Sentences with phrase «following hematopoietic stem»

Not exact matches

«Proper blood cell production is dependent on functioning hematopoietic stem and progenitor cells that are destroyed during conditioning procedures for transplantation or following bone marrow injury,» said the study's first author Kevin A. Goncalves, who performed this research as part of his PhD studies in cellular and molecular physiology at the Sackler School.

The blood ancestors are usually called hematopoietic stem cells; these cells were classically defined as a specific category of multipotent cells at the top of the hierarchy that can differentiate into any blood cell type by following a deterministic program.

Journal reference: JAMA, C - Peptide Levels and Insulin Independence Following Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in Newly Diagnosed Type 1 Diabetes Mellitus

She then followed up with a closer look at role of the Igf2 signaling pathway in coaxing quiescent hematopoietic stem cells to start dividing and maturing into multi-lineage progenitors that ultimately give rise to specialized blood cells.

Following introduction into human CD4 + T cells [23] or hematopoietic stem cells [28] via an adenovirus vector or DNA nucleofection, respectively, the ccr5 gene was efficiently and specifically disrupted.

As a result, they are currently being investigated as a cellular therapeutic for the treatment of autoimmune diseases and long - term patient and graft survival following solid organ transplantation, and allogeneic hematopoietic stem cell transplantation.

Patients who receive HSCT receive high doses of chemotherapy, with or without radiation, followed by infusion of hematopoietic stem cells (HSCs)-- rare cells that reside within the bone marrow and are capable of producing all varieties of blood cells.

Following the irradiation, the researchers transplanted each monkey's own virus - free hematopoietic stem cells.

We further describe a mesenchymal sub-population with stem cell - like characteristics that gives rise to both lineages and, at the same time, acts as a principal component of the hematopoietic niche by promoting competitive repopulation following lethal irradiation.