Sentences with phrase «focuses on variant»

The fund's approach to investing is described as: «We are a value - based, catalyst driven investor, focused on a variant perception of company fundamentals.

Not exact matches

; 2) a variant that focused on behavior, «Did you do your best to be happy today?»

But it was the variant that focused on personal behavior that «really hit it out of the park,» says Goldsmith...

To support the renewed focus on the apple segment, Magners will be focusing primarily on its Original apple variant.

This class will focus on India Pale Ales, spotlighting their history, flavor and aromatic attributes, as well as the many diverse variants that represent the style.

All four teams focused their hunts on gene variations found in at least 10 per cent of the population, while Stefánsson thinks that rarer variants may play a more significant role in menarche.

Although the world's attention is focused on the novel H1N1 virus causing the swine flu pandemic, H3N2, a seasonal strain of influenza, has popped up in many East Asian countries — and some variants in circulation may outfox the seasonal vaccine in use.

The new study focused on 40 cognitively healthy older adults between the ages of 65 and 75 who are carriers of a gene variant (APOE e4) that is known to contribute to the risk of developing late - onset Alzheimer's disease.

He has worked in the biotech industry as a research scientist for over 11 years with a focus on emerging technologies including gene targeting in mice, molecular analysis of transgenes using GFP variants at the single cell level, and developing flow cytometry reagent kits to speed up assay development time for researchers.

GenProfile focuses on the systematic analysis of DNA sequence variation in biomedically relevant genes in order to identify those variants, or combinations of variants (gene profiles), that determine an individual's genetic risk for disease, predict individually different drug response, and ultimately pave the way to a personalized medicine.

By focusing on several of these mutations and screening through guide RNA variants with different mismatch combinations, they were able to identify specific guide RNAs that stimulated Cas9 activity towards the mutated gene sequences but left the normal counterpart untouched.

It used data from 327,288 people and focused on rare genetic variants.

Ishii and his team chose to focus on two histone variants named TH2A and TH2B, known to be specific to the testes where they bind tightly to DNA and affect gene expression.

«If we find additional variants, we may be able to develop a tool that identifies diabetic patients who are at increased risk of developing CHD and focus on preventing the disease in these people,» says Dr. Doria.

For instance, it focused entirely on people of European descent, so there's no telling whether the same genetic variants would be found in people of other ethnicities.

Current projects focus on air pollution, occupational exposures such as shift work, biomarkers such as melatonin, vitamin D, and sex hormones, and other factors such as physical activity, and genetic variants.

Discrimination against entire subgroups could also occur if, for example, genetic variants were found to correlate with a more favorable vaccine or treatment response, but only in certain ethnic groups; also, drug development might focus on these «more responsive subgroups.

The alliance will initially focus on the development, validation and commercialization of specific diagnostic tests for variants in genes involved in three disease - related pathways:

Glaxo would later halt one study focused on a resveratrol variant that led to complications.

The most common approach is to focus on protein - truncating variants or PTVs (sometimes also called loss - of - function variants *) that terminate or substantially alter the protein sequence.

deCODE is delivering on the promise of the new genetics.SM Visit us on the web at www.decode.com; on our diagnostics site at www.decodediagnostics.com; for our pioneering personal genome analysis service and new focused disease scans, integrating the genetic variants included in these tests and those linked to another twenty common diseases, as well as for our new deCODEme Cardio ™ and deCODEme Cancer ™ scans, at www.decodeme.com; and on our blog at www.decodeyou.com.

These types of studies usually contain small sample sizes and focus on identifying large, rare variants in the genome rather than smaller, more common variants that may also drive disease pathology.

This section invites manuscripts describing (a) Linkage, association, substitution or positional mapping and epigenetic studies in any species; (b) Validation studies of candidate genes using genetically - engineered mutant model organisms; (c) Studies focused on epistatis and gene - environment interactions; (d) Analysis of the functional implications of genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence variation.

However, previous stem cell research on schizophrenia has focused mostly on finding those large, rare variants, similar to postmortem research.

Advances in sequencing technology enable focused explorations on the contribution of low - frequency and rare variants to human traits.

Initiated in February 1998, and covering up to 12 common diseases, the five - year collaboration is focusing on the discovery of gene variants that predispose and / or contribute to the development of these diseases, with a major emphasis on six of them.

Herein we propose a variant of Koch's postulates, aimed at providing a framework to establish causation in microbiome studies, with a particular focus on demonstrating the health - promoting role of the commensal gut microbiota.

