Sentences with phrase «for abl»
Home fix and flip loans are the key to profitability and leverage in this scenario, and these real estate investor loans have always been a primary focus for ABL.
https://www.abl1.net/
About Blog AsiaBridge Law (ABL) maintains a network of professional, affordable and fully licensed lawyers across Asia who provide legal support for ABL clients.
Steven specialises in asset based lending acting for ABL providers on a pan European basis.
About Blog AsiaBridge Law (ABL) maintains a network of professional, affordable and fully licensed lawyers across Asia who provide legal support for ABL clients.
SAN FRANCISCO, July 18, 2017 — Following the National Principals Conference in Philadelphia, education technology startup Abl announced the release of its Fall 2017 cohort application for Abl Master Scheduler, a cloud - based software platform designed to simplify the school scheduling process.
About Blog AsiaBridge Law (ABL) maintains a network of professional, affordable and fully licensed lawyers across Asia who provide legal support for ABL clients.
Here, we uncovered a role for the ABL kinases in promoting breast cancer bone metastasis through the regulation of distinct pathways required for tumor colonization and survival in the bone microenvironment.
These findings reveal a function for ABL kinases in the regulation of breast cancer bone metastasis and tumor - induced osteolysis in vivo.
The allosteric inhibitors specific for ABL kinases (which are currently in clinical trials) provide a potentially useful tool for selectively targeting ABL kinases in metastatic breast cancer types with an increase in the ABL pathway signature (58).
Further, we identified a role for ABL kinases in promoting the expression of multiple pro — bone metastasis genes such as AXL (which encodes a receptor tyrosine kinase), IL6 (which encodes interleukin - 6), MMP1 (which encodes matrix metalloproteinase 1), and TNC (which encodes tenascin - C) through TAZ - and signal transducer and activator of transcription 5 (STAT5)-- mediated signaling.
Regardless, our data support a role for ABL kinases in the regulation of TAZ protein abundance and activity in breast cancer cells.
Here, we uncovered a critical role for ABL kinases in the regulation of breast cancer metastasis to bone.
Not exact matches
For companies with a strong credit rating and advanced, verifiable financial reporting (such as receivable and payable summaries), Liquid Capital's Asset - Based Lending (ABL) solution provides an excellent financing option that is more cost - effective, creative and discreet than anything else in the marketplace.
The first out ABL lenders sought full payment for contingent indemnification claims and certain expenses as a condition to a credit bid by Standard General, its counterparty under the 2013 credit agreement AAL.
Kastner, who has extensive ABL and corporate finance experience, was a logical choice for Bibby.
Regular ABF Journal contributor Lisa A. Miller spoke with five ABL leaders to get the pulse of the ABL outlook for 2015.
Its regional brands — such as ABL Management, Aladdin, A'viands, Cura, STARR Catering and Valley Services — have operational autonomy in their local regions and markets and receive overall corporate support for finance, purchasing, sales and marketing and human resources.
Chicago, IL, April 3, 2018 — Coveris Holdings S.A. («Coveris» or «the Company»), a premier global packaging manufacturer, today announced an amendment process to its existing credit agreement dated November 8, 2013 to allow for the full repayment of the Senior Notes, the USD Term Loan and the ABL Facilities.
IT SHOULD be the moment of truth for the Airborne Laser (ABL).
Developed by the US Department of Defense's Missile Defense Agency (MDA), the ABL aims to focus a beam of laser energy in the megawatt range for several seconds onto a missile at a...
Although the Airborne Laser (ABL) was fired from a stationary plane at a target on the ground just a few metres away, the test marked a milestone for the weapon, developed by aerospace firms Boeing, Lockheed Martin and Northrop Grumman.
The resulting thermoplastic — called ABL for acrylonitrile, butadiene, lignin — is recyclable, as it can be melted three times and still perform well.
The activity of tyrosine kinases is typically regulated in an auto - inhibitory fashion, but the BCR - Abl fusion gene codes for a protein that is «always on» or continuously activated leading to unregulated cell division (i.e. cancer).
This gene encodes for a Bcr - abl fusion protein.
However, whether ABL kinases have a role in the regulation of cellular processes critical for metastasis, other than invasion, has not yet been evaluated.
To evaluate whether loss of ABL kinases affected TAZ activity, we performed chromatin immunoprecipitation (ChIP) analysis using primers for TAZ targets identified by ChIP sequencing analysis (42).
