Sentences with phrase «follicular helper»

A team of chemical and biomedical engineers from the Cockrell School of Engineering at The University of Texas at Austin, in collaboration with researchers from the University of Pennsylvania, have discovered that HIV - infected patients experience a dysfunction in a certain type of immune cell: the follicular helper T (Tfh) cell.

Reversible Reprogramming of Circulating Memory T Follicular Helper Cell Function during Chronic HIV Infection.

Altered Memory Circulating T Follicular Helper - B cell Interaction in Early Acute HIV Infection.

Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T - cell - derived lymphomas

Early Rise of Blood T Follicular Helper Cell Subsets and Baseline Immunity as Predictors of Persisting Late Functional Antibody Responses to Vaccination in Humans Spensieri F., Siena E., Borgogni E., Zedda L., Cantisani R., Chiappini N., Schiavetti F., Rosa D., Castellino F., Montomoli E., Bodinham C.L., Lewis D.J., Medini D., Bertholet S., Del Giudice G. Plos ONE, 2016 11 (6): e0157066.

Cell Distance Mapping Identifies Functional T Follicular Helper Cells in Inflamed Human Renal Tissue.

One other potentially interesting finding from the Protocol C cohort is the identification of higher levels of memory T follicular helper (Tfh) cells in the blood, cells that have both transcriptional and functional properties.

She did her PhD in Immunology from Uniformed Services University, MD, studying T follicular helper cells.

mTORC1 and mTORC2 kinase signaling and glucose metabolism drive follicular helper T cell differentiation.

Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis.

Molecular analyses revealed that some of the former regulatory T cells had become follicular helper T cells (Tfh).

«Overall, the T follicular helper cells are important for B cells, you have more of those T cells in people with type 1 diabetes, they seem to be very important for the disease, and we have a new explanation of why RGS1 has been implicated,» Dr. Kissler sums up.

«In a nutshell, what we found is that this gene has an effect on the frequency of these T follicular helper cells, which are important for the B cells and seem to be important for the disease,» says Dr. Kissler, who is also an assistant professor of medicine at Harvard Medical School.

In a mouse model of type 1 diabetes, RGS1 affects the population of one type of T cell called a «T follicular helper cell» that is critical for B cells and antibody production, Dr. Kissler and his colleagues reported recently in Genes and Immunity.

«These are the T follicular helper cells.

They did discover that the inhibition changes the ways cells move within lymph nodes and the spleen, organs in which T follicular helper cells interact with B cells to promote antibody production.

According to the authors, these special immune cells are so - called insulin - specific T follicular helper cells (TFH).

When in the light zone, B cells are selected by follicular helper T (TFH) cells for migration to the dark zone.

In the study to be presented, researchers found that the T - follicular helper cell response to vaccination is greatest during the first trimester of pregnancy.

Follicular helper T cells (Tfh cells, shown in blue) play a crucial role in the maturation of antibody - producing B cells (shown in green).

The influenza specific T - follicular helper cell response varied based on trimester of pregnancy in which the vaccine was given.

The specific changes included a higher frequency of antibodies that attack one's own cells, called autoantibodies; fewer immune regulatory T cells, which were also less active in these individuals; and a higher frequency of memory T follicular helper immune cells.

«In this study, we realized that both the T follicular helper cells and memory profiles were turning on.»

Scientists already knew interleukin - 6 influenced T follicular helper cell development, and they also knew interleukin - 7 was important for memory maintenance, ensuring memory cells persist for years after an initial infection.

«We had previously discovered that in a low interleukin - 2 environment, the TFH gene program turns on, apparently pushing effector cells to become T follicular helper cells,» Oestreich said.

A group of T cells called follicular helper T cells or Tfh cells were already known to be in germinal centers and to display CXCR5.

«We've shown that a specific type of these cells, known as follicular helper T (Tfh) cells are not only necessary, but are a limiting factor that differentiates between an average and a potent antibody response to HIV,» says Crotty, a scientific collaborator with the Center for HIV / AIDS Vaccine Immunology & Immunogen Discovery (CHAVI - ID), a major research consortium led by The Scripps Research Institute.