Sentences with phrase «follow disease progression»

«The biomarkers provide new plasma or serum tests to follow disease progression in our patients.»

Not exact matches

That delay followed the failure of a trial in November of Lilly's experimental Alzheimer's treatment solanezumab, which the company had hoped would be the first medicine approved to slow progression of the disease.

Migueles has found that for those who control the virus their CD8 T cells of are both quantitatively and qualitatively different from those who follow the typical course of disease progression.

Patients were followed every eight weeks until disease progression.

The study results show that with a median (midpoint) follow - up of 20 months, 232 patients (75 percent) remained on therapy, 31 (10 percent) discontinued because of disease progression and 45 discontinued for other reasons (including 28 because of infection, eight for other adverse events and nine due to other medical events).

The vaccine slowed the progression of prion disease in the remaining 70 % of the experimental mice, allowing them to live longer than control mice, which did not receive the vaccine and died within about 200 days following infection.

In Remodeling of the Mononuclear Phagocyte Network Underlies Chronic Inflammation and Disease Progression in Heart Failure: Critical Importance of the Cardiosplenic Axis, Prabhu and colleagues showed that immune cells that are stored in the spleen were intricately involved in the heart failure that follows a heart attack, or infarction, in a mouse - model system.

The report suggests that patients may benefit from additional assurances from clinical staff regarding; success rates in halting disease progression with anti-VEGF therapy, how it can reduce the risk of becoming blind in the future, and the low likelihood of serious problems occurring following the injections.

Following first - line treatment, patients experiencing disease progression were randomised 1:1 to receive second - line treatment of FOLFOX plus cetuximab (Arm A; n = 74) or sole FOLFOX (Arm B; n = 79).

With this noninvasive method, researchers may be able to follow the progression of many brain disorders, including epilepsy and Alzheimer's disease, by measuring changes in synaptic density over time.

«The U.S. population is not getting any healthier, and scientists need to provide the public with easy - to - follow, evidence - based dietary recommendations to prevent the progression of obesity - related disease,» Teran - Garcia said.

Based on an analysis of existing evidence, published in an opinion article in the Nature Reviews Clinical Oncology journal on January 20, Dr. Narod argues that to achieve a cure, rather than simply delay progression or reoccurrence of the disease, women should be first treated with aggressive surgery to remove all clinically - detectable cancer cells, followed by targeted chemotherapy to the abdomen (intraperitoneal chemotherapy).

This data could then be used to follow the progression of the disease back in time to its origins (Annals of Oncology, doi.org/f9vrcx).

«This study is unique because we have taken a cohort of children at high risk of developing type 1 diabetes and then followed what changes in the microbiome tip the balance toward progression to the disease,» Xavier said.

Patients will be followed for three to five years to provide time to better understand the factors associated with disease progression and natural history.

It's very difficult to see metabolism from looking at the structure of cells, so we're trying to find ways to interrogate the function of cells or find if cells are stressed or unhappy before you actually start to see some of these hallmark structural changes of disease that ophthalmologists use to diagnose disease and follow progression.

Thus, J147 is an exciting, new compound with strong potential to be an AD therapeutic by slowing disease progression through neuroprotection as well as providing rapid cognition benefits by reversing cognition deficits following short - term treatment.

NAFLD encompasses a spectrum of disease states, from steatosis (fatty liver) to non-alcoholic steatohepatitis (also called NASH; steatosis with inflammatory changes) followed by progression to fibrosis and cirrhosis and hepatocellular carcinoma (27).

Following completion of a massive epitope discovery effort (also supported by an HHS contract), current work on MTB includes development of tools to isolate MTB - specific T cells (supported by the Gates Foundation) and identifying T cell signatures that distinguish three possible infection states: cleared infection, stable latent infection, and latent infection with high risk of progression to disease (in conjunction with a large consortium led by Henry Blumberg at Emory University).

Minimal Residual Disease (MRD) Status Following Induction Chemo - Immunotherapy Predicts Progression - Free Survival In Mantle Cell Lymphoma (MCL): CALGB 50403 (Alliance).

Progression - free survival was calculated from the date when treatment began to the date when the disease progression was recognized or the date of the last fProgression - free survival was calculated from the date when treatment began to the date when the disease progression was recognized or the date of the last fprogression was recognized or the date of the last follow - up.

At a median follow - up of 65 months, both variables independently, negatively predicted disease progression, progression - free survival (PFS) and overall survival (OS).

The good news is both diseases typically develop over the course of several decades, giving ample time to reverse the progression that leads to both diseases by following a healthy diet and supplement routine — which includes adequate levels of these important vitamins.

Also noted by IER studies are an increase in the expression levels of silent mating type information regulation 2 homolog 1 (SIRT1), an NAD + - dependent deacetylase.20 The expression of SIRT1, also increased by prolonged ER in rodents, is linked to the up - regulation of cellular stress resistance and improved outcomes in animal models of metabolic, neurodegenerative and inflammatory diseases.106, 107These findings have been suggestively accompanied by improvements in resilience to disease progression in rodent models of Type 1 diabetic nephropathy 20, survival following induced ischaemic injury 21 and a reduction in oxidative stress.105

Depending on the severity and progression of the disease, some or all of the following symptoms will be present.

The following simple screening process has been developed to help you determine whether dogs suspected to have myxomatous mitral valve disease (MMVD) have evidence of disease progression.

The only way to determine the progression of the disease is to monitor chest X-rays and perform follow - up ultrasounds as indicated.

In cases of dogs with cold agglutinin, they usually have an acute onset of the condition follow by a rapid progression of the disease.

Even when surgery follows caval syndrome rapidly, treatment often fails, and a dogs chances this late in the disease's progression are slim.

The typical age of onset in the BMD is 6.5 years, and the progression of disease is usually rapid, with a mean survival time following diagnosis of only 49 days (Abadie et al., J.Hered, 2009).

Clinical improvement of signs associated with systemic illness and pain is expected in the first week of antibiotic therapy.3 It is important that patients return for follow - up neurologic exams and radiography every 1 to 2 months to monitor for disease progression and to help direct therapy.

Depending on your pet's cardiac disease, your veterinary cardiologist may recommend follow - up echocardiograms at various time - points to monitor for progression of the disease or determine response to treatment.

When looking at dogs with multiple examinations, a total of five dogs were followed at Stage 1 for a minimum period of 0.9 years and a maximum period of 2.3 years (mean of 1.2 years) without any signs of progression to subsequent disease stages (Table 2).

A total of four dogs were followed at Stage 2 for a minimum period of 1.8 years and a maximum period of 3.9 years (mean of 2.7 years) without any signs of progression to subsequent disease stages.