Abl kinases are required for vascular function, Tie2 expression, and angiopoietin - 1 — mediated survival
We found that ~ 90 % knockdown of ABL1 alone resulted in enhanced ABL2 expression and did not produce a significant decrease in the phosphorylation of CrkL, a reporter for the activation state of the ABL kinases (Fig. 2K), and did not inhibit metastasis (Fig. 2, L and M).
Our data raise the possibility that inhibition of ABL kinases can increase apoptosis of breast cancer cells and block osteoclast activation, which is required for osteolytic metastasis.
These results demonstrate that ABL kinase activity is required for osteolytic metastasis in breast cancer and suggest that pharmacological inhibition of the ABL kinases may be an effective treatment for bone metastasis.
To identify key molecular mediators of the ABL kinases implicated in the regulation of the ABL1 / ABL2 - dependent pathways, we analyzed the expression of individual genes for transcripts altered by loss of the ABL kinases.
Mechanistically, we found that STAT5 was required for the production of the secreted factors MMP1, IL - 6, and TNC, downstream of ABL kinases.
Together, these data revealed a functional link between the ABL kinases and TAZ signaling leading to increased AXL abundance in breast cancer cells, and identified a potentially druggable pathway for the treatment of breast cancer bone metastasis.
IC50 for c - ABL for both inhibitors is > 100 μM.
This rules out the possibility that resistance to inhibitors results from a steric hindrance as proposed for the Thr315 mutations of ABL.13, 33 However, the crystal structures of JAK1 and JAK2 also show that Phe958 or Tyr931, respectively, are in direct contact with the CMP6 inhibitor.21 The replacement of Phe958 by Val / Cys / Ser / Leu abolishes this interaction and should decrease the affinity for this compound (Figure 2C).
In addition to RIPK2 binding as part of this computer - based (initial) screening, we selected compounds that inhibited epidermal growth factor receptor (IC50 values > 1000 nM; weak inhibitory activity) along with weak binding interactions in the EGFR and c - ABL binding sites, two common off - targets for previously identified RIPK2 inhibitors.
Initial empirical testing for c - ABL was carried out via an in vitro kinase approach with purified recombinant kinases at the MRC Protein Phosphorylation and Ubiquitination Unit in Dundee, Scotland.
This work, and that of colleagues Brian Druker and Novartis, led to the development of the kinase inhibitor imatinib (Gleevec) as primary therapy for chronic myelogenous leukemia (CML), and the discovery that imatinib resistance is caused by BCR - ABL kinase domain mutations.
When I looked up «GMO soy rats» originally, at least 5 years ago, the researchers admitted to not being abl; e to find any sources that were 100 % GMO free so they did the best they could, they used the least GMO modified soy they could get for the control.
ABL Photography also provides event photography service for parties, anniversaries and charity events.
About Blog ABL Photography is a portrait photography studio, specialised in studio portrature for families, children, maternity, new borns as well as business portraits.
Developed in collaboration with secondary school leaders from Massachusetts, California, Pennsylvania, Tennessee, Rhode Island, and Texas, Abl's dynamic school scheduling platform makes it easier for principals to design and manage the daily life of a school, eliminating the need for spreadsheets, magnet boards, and stacks of paper.
«School leaders have been asking for tools like this for decades,» said Lee Fleming, principal of San Diego's Bonsall High School, an Abl design partner.
Following design partnerships with school leaders in 6 states, Abl will expand access to master scheduling software for up to 150 secondary schools this fall.
«The master schedule is, in many ways, the blueprint of a school — but a Rubik's Cube of programs, people, and events can make the scheduling process overwhelming and time - consuming for school leaders,» said Abl Founder and CEO Adam Pisoni, who previously served as CTO and Co-Founder of Yammer.
Both Gus and Aaron are key parts of our sales team and we are very pleased to hear that they were abl... e to take a negative experience and turn it into a very memorable car buying experience for you!
About Blog ABL Photography is a portrait photography studio, specialised in studio portrature for families, children, maternity, new borns as well as business portraits.
If your useless comments should be directed at anyone it should be at Microsoft's incompetent staff for not being abl to do their jobs correctly, and not «Sony fans».
Free market economics (and capitalism) appropriately restrained to activity that is abl to be shown (being shown is different from being able to be deceptively marketed) to be advancing global humanity to a lasting better future for all is almost certain to be the only viable future for Free Market economics.
When faced with an alcohol or liquor license issue in South Carolina, it is important that you contact an experienced ABL attorney at Strom Law to guide you through the application process, may help ensure that your request for a South Carolina alcohol or liquor permit is approved.