Sentences with word «fop»

The word "fop" refers to a man who is overly concerned with his appearance and fashion, often seen as vain or foolish. Full definition
Most notably, the studies are based on transient transfection of wild - type and mutant gene constructs into cultured cells or into zebrafish embryos and are unlikely to reproduce the specific mutant gene dose that is present in heterozygous mutant cells in FOP patients.
«The implications for targeted clinical trials and for compassionate clinical use of HIF - 1α inhibitors in the treatment of FOP flare - ups are promising, however we need more data on dosing, duration, timing, rebound, resistance and long - term safety,» Pignolo said.
Our concern was that treating children with FOP with palovarotene would synergize to further impact their overall growth, potentially leading to additional health complications.
March 9: Historical Fiction panel & signing for FOP in Lake Forest, IL (along with Marci Jefferson, Jessica Brockmole, and Evangeline Holland)
For example, FOP research began almost 30 years ago at Penn..
Unlike the skin cells from which they originated, the human iPS cells created from FOP patients show increased cartilage formation and increased bone mineralization, two critical steps that are necessary to form mature bone.
The Stupid Dreamer, otherwise known as Fop Wordmangler, isn't really a «dark scourge» as he is a blithering nincompoop.
The extra bone that appears in FOP flare - ups progresses through a cartilage stage before replacement with mature bone cells, following a sequence of bone formation seen during normal skeletal development.
Induced pluripotent stem (iPS) cells offer an attractive model to study the disease, because researchers can take cells from the patient that are unaffected by FOP and then reprogram the cells into soft tissue cells for study.
To find out, he and his colleagues gave FOP mice a drug that blocked that ligand - receptor interaction.
March 2: Historical Fiction panel & signing for FOP at RJ Julia, Madison, CT (along with Beatriz Williams, Lauren Willig, Marci Jefferson, Jennifer Robson, Jessica Brockmole)
A tantalizing lead came from studying FOP lesions themselves.
The current JBMR study extended that research by using palovarotene in a mouse model carrying the same human gene mutation that causes FOP.
The findings support the hypothesis that FOP lesions thrive in a hypoxic microenvironment, not simply due to oxygen deprivation, but also because of a maladaptive response to hypoxia by the HIF - 1α molecular alarm, similar to that seen in cancer.
And FOP plays a lot of those songs that people forgot they loved.
Researchers at the Center for iPS Cell Research and Application (CiRA), Kyoto University, took advantage of this strategy by reprogramming FOP patient cells and then seeking candidate molecules that could explain how the disease initiates.
If these results translate to humans, we may be able to treat children with FOP early in life, before the disease progresses.»
When she discovered FOP and the work of Frederick Kaplan, a professor of orthopedic surgery at Penn, she realized she had found a puzzle that was «a disease of misregulated cell differentiation,» she says.
Most importantly, when the team disabled the HIF - 1α cellular alarm, BMP signaling in human FOP bone progenitor cells was restored to levels comparable to cells in normal oxygen.
Economides first learned about FOP back in 1996, just after finishing a postdoctoral fellowship at Regeneron, then a young biotech company focused on neurological disorders.
I made a joke that I had had a hard time getting my shoes tied that morning and without missing a beat he turned to me and said, «girl, you just got ta wear flip fops
N64 owners balked at this inconvenience like spoiled seventeenth century fop using a lace handkerchief to wave away unsatisfactory hors d'oeuvre.
For the purpose of FOP drug discovery, scientists have normally focused on molecules associated with BMP signaling.
In 2006, researchers discovered the genetic defect behind FOP: A mutated version of the gene ACVR1, which in patients produces an overactive form of a cell surface protein called a transmembrane receptor.
«The guys are completely characterless fops, it's ridiculous.»
Will American Jews be best served by this delusional fop?
The NPM system may be a good option as the basis for establishing FOP labelling criteria, although more comparisons with other systems are needed.
The windswept, bumbling fop that is Boris Johnson (who somehow currently presides as the Mayor of London) has seen fit to approve Tottenham's plans to redevelop White Hart Lane into a 56,000 capacity stadium by turning the current North Stand around and building out into the vacant car - park situated directly behind it.
Even the First Lady finds this flip - fop perplexing, reportedly saying at a recent gathering of school nutrition leaders, «Help me understand why, especially given the fact that the School Nutrition Association worked to pass the original changes in the nutrition standards.
Iain Glen is the erstwhile estate jester, Kuzovkin, a fallen gentleman and linen cupboard resident, who is incessantly humiliated by grandiloquent fop Tropatchov (a darkly camp Richard McCabe).
Working closely with Kaplan, Shore and her postdoctoral fellows and graduate students attend patient examinations, host lab tours for families, and generally stay connected to the small, close - knit FOP community.
«These different stages represent potential targets for limiting or stopping the progression of the disease, and may also be useful for blocking abnormal bone formation in other conditions besides FOP.
FOP results from a gene mutation that causes a defect in the receptor protein to which BMPs bind, thereby increasing bone formation.
These results mean that the drug is likely safe to use in children with FOP without concerns about affecting normal skeletal bone growth.
This complicates study of FOP because the trauma associated with acquiring patient cells could stimulate the irregular bone growth.
«Because patients normally show FOP symptoms after trauma or inflammation, we thought this would be a good strategy,» Ikeya said.
That international study is being done at four sites, including Penn Medicine, and is testing whether palovarotene is safe and effective in children and adults experiencing FOP flare - ups.
The drug had a potent effect — it prevented FOP extra-skeletal bone formation and also preserved limb motion and normal bone growth in young mice.
One question was whether the mutated ACVR1 receptor in FOP needed the ligand to trigger excess bone growth, or whether the receptor's modest, perpetual activity could trigger new bone on its own.
The few thousand or so people with FOP worldwide live with grueling uncertainty: Some of their muscles or other soft tissues periodically, and abruptly, transform into new bone that permanently immobilizes parts of their bodies.
Twenty years after he first stumbled on FOP, Economides and his colleagues report today that the gene mutation shared by 97 % of people with the disease can trigger its symptoms in a manner different than had been assumed — through a single molecule not previously eyed as a suspect.
Patients with FOP carry the ACVR1 mutation in every cell, while the gene is mutated only in the tumor cells of DIPG patients.
«That makes FOP an ultra-rare genetic disease and POH ultra-ultra rare,» he said.
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