If your organization is not currently using customized software for managing documents, it is probably relying on the generic
folder structure of a Windows operating system.
Splicing of the Tetrahymena ribosomal RNA precursor is mediated by
the folded structure of the RNA molecule and therefore occurs in the absence of any protein in vitro.
Their findings move the field of genetics closer to the ability to predict
the folded structure of entire genomes, which could someday help identify misfolding - related genetic diseases.
Not exact matches
«
Folding all
of our organizations into a nonprofit
structure has given us the opportunity to recreate an organization that will best support our worldwide culture
of inclusion, participation and responsibility,» wrote CEO / Engagement Officer Marian Goodell in the report.
For example, the
folding of a polypeptide chain into the three - dimensional
structure of a protein seems to follow a specific form or pattern.
Human Problem No. 1 is no longer that
of deciding whether we can escape the socio - physical in -
folding of the human race upon itself, since this is irrevocably imposed on us by the physico - chemical
structure of the Earth.
Why not assume instead that, if it is by reason
of the cosmic
structure, and not by chance, that man has become «legion», by the same token it is not through chance, but through the prolonged effect
of «cosmic coiling», that the human layer is weaving and
folding - in upon itself in the way we see it to be doing?
Repeat to make 8
fold total (this will help make the gluten
structure of the dough long and stretchy).
Don't make the mistake
of tangling that up, the wins brought people into The Process ™
fold, the build and the
structure is what they need to understand is at the core.
Typically, baby carriers — even the popular soft -
structured ones — take up quite a bit
of space in a bag and rather unwieldy to
fold.
«This pattern might be a general mechanism for functional diversification
of enzyme families, as it allows the acquisition
of new functions without disrupting the native
folding structure and primary enzyme function,» says Xiao - Ru Wang, Senior lecturer at the Department
of Ecology and Environmental Science at Umeå University.
This little bit
of stretch lets earwig wings do what a regular origami
structure can't: lock into two different conformations, open or
folded up, and transition between the two.
To function properly, proteins must
fold into a specific
structure, often with the help
of other proteins.
Paulino and his team recently designed an origami
structure capable
of being reconfigured to
fold into different shapes.
A peptide's
structure, including how its branches
of amino acids
fold into 3 - D conformations, determines which targets it can «fit» or bind to.
Despite decades
of effort, scientists still don't understand how biology achieves this protein -
folding process, or, once
folded, how protein
structures are stabilised.
And at the NASA Jet Propulsion Laboratory, researchers are demonstrating how to fabricate a larger - scale starshade's delicate petals,
fold the entire
structure up inside a rocket, and deploy and unfurl it to the size
of a baseball diamond.
As a result, the interaction between the water - loving and water - fearing residues
of the protein and the surrounding watery fluids helps drive protein
folding and stabilizes the protein's final
structure.
A single strand
of DNA can
fold onto itself to form a G - quadruplex, or guanines from multiple strands can bond to form the four - stranded
structure.
Matteo Boretto, the first author on this study, commented that «we were very excited to see that we could not only robustly grow and amplify endometrial tissue in a dish, but that the tiny
structures were also able to reproduce normal responses
of the endometrium to hormones: oestrogen makes the tissue thicken, progesterone then induces maturation including
folding (see picture), and subsequent removal
of both hormones mimics the cell shedding
of the menstrual period.»
This large - scale
fold structure is a witness
of ancient deformation associated with the rise
of the Pyrenees in the middle Eocene, 45 Million years ago.
All proteins — non-allergens and allergens alike — are made
of long ribbons
of amino acids that must
fold themselves up into intricate three - dimensional
structures to carry out their biological functions.
Most
of the proteins stabilize the
structure by interacting with several RNA domains, often using idiosyncratically
folded extensions that reach into the subunit's interior.
In ZooMS, fossil samples — typically about the size
of a breadcrumb — are processed in a way that pulls proteins out, unwinds their
folded structures and chops them up.
Moving on from basic molecular biology, the lectures cover protein
folding and DNA
structure through to the use
of databases and sequencing techniques and bioinformatics in industry.
