Not exact matches
Even the glitteriest of gold - standard clinical
trials, for instance, are often undone by a leaden
follow -
up study that has the nerve
to arrive at a different result.
Some of Japan's largest companies, including Samsung and Deutsche Telecom, picked
up on Evernote's loyal
following and began preloading their devices with the platform, shelling out huge sums
to offer their customers pre-paid one - year Evernote
trials.
A demo or
trial request, on the other hand, is a bottom of the funnel offer and should be
followed up with a different series of emails containing content that a lead who is closer
to making a purchasing decision would be more interested in.
They can be used
to follow up on free
trials or downloads and
to offer post-customer support.
«In attending meetings, this singularity was a
trial to me, and more especially at this time, as white hats were used by some who were fond of
following the changeable modes of dress, and as some friends, who knew not from what motives I wore it, grew shy of me, I felt my way for a time shut
up in the exercise of the ministry.
Otherwise, if you'd like
to keep
up to date with the
trials and tribulations of OURC, you can
follow us on Facebook, Instagram and on the OURC website.
Ask if your child can see a new doctor for a
trial period; then,
follow up with the pediatric specialist
to discuss how things went and put both doctors in touch
to plan for the transition of care.
One randomized controlled
trial comparing home - visited families with control participants who received other community services found a statistically significant difference in mean depressive symptoms at two years post-enrollment, but this contrast was nonsignificant at three years post - enrollment.15 A second study of Early Head Start found no differences in depressive symptoms between intervention and control group participants post-intervention, although a difference was detected at a longer - term
follow -
up prior
to children's enrollment in kindergarten.10 Other randomized controlled
trial studies have not found effects of home visitation on maternal depressive symptoms.12, 16,17
The widespread assumption of safety has led researchers in fetal behaviour
to assure women volunteering for clinical
trials that ultrasound exposure of one
to one - and - a-half hours (sometimes on more than one occasion) is safe for their unborn babies - yet we know of no
follow -
up of these exposed children.
According
to flow chart no clusters discontinued the intervention or were lost
to follow -
up and there was
follow -
up of national data in all localities included in the
trial.
The intervention was not aimed at facilitating breastfeeding, rather the
trial compared women who were randomized
to early hospital discharge with telephone
follow -
up (with home visits by nurses only for those women who left hospital within 36 h of the birth «
to encourage them
to leave the hospital early») versus usual care with later discharge from hospital.
In a randomized controlled
trial with
follow -
up at ages 7.5 — 8 years (16) and ages 13 — 16 years (15), preterm infants were randomly assigned
to donated, banked breast milk or preterm formula (either as the sole diet or a supplement
to mother's milk) until they weighed 2,000 g or were discharged
to home.
JCOPE could have a
follow up case, but they would never do it while a
trial is ongoing, and we call on JCOPE
to do its job and investigate unregistered oil lobbyist Cox.»
City Court prosecutors must also direct
follow -
up investigation, conduct legal research, respond
to motions, obtain statements from witnesses, locate and secure evidence, conduct pre-
trial hearings, and take cases
to trial if they can not be resolved by a plea bargain.
The
trials lasted from 3 months
to 6 years, and the children involved were
followed up for various lengths of time after the
trials had ended.
However, prior
to this study there has been a lack of randomized controlled
trials with a long - term
follow -
up that compare the effectiveness of noninvasive treatments.
So far four people have had the internal microphone implanted and hooked
up to their normal cochlear implant, with two more
trials to follow later this year, says Jenkins, who has been assessing the devices.
We believe that photophobia is one of the elements which may increase the risk of people suffering from panic attacks, but this is a small study, so it needs
to be confirmed by a longer - term
follow -
up trial.
According
to Devinsky, 10
to 15 percent of patients with otherwise unmanageable epilepsy are potential candidates for the treatment; clinical
trials have shown that the implants reduce seizures in the treated group by an average of as much as 66 percent after three
to six years of
follow -
up.
He's also likely
to spur the FDA
to follow the course laid out by agency cancer czar Richard Pazdur in speeding new approvals, possibly setting
up a special unit aimed at orphan drugs
to hasten OKs with smaller, better designed clinical
trials.
Specifically, long term
follow up of a randomized clinical
trial that compared ADT and radiation therapy (RT)
to RT alone finds that men with significant comorbidity; most commonly prior heart attack, who received ADT died earlier, due
to a fatal heart attack, compared
to men who did not receive ADT.
The paper stresses that more research, especially randomized controlled
trials with long - term
follow -
up, would be needed
to reach a definite conclusion on the risk of TRT on cardiovascular outcomes.
Further
follow -
up of the
trial is ongoing
to determine whether chemotherapy may also be effectively spared in patients who have a mid-range Recurrence Score between 11 and 25.»
The
trial is ongoing, and Gelfand says his team will evaluate these patients at a longer
follow up to see if the effects are sustainable and if patients continue
to improve.
Larger
trials and longer
follow -
up will be needed
to confirm the results, he added.
