Sentences with phrase «focuses on human cell»

Dr. Sadelain's research focuses on human cell engineering and cell therapy to treat cancer and hereditary blood disorders.

Not exact matches

Her PhD is focused on developing a novel label - free imaging approach for assessing human stem cells and skeletal regeneration non-destructively and non-invasively.

Her group will focus on the biogenesis and homeostasis of mitochondrial proteins and add mammalian and human cell lines to current yeasts.

«Most previous research into ways of delaying the onset of HD symptoms have focused on studying the mutant protein in cells or in animal models, but the relevance of abnormalities in those systems to what actually happens in patients remains a huge assumption,» says James Gusella, PhD, director of the Center for Human Genetic Research (CHGR) at Massachusetts General Hospital (MGH), corresponding author of the Cell paper.

This is in stark contrast to much previous work, which has focused on human embryonic stem cells, or hESCs.

Biotech's latest mantra is «proteomics,» as it focuses on how dynamic networks of human proteins control cells and tissues

«By identifying this major regulator of noncoding editing in C. elegans we can now focus on dissecting the regulatory mechanism and determining the conservation of this regulatory protein in human cells.»

To see whether cancer stem cell renewal involves a chain of events similar to that used by embryonic stem cells, and whether the process was affected by oxygen levels, Semenza and graduate student Chuanzhao Zhang focused their studies on two human breast cancer cell lines that responded to low oxygen by ramping up production of the protein ALKBH5, which removes methyl groups from mRNAs.

Lead author Moustafa Abdalla writes: «Almost all genomic studies of breast cancer have focused on well - established tumours because it is technically challenging to study the earliest mutational events occurring in human breast epithelial cells.»

She helped lead a GSK project focused on designing a monoclonal antibody to link to the HER3 receptor on human cells as a treatment for cancer.

The researchers focused on one common epigenetic process known as methylation, in which methyl (CH3) groups attach in various patterns to the genes of human cells.

The approach developed by the MGH team focuses on small areas of the human genome — so - called polyguanine (poly - G) repeats that are particularly susceptible to mutation, with genetic «mistakes» occurring frequently during cell division.

The group focused its efforts on human pluripotent stem cells, which can become all of the body's tissues.

(Fan says that his team is now focusing on improving the efficiency of CRISPR using human stem cells).

«This study focused on the development of the neocortex, but we aim to analyze multiple brain regions and developmental stages to achieve a more comprehensive atlas of cell types in the developing human brain,» Kriegstein said.

«Our focus here has been on early heart development, but the basic principles of patterning of human pluripotent stem cells, and subsequently differentiating them, can be readily expanded into a broad range of tissues for understanding embryogenesis and tissue morphogenesis,» said Healy.

This new understanding allows us to focus on how to make this molecule less toxic to human cells.»

Sergey Nikolaev from the UNIGE Faculty of Medicine focused on Basal Cell Carcinoma (BCC), a type of cancer that is very common in humans.

It is a continuation of previous research, published in 2011, that focused on the effect of decitabine on glioblastoma human cell cultures.

A better strategy might be to focus on how human cells offer influenza a cozy home.

Treatment has focused on electronic devices like hearing aids or cochlear implants because once lost, human auditory hair cells do not grow back.

«Our focus here has been on early heart development, but the basic principles of patterning of human pluripotent stem cells, and subsequently differentiating them, can be readily expanded into a broad range of tissues for understanding embryogenesis and tissue morphogenesis,» said Dr. Healy.

Much of the bioethics focus has been on what would happen if an animal had enough human brain cells to think and feel like a person — but a person inside the body of a monkey, pig, rat, or mouse.

Lanza's research focuses on the use of stem cells and regenerative medicine including nuclear transfer and stem cells in human transplantation.

The group's objectives are focused on using neural progenies of human Pluripotent Stem (hPS) cells to understand and develop new treatments for Huntington Disease (HD).

We will develop novel CD8 + T - cell - inducing adjuvants, focusing on stability, characterisation, pharmaceutical acceptability, and optimal vaccination strategies (route, prime / boost) with the overall aim of providing adjuvants and strategies for effective CD8 + T - cell induction, suitable for human clinical testing.

NeuroStemcell is focused on the identification and systematic comparison of progenitor cell lines with the most favourable characteristics for mesDA and striatal GABAergic neuronal differentiation, generated either directly from human embryonic stem (ES) cells, from Neural Stem (NS) cells derived from ES cells or fetal brain, from induced Pluripotent Stem (iPS) cells or from in vitro short - term expanded neural progenitors from ventral midbrain grown as neurospheres (VMN, Ventral Midbrain Neurospheres) 4, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animals models.

To improve the technique, they focused on gold nanoparticles — spheres only 20 nanometers in diameter, more than 300 times smaller than a human blood cell.

Peter and colleagues focused their initial studies on a standard panel, known as NCI60, of 60 human tumor cell lines that can genetically be divided into two large groups, which they called superclusters 1 and 2.

Scientists working at the Center focus on applying the pioneering the principles of stem cell biology for the advancement of human health.

That study found that since MSCRF first began awarding grants in 2007, its pattern of giving shifted over the years from strongly favoring projects focusing on ethically contentious human embryonic stem cell research (hESCR) to projects focusing on ethically non-contentious adult stem cells and other non-embryonic stem cell research.

