Cancer studies have increasingly
focused on chromatin — the intertwined proteins and DNA that are packaged into chromosomes — because of its ability to regulate genes important for either activating or inhibiting tumorigenesis.
Over the years his research has
focused on chromatin structure, its modifications and their role in gene regulation, and he has partnered to publish, in his career, over 153 papers.
Not exact matches
«We may need to
focus on drugs that modify
chromatin in a way that decreases methylation,» Grayson says, to «turn
on genes that are missing in the schizophrenia.»
The initial work was mainly
focused on the study of the regulation of muscle
chromatin and gene expression by motor innervation.
The laboratory's interest is the stress response and the interplay between DNA repair and other cellular processes including transcription and
chromatin remodeling, and is
focused on elucidating the function and mechanochemistry of DNA - based motors using a combination of biochemical, biophysical and structural techniques.
The CCP also
focuses on deciphering the regulatory circuit that controls
chromatin organization and maintenance in various stem cell types to determine their functional influence
on a cell expression signature and phenotype.
We
focus on how changes in
chromatin structure orchestrate the developmental transitions from fertilization to genome activation to cell fate specification.
Our laboratory will
focus on applying new synthetic and chemical biology methods to understand
chromatin structure and function.
Steve's research
focuses on polyploid crops where he uses genomics and bioinformatics approaches to examine
chromatin structure and the effect it has
on gene regulation.
In order to address this question, we
focus on the Nodal signaling pathway and analyze the
chromatin profile of its target genes during the transition from pluripotency to fate specification.
My lab is
focused on investigating the mechanisms by which
chromatin modifier gene mutations contribute to the initiation and progression of urothelial carcinomas of the bladder and upper tract.
His laboratory
focuses on the roles of reversible protein modifications that are involved in modulating signal transduction,
chromatin dynamics and gene activation.