigenesis (start of cancer cell formation).

She helped lead a GSK project focused on designing a monoclonal antibody to link to the HER3 receptor on human cells as a treatment for cancer.

It also focuses more narrowly on cancer cells, so that far fewer healthy cells are killed,» she says.

Currently, in another study, the researchers are focused on detecting circulating tumor cells in the blood of patients with a diagnosis of breast cancer.

Other possible ways to attack pancreatic cancer cells focus on taking away their ability to hide from the immune system.

In particular, his laboratory focuses on the regulation of key signaling networks that regulate cancer cell growth and survival.

«Although right now we are focusing on developing a cancer vaccine, in the future we could be able to manipulate which type of dendritic cells or other types of immune cells are recruited to the 3D scaffold by using different kinds of cytokines released from the MSRs,» said co-lead author Aileen Li, a graduate student pursuing her Ph.D. in bioengineering at Harvard SEAS.

For several years, the research team from the Turku Centre for Biotechnology lead by Professor Johanna Ivaska has focused their efforts on understanding how cancer cells move and invade surrounding tissue.

In the new study, Burrows and colleagues focused on the protein HIC1, or «Hypermethylated in cancer 1, «so named because it was first identified in cancer cells; however, it also helps regulate gene expression in normal cells.

In a study described in the January 13 issue of Cancer Cell, Marikki Laiho, M.D., Ph.D., and her colleagues say their work focused on the ability of a chemical dubbed BMH - 21 to sabotage the transcription pathway RNA Polymerase pathway (POL I), shutting down the ability of mutant cancer genes to communicate with cells and replCancer Cell, Marikki Laiho, M.D., Ph.D., and her colleagues say their work focused on the ability of a chemical dubbed BMH - 21 to sabotage the transcription pathway RNA Polymerase pathway (POL I), shutting down the ability of mutant cancer genes to communicate with cells and replcancer genes to communicate with cells and replicate.

In an effort to unravel that mystery, Rodriguez and his colleagues focused on the ways those cancer cells regulate the expression of genes or whether they make their constituent proteins.

«The focus of chemotherapy and existing standard - of - care is on killing cancer cells but instead we took a completely different approach which changes the environment the cancer cells live in,» said Mick Bhatia, director and senior scientist with the McMaster Stem Cell and Cancer Research Institute, who led the group that performed the cancer cells but instead we took a completely different approach which changes the environment the cancer cells live in,» said Mick Bhatia, director and senior scientist with the McMaster Stem Cell and Cancer Research Institute, who led the group that performed the cancer cells live in,» said Mick Bhatia, director and senior scientist with the McMaster Stem Cell and Cancer Research Institute, who led the group that performed the Cancer Research Institute, who led the group that performed the study.

But there's a great deal of overlap: For example, CRISPR Therapeutics and Editas have both made sickle cell disease and Duchenne muscular dystrophy a priority, and Intellia and Editas both have programs targeting the liver disease α - 1 antitrypsin deficiency and collaborations that focus on engineering T cells to fight cancer.

«Current cancer treatment often focuses on targeting cancer cells, but is not focused on targeting the fibrotic connective tissue, that may develop first, before you have cancer.

«This is a significant example of how knowing details of potential mechanisms and the basic science of redox active compounds in cancer versus normal cells can be leveraged clinically in cancer therapy,» says co-senior author Douglas Spitz, who focused on the biochemical studies.

«Most effort in the past has been studying cancer cells and tumors themselves, but we're focusing on what precedes the tumor,» Backman says.

The study focused on squamous cell head and neck cancers, a scourge among those who use tobacco and alcohol.

The screening revealed coibamide A to be capable of killing many types of cancer cells, but Ishmael decided to focus subsequent studies on two types in particular — brain tumors, or glioblastomas, and a breast cancer subtype known as triple negative breast cancer.

The findings, published Feb. 10 in the journal Cancer Cell, raise hopes that treatment strategies that focus on both enzymes simultaneously could help bring molecularly targeted treatments to AML, a common blood cCancer Cell, raise hopes that treatment strategies that focus on both enzymes simultaneously could help bring molecularly targeted treatments to AML, a common blood cancercancer.

In the study, Shen's group focused on a microRNA called miR - 34a that gives cancer stem cells the odd ability to divide asymmetrically.

Given his training in developmental biology, Raman focused the team to seek a novel drug target on genes important to the development of model organisms — fruit flies (Drosophila) and yeast (Saccharomyces cerevisiae)-- rather than on oncogenes that transform a normal cell into a cancer cell.

The study focused on pancreatic ductal adenocarcinoma (PDA), a lethal form of cancer known to come with an influx of immune cells into tumors.

Dr. Sadelain's research focuses on human cell engineering and cell therapy to treat cancer and hereditary blood disorders.