Biases in coverage distribution, like the GC bias, are problematic, especially in analyses focusing on fragment abundance (e.g., copy number estimation, RNA - seq), but are also of importance for DNA sequencing, where variants in GC - rich and GC - poor regions might be missed due to low coverage.

Genetic counseling sessions are therefore more likely to focus on probabilities than on absolute certainties, especially when «variants of unknown significance» or «incidental findings» emerge from tests.

Pathogenic or likely pathogenic variants in genes associated with actionable disorders are Sanger verified on a separate blood sample, focusing on the ACMG secondary findings list (currently 59 genes).

Focus on the basic movements such as squats (utilize as many variants as possible!)

«No previous studies have focused on how variants in women's genes may be linked with hot flashes, and these results were highly statistically significant,» said principal investigator Dr. Carolyn Crandall, a professor of medicine in the division of general internal medicine and health services research at UCLA.

Although you should find a place for both variants in your routine, we encourage you to focus more on overloading your guns with the seated version for better mass gains.

So it would be best to do the harder, free - weight variant of the exercise early in the workout, before fatigue sets in, and save the machine version for later, when you can use it to cause maximal hypertrophy and drain your muscles of any remaining strength by focusing on solely pushing the weight.

Despite our desperate speculation on a new habanero - hot production variant of the already - spicy Focus RS, it turns out the monochromatic rendering is of a new Ford Focus RS RX rally car, specifically Ford's entry into the 2016 FIA World Rallycross Championship.

On 6 December 2006, Lexus officially confirmed the existence of a high - performance variant of the second - generation IS called the IS F. [25] The Lexus IS F sedan (USE20) premiered at the 2007 North American International Auto Show on 8 January 2007 as the launch product of Lexus» F marque lineup of performance - focused vehicleOn 6 December 2006, Lexus officially confirmed the existence of a high - performance variant of the second - generation IS called the IS F. [25] The Lexus IS F sedan (USE20) premiered at the 2007 North American International Auto Show on 8 January 2007 as the launch product of Lexus» F marque lineup of performance - focused vehicleon 8 January 2007 as the launch product of Lexus» F marque lineup of performance - focused vehicles.

The engine may be offered in both gasoline and diesel variants and focus will be on fuel economy.

For the European market, the thought of another high performance Ford Focus has become banal, but North America is eagerly awaiting the launch of the first «Euro» hot hatch variant of the Focus, with the upcoming Ford Focus ST.. The original Focus SVT was based on a European model called the Focus ST170, but the...

But for this test, we're going to focus on the diesel variant with the 6 - speed auto.

Rumors suggest that more variants could be on the way, including a softer grand touring version or an all - wheel - drive variant as a more direct rival to the Ford Focus RS, Volkswagen Golf R, and Subaru WRX STI.

Given GM's incredible focus on keeping the CT6 lightweight — Cadillac claims a curb weight neck - and - neck with the CTS despite the CT6 being the marque's current range - topping sedan in size — it's not impossible to imagine a plug - in hybrid variant getting stellar mileage in ideal conditions.

Volkswagen is ending production of its two - door GTI hot hatch, focusing instead on promotion of the four - door GTI variant.

Zevalkink said the group will focus on performance variants of existing cars, such as the 2003 Marauder edition of the Mercury Grand Marquis, within 12 to 18 months «if not faster» after deciding a variant is needed to attract or renew interest in a car line.

With a convertible model due later in the year and a performance - focused M variant likely on the horizon, the 4 - Series is the most exciting offering from Bavaria in a long time.

Body styling is not all that JMS Tuning focused on with the base kit, as it also includes a set of KW Variant 3 coilovers, which are fully adjustable.

The Golf GTE Variant impulsE show car was assembled by 14 apprentices from the Zwickau vehicle plant, the Chemnitz engine plant and the Transparent Factory in Dresden focused on e-mobility together with their mentors.

Wheel selections range from 15 - inch steel wheels on the Focus S Sedan to 17 - inch aluminum rims on Titanium and Electric variants — and the availability of an 18 - inch upgrade that also brings 235/40 performance tires and a sport - tuned suspension.

Apparently, that's the predicament the Italian automaker finds itself in with the Giulia Sportwagon variant and a report from Car Magazine reveals that the Italian automaker is dropping plans to build the wagon variant of the Giulia because it wants to focus its attention on the Stelvio SUV.

Daimler's Smart lineup has been begging for an electric variant since its inception, due to its small stature and focus on being more «green» than other cars on the road.

High - performance RS versions are no longer available, as Skoda chose to focus on mainstream variants that attract larger numbers of buyers.