«Proteins are made up
of a series
of amino acids that
fold into a chain in a
structure specific to that protein,» says University
of Manchester biomolecular archaeologist Terry Brown.
A riboswitch is a short piece
of RNA that can
fold into different
structures, depending on whether or not a small messenger molecule is binds to it.
Hidden in the tangled, repetitious
folds of DNA
structures called centromeres, researchers from Harvard Medical School and the Broad Institute have discovered the hiding place
of 20 million base pairs
of genetic sequence, finding a home for 10 percent
of the DNA that is thought to be missing from the standard reference map
of the human genome.
In the new study, he introduces a synthetic molecule which
folds into a helical
structure that mimics surface features
of the DNA double helix, and whose precise shape can be altered in a modular fashion by the attachment
of various substituents.
But it could play a role in helping scientists understand how proteins
fold, a process that's crucial to the most basic
structure and function
of living organisms.
Because proteins need not have exactly the same sequence
of constituent amino acids to
fold up into roughly the same shape, the researchers then had to work out the range
of sequences that would mimic the
structure of this human peptide.
Originally an Asian folk art, kirigami is the practice
of cutting intricate patterns into paper and
folding this paper, much like origami, to create beautiful, elaborate three - dimensional
structures.
Thus, these results directly demonstrate that divalent metal ions participate in general
folding of the ribozyme tertiary
structure, and further indicate a more specific involvement
of Mg (II) in catalysis.
In other spiders, this venom version
of the protein has five spiraling
folds, called helices, in its
structure.
Any such pairs code for amino acids that are likely to wind up as close neighbors in a 3D
structure — just the sort
of constraint needed to improve computer
folding algorithms.
Their capsule consists
of a star - shaped
structure with six arms that can be loaded with drugs,
folded inward, and encased in a smooth coating.
A patent is pending for the method, which is particularly suitable for measuring rough surfaces, for example those
of semiconductor
structures for electronic devices or
folded biomolecules.
Tropsha now develops models to test the relation between
structure and activity
of drug candidates and studies protein
folding and the effects
of mutations on protein
structure.
«One
of the key aspects
of these muscles is that they're programmable, in the sense that designing how the skeleton
folds defines how the whole
structure moves.
«Enzymes are spatially complex
structures which can have multiple
folds, sheets and loops,» says Prof. Dr. Olav Schiemann from the Institute for Physical and Theoretical Chemistry
of the University
of Bonn.
Proteins, the ubiquitous workhorses
of biochemistry, are huge molecules whose function depends on how they
fold into intricate
structures.
This residual
structure in the urea - unfolded protein is related to the corresponding region
of the native,
folded protein by simple rearrangements
of the residues 58 to 60.
Researchers have created the world's largest DNA origami — self - assembling
structures made up
of DNA strands
folded into a specific shape.
«The HAP2 protein from Chlamydomonas is
folded in an identical fashion to the viral proteins,» Rey said, referring to the molecular
folding that creates the three - dimensional
structure of all proteins from a simple chain
of amino acids.
Like designs made with Silly String spraying out at different velocities, the
folding of an amino acid chain into a 3D
structure is somewhat speed - dependent, and slower production could cause the protein to take an altered final form.
The research creates self -
folding structures from 3 - D printed patterns containing varying amounts
of different smart shape - memory polymers.
Scientists have determined the first 3D
structures of intact mammalian genomes from individual cells, showing how the DNA from all the chromosomes intricately
folds to fit together inside the cell nuclei.
Proteins, the components
of our body that execute, control and organize basically all functions in our cells, are made out
of strings
of amino acids, which — like an origami — are
folded into specific and complex three - dimensional
structures according to their desired functions.
However, since
folding and maintaining
of such
structures is highly sensitive to cellular or environmental stress, proteins can potentially misfold or form clumps (aggregates).
A diversity
of colorful, beautifully patterned species lives in tandem with coral reefs around the world, having adapted their appearance, body
structure and lifestyle to take refuge in the
folds of spiny, spongy, slippery reefs.