Intraperitoneal injection of the HIF - 1α inhibitor, YC1,
following tumor initiation reduces the hypoxic CSC effect in MCF7 xenografts and results in no correlation between xenograft size and MFC (Fig. 5C).
We have found that the
initiation of pancreatic cancer does not
follow the classic paradigm seen in colon cancer where loss of a
tumor suppressor gene initiates tumorigenesis and then acquisition of an oncogene promotes
tumor formation.