His research is focused on retinal regeneration by reprogramming human fibroblasts either into induced pluripotent stem cells or directly into photoreceptors.

AFM study shows prominent physical changes in elasticity and pericellular layer in human acute leukemic cells due to inadequate cell - cell communication This article appears in the collection Nanotechnology Focus on Scanning Probe Microscopy Presenter: Igor Sokolov

She is registred to the National Order of Biologists in the province of Palermo; collaboration in research project from 2012 to 2015 at the Department of Biopathology and Biotechnology, University of Palermo, focusing the study on the identification of molecules capable to modulate intracellular metabolic pathways for the prevention and treatment of infectious, tumor and degenerative disease, in collaboration with Prof. Angela Santoni, University of Rome; collaboration in research project in 2011 at the hospital «Villa Sofia Cervello» of Palermo to study methods can cure the genetic defect that causes thalassemia through genetic engineering; she studies different mechanisms of the differentiation and the activation of human gammadelta T cells as effector cells of the immune response against cancer and infectious diseases; she investigates about the identification and development of biomarkers of resistance and susceptibility to Mycobacterium tuberculosis infection; Valentina Orlando has published 13 papers in peer reviewed journals and 3 comunications at national and international congress.

Prof. Caccamo's research is focused on the role of human T cell subsets in physiology and in pathology, on the role of human T lymphocytes during M. tuberculosis infection and on the identification, optimization and evaluation of correlates of protection and tuberculosis disease.

iTeos focuses upon selected key suppressive mechanisms of immunity in cancer based on gene expression, association with immune cell subsets, protein expression in human tumors and biological validation.

The HTS at I - Stem focuses on relevant biological models of genetic diseases: the human stem cells and their progenies.

His motivation to gain broad experience in several immunological methods and to understand the vast immunological scenarios, in combination with the deep expertise in T cell characterization is paving the road for him to chase a career in scientific research focused on understanding and developing better strategies to efficiently tackle human diseases.

The Swedish part of the effort, called the Human Developmental Cell Atlas (HDCA) program, includes researchers from Karolinska Institutet, Stockholm University and KTH, focusing on brain, lung, heart and fetal development during the first 12 -LSB-...]

In particular, this meeting will focus on addressing the technological challenges and opportunities presented by the Human Cell Atlas in areas including large - scale single - cell RNA sequencing, spatially - resolved methods, single - cell proteomics, epigenomics, and sample handlCell Atlas in areas including large - scale single - cell RNA sequencing, spatially - resolved methods, single - cell proteomics, epigenomics, and sample handlcell RNA sequencing, spatially - resolved methods, single - cell proteomics, epigenomics, and sample handlcell proteomics, epigenomics, and sample handling.

We have focused on the less - studied replacement of astrocytes, the major support cell in the central nervous system, by generating astrocytes from embryonic human glial precursor cells using two different astrocyte differentiation inducing factors.

Once taken up by antigen - presenting cells, which help focus the immune system on an invader, the vaccine releases a factor that heightens their attention specifically to the cancer - promoting protein E7, a so - called oncoprotein that not only enables the human papillomavirus to multiply, but potentially cervical cancer cells to do the same.

Research Focus: My research project is focused on the characterization of human T cell immune responses against Dengue virus.

Sten Orrenius» research has focussed on Cell Biology and Molecular Toxicology, most recently on mechanisms of apoptosis and other modes of cell death and the implications thereof for human diseCell Biology and Molecular Toxicology, most recently on mechanisms of apoptosis and other modes of cell death and the implications thereof for human disecell death and the implications thereof for human disease.

2/20/2007 Seven at UC San Diego Receive Stem Cell Funding from California Institute for Regenerative Medicine (CIRM) Dr. Leon Thal of UC San Diego honored with naming of statewide SEED grants More than two years after voters approved a $ 3 billion program to fund stem cell research in California, the state has approved the first grants focused solely on human embr... MorCell Funding from California Institute for Regenerative Medicine (CIRM) Dr. Leon Thal of UC San Diego honored with naming of statewide SEED grants More than two years after voters approved a $ 3 billion program to fund stem cell research in California, the state has approved the first grants focused solely on human embr... Morcell research in California, the state has approved the first grants focused solely on human embr... More...

The I - Stem laboratory is an institution dedicated to the exploration of potential therapeutic applications of human ES and iPS cells and therefore, is rather a scientific center focusing on «Research and Development».

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

The project focuses on the study of human breast cancer cells, particularly if and how CNPs can target and deliver medication to specific cells.

In particular, this meeting focused on addressing the technological challenges and opportunities presented by the Human Cell Atlas in areas including large - scale single - cell RNA sequencing, spatially - resolved methods, single - cell proteomics, epigenomics, and sample handlCell Atlas in areas including large - scale single - cell RNA sequencing, spatially - resolved methods, single - cell proteomics, epigenomics, and sample handlcell RNA sequencing, spatially - resolved methods, single - cell proteomics, epigenomics, and sample handlcell proteomics, epigenomics, and sample handling.

Three recent experimental studies focused on low consumption / exposure.949596 In one study, 29 smokers each consumed a single cigarette, immediately after which they had a significant decrease in blood vessel output power and significant increase in blood vessel ageing level and remaining blood volume 25 minutes later, as markers of atherosclerosis.94 In another study, human coronary artery endothelial cells were exposed to the smoke equivalent to one cigarette, which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.96