As
follow up, Bedrosian and her team hope
to mine the randomized controlled
trial findings from the 1980s, matching those cohorts
to current NCDB patients
to see if a similar survival benefit could be observed.
On the basis of the results, insurers agreed
to pay for the drug in six more Dutch patients, and Vertex is
following up with the first clinical
trial of ivacaftor in CF patients with rare mutations.
Work done so far suggests that the technique — a modified form of IVF — is safe enough
to try in clinical
trials, the HFEA panel said, as long as several extra experiments are carried out first and children born as a result of the technique are
followed up for an extensive period.
The results of the Endovascular Therapy
Following Imaging Evaluation for the Ischemic Stroke (DEFUSE 3)
trial, presented at the International Stroke Conference 2018 in Los Angeles and published on Jan. 24 in the New England Journal of Medicine, demonstrated that physically removing brain clots
up to 16 hours after symptom onset in selected patients led
to improved outcomes compared
to standard medical therapy.
Follow up trials involving the Prymnesium Stakeholders Group a multi-agency network that includes JIC / UEA researchers the Environment Agency, angling / environmental groups and the Broad Authority are looking at how best
to apply H2O2 so that it can be most optimally dispersed in the water.
For this
trial, 1,359 patients (583 with VF and 776 without VF) with prehospital cardiac arrest and resuscitated by paramedics were assigned
to standard care with or without prehospital cooling, accomplished by infusing
up to 2 liters of 4 °C normal saline as soon as possible
following return of spontaneous circulation.
In the phase I / II clinical
trial of 20 patients, the engineered cells were deemed safe, trafficked
to the site of the tumor (bone marrow), and persisted in 90 percent of the patients who reached two years
follow up after infusion, the research team found.
The researchers performed a
follow -
up study of 168 patients from a previous randomized
trial evaluating a «practical intervention»
to help smokers quit before surgery.
The Physicians» Health Study II (PHS II) remains the only randomized, large - scale, long - term
trial to test whether a daily multivitamin reduced cardiovascular disease risk, and researchers found that after 11 years of
follow up, there was no significant difference in risk of major cardiovascular disease (CVD) events among men who took a multivitamin compared
to those that took a placebo.
The approach deserves
to be
followed up with human
trials, he adds.
Limitations of the study include losing about half of the participants
to long - term
follow -
up during the transition from a randomized clinical
trial to a cohort study.
Following patients for
up to nineteen months, tests show that eleven out of thirteen patients in the
trial now have normal or near normal levels of the previously missing factor and all thirteen patients have been able
to stop their previously regular treatment.
The authors also caution that the
follow -
up period for participants in this
trial was only six months per patient, so further research will be needed
to see if there is a long term effect and whether maintaining the training period could help
to extend the benefits of training.
They did recommend that the procedure be offered only as part of a research
trial and that families who use the technique should be required
to agree
to long - term
follow -
ups of the health of any resulting children.
Helmut Oettle, M.D., Ph.D., of the Charite - Universitatsmedizin Berlin, Germany, and colleagues conducted
follow -
up of a randomized
trial that previously reported improvement in disease - free survival with adjuvant (in addition
to surgery) gemcitabine therapy
to determine if this treatment improved overall survival.
The early findings are so promising that the researchers have been awarded a grant from the Australian Research Council, in partnership with Villa Maria Catholic Homes,
to follow up on the study with a large randomized control
trial.
Women age 25 - 65 who have been diagnosed with HPV 16 or HPV 18 are needed
to participate in a small Phase I tolerability clinical
trial of GTL001 with only a three - month
follow -
up period.
The Lifespan Cancer Institute is Rhode Island's largest center dedicated
to the diagnosis and treatment of all cancers and blood disorders;
to cutting - edge research and clinical
trials, and
to the survival and
follow -
up care of all patients.
Piller and Bronshtein's work, and the
follow -
up pieces that came out of this investigation, applied real pressure on the government
to fortify its efforts
to improve clinical
trial data reporting.
This includes the adaptation of the protocol
to national requirements, preparation and adaptation of the patient information sheet and informed consent form, preparation of the documentation required for submission
to Ethics Committees and Competent Authorities, submission of the clinical
trial Application dossier (CTA) and regulatory
follow -
up.
The long - term
follow -
up results of the ZUMA - 1
trial show that axi - cel remissions can last for years, and these are patients who did not respond
to chemotherapy.»
Cardiovascular risk factors after antenatal exposure
to betamethasone: 30 - year
follow -
up of a randomised controlled
trial
A streamlined behavioral therapy delivered in a pediatrics practice offered much greater benefit
to youth with anxiety and depression than a more standard referral
to mental health care with
follow -
up in a clinical
trial comparing the two approaches.
This successful strategy has now progressed
to the next level, and a study in STEM CELLS provides a comprehensive description of the first - in - man
trial in 35 patients and an 18 - month
follow -
up [3].
The panel discussed progress that's been made including the
follow -
up to the RV144 Thai prime - boost
trial results and in the development of the next generation of vaccine candidates for testing.