Sentences with phrase «for ankyrin»
Not exact matches
Like ankyrins, tankyrase contains 24 ankyrin repeats in a domain responsible for its interaction with TRF1.
http://science.sciencemag.org/
Their collaborators — Paul Jenkins, Ph.D., and Vann Bennett, M.D., Ph.D., then at Duke University Medical Center — had tried creating a mouse mutant completely lacking the ankyrin - G protein, but the mice didn't survive because ankyrin - G seems to be required for nervous system development.
In baseline tests, the high - energy ankyrin - G mice usually swam longer, only floating for about 10 seconds of the 200 second test compared to the normal mice that floated about 50 seconds, but after several sessions with the bully mice, the ankyrin - G mice were quick to give up and float, remaining still for well over 100 seconds on average.
The research group hopes to use its ankyrin - G mice to better understand the biology of bipolar disorder, to help clarify how lithium works to treat bipolar disorder, and to test new treatments for bipolar disorder.
To see if the mutant mice developed depressive - like traits under those conditions, the researchers stressed the ankyrin - G mice by placing them with a bigger, «bully» mouse for daily sessions over two weeks.
Specifically, the mice lacked the protein ankyrin - G, in particular neurons in the brain, a defect that appears to make the animals both hyperactive and less fearful, a behavioral profile suggestive of a mania - like state for a mouse.
To see what was happening in the brains of these ankyrin - G mutant mice, the researchers analyzed the cell components in inhibitory synapses connecting with pyramidal neurons, finding that two proteins known as GAT1 and GAD67 — responsible for making the neurochemical GABA that dials back nerve impulses — were at much lower levels in the synapses on pyramidal neurons in ankyrin - G mutant mice than in normal mice.
There are also many other differences in the number or coding sequences of ankyrin repeat genes between wMel strain genomes and wAu [21], [49](see also [15] and [48] for sequence of wMelCS).