Sentences with phrase «for cell reprogramming»

For cell reprogramming, there are about 2,000 known transcription factors that might be useful in changing a cell from one state to another, such as creating induced pluripotent stem (iPS) cells from skin cells.

Adult stem cell research does take place at Georgetown, in the Department of Biochemistry and Molecular & Cellular Biology, in addition to groundbreaking stem - like cell research in the Center for Cell Reprogramming.

By matching normal and cancer cells from a patient, we can now study the differences — what molecules are key to tumor development and growth, and, ultimately, match treatments that might disable this cancer,» says the study's senior investigator, associate professor of pathology, Xuefeng Liu, MD, a member of the Center for Cell Reprogramming (CCR) at Georgetown University Medical Center.

«Big step for cell reprogramming.»

Not exact matches

Bellicum is among the flurry of biotechs investing heavily into cell therapies such as experimental chimeric antigen receptor T - cell (CAR - T) treatments for cancer (this is the next - gen treatment that involves reprogramming immune cells to become cancer killers and has shown promise in blood cancers, which Bellicum specializes in).

In 2005, before a Congressional hearing in the U.S., Prof. George Q. Daley of Harvard spoke forcefully and influentially about the necessity for embryonic stem - cell research to go ahead, and dismissed suggestions that one could work instead with «induced pluripotent stem cells» («iPS», i.e. stem cells reprogrammed from some cells of a living adult).

He has more than fifteen years» experience in the life science industry, including the product development, market development and commercialization of cells, scaffolds, cell reprogramming tools and cell culture media for regenerative medicine and bioprocessing applications.

Next they tested thousands of different compounds for their ability to kill these reprogrammed cells.

For the first time, specialised cells have been reprogrammed into the equivalent of embryonic stem cells without using genes that might trigger cancer.

Ding's team took cells called fibroblasts from the connective tissues of mouse fetuses and bathed them in a cocktail of the four polyarginine - tagged proteins for 12 hours, then they removed the reprogramming proteins for 36 hours, and repeated this cycle four times over.

This microscope picture shows a colony of induced pluripotent stem cells (iPSC) obtained by reprogramming a specialized cell for two weeks.

«This research has broad impact, because by deepening our understanding of cell reprogramming we have the potential to improve disease modeling and the generation of better sources of patient - specific specialized cells suitable for replacement therapy,» said Plath.

Scientists have rolled back time for live mice through systemic cellular reprogramming, according to a study published December 15 in Cell.

Testing each of these factors for their ability to return differentiated tumor cells to a stem - like state, identified a combination of four — POU3F2, SOX2, SALL2 and OLIG2 — that was able to reprogram differentiated tumor cells back into glioblastoma stem cells, both in vitro and in an animal model.

This year those breakthroughs include tools for reprogramming living cells and rendering lab animals transparent; ways of powering electronics with sound waves and saliva; smartphone screens that correct for the flaws in your vision; Lego - like atomic structures that could produce major advances in superconductivity research; and others.

• Scrutiny continued this week for Haruko Obokata, the Japanese stem - cell scientist whose apparent stunning advance — reprogramming adult stem cells by stressing them in acid — has proved difficult to reproduce, even by her own collaborators.

In addition to helping understand disease by providing more powerful study models, «what this technology would allow you to do is reprogram a skin cell, for example, from a Parkinson's patient... into a pluripotent cell and then in a petri dish redirect that cell into... a neuron» to treat that patient.

Others in that camp suggest that reprogrammed adult cells, (induced pluripotent, or iPSCs) can effectively replace the need for pluripotent embryonic stem cells.

«Reprogramming patients» cells offers powerful new tool for studying, treating blood diseases.»

But to convert adult cells into embryonic - like cells means genetic reprogramming, for example with a virus, and the reprogrammed cells do not yet match embryonic stem cells.

«This was strange because it meant that, contrary to what we believed, MYC isn't necessary for cells to reprogram efficiently,» said Tim Rand, MD, PhD, staff scientist at Gladstone and a first author of the study.

The Third International Congress on Responsible Stem Cell Research, scheduled for 25 - 28 April, was to focus on clinical applications of adult and reprogrammed stem cells.

Scientists at the Gladstone Institutes revealed, for the first time, a method to reprogram specific T cells.

«How to reprogram cells in our immune system: The discovery could improve treatments for autoimmune diseases and cancer.»

«By identifying the areas of the genome that are directly involved in the reprogramming, we have also identified an important factor in the process — the gene regulatory protein KLF11 (Kruppel Like Factor - 11), which is found in all fat cells, and we have shown that it is required for the reprogramming to take place.»

Moriguchi also presented a July 2011 patent application for «Methods and Compositions for Reprogramming Cells,» that names himself and Chung as the inventors and designates the assignee as «The General Hospital Corporation, Boston, MA,» the MGH legal entity.

Researchers at the Center for iPS Cell Research and Application (CiRA), Kyoto University, took advantage of this strategy by reprogramming FOP patient cells and then seeking candidate molecules that could explain how the disease initiates.

«By reprogramming human cells, scientists have created new opportunities to study diseases and develop methods for diagnosis and therapy,» the Nobel judges wrote.

Perhaps in the future it may be possible for doctors to apply flexible bandages to severely burnt skin to reprogram the cells to heal that injury with functional tissue instead of forming a scar.

The approach — reprogramming somatic cells — promises to be a boon for regenerative medicine.

Since Yamanaka's breakthrough, dozens of groups have reported other ways of reprogramming cells as well as techniques to control differentiation of stem cells into neurons, cardiovascular cells, and other tissues of interest for regenerative medicine.

Researchers might generate personalized brain organoids from the reprogrammed skin cells of individuals with, say, schizophrenia and test which medications work best for patients with particular genetic profiles of the illness.

Summers and the research team, led by Dr. Mike Jensen at the Ben Towne Center for Childhood Cancer Research at Seattle Children's Research Institute, are opening PLAT - 04 after discovering that of the patients who relapsed in the PLAT - 02 trial, approximately 40 percent of them relapsed with a leukemia that evolved to circumvent the CAR T cells that were reprogrammed to detect and destroy cancer.

Reprogramming of adult somatic cells into induced pluripotent stem cells (iPSCs) provides a powerful tool for in vitro disease modeling and drug screening.

The idea is that, by placing an adult cell from a diabetic, for example, into a human egg cell, the egg cell could turn back the clock of the adult DNA, or reprogram it, to its initial, pristine state.

In the nearer term, reprogrammed cells may improve the screening drug candidates for harmful side effects.

«Use of induced pluripotent stem cell (iPSC) technology» — which involves taking skin cells from patients and reprogramming them into embryonic - like stem cells capable of turning into other specific cell types relevant for studying a particular disease — «makes it possible to model dementias that affect people later in life,» says senior study author Catherine Verfaillie of KU Leuven.

These stem cells, which are similar to highly sought - after embryonic stem cells but derived from adult cells and then reprogrammed, could be turned into the cell types needed for research, including neurons and intestinal and fat cells.

In one study, geneticist Joseph Ecker at the Salk Institute in California took various stem cell lines reprogrammed from skin, fat, and other tissues and examined each line's genome for dna methylation, chemical marks that alter how genes are expressed.

The award was given for their work showing that mature cells can be reprogrammed into pluripotent stem cells.

This is all it takes for a so - called precursor fat cell to have its «epigenetic recipe» on how to correctly develop into a mature fat cell, reprogrammed.

Until that happens, though, reprogrammed cells are far from ready for the clinic.

Furthermore, the SSUP proteins are required for efficient reprogramming of induced pluripotent stem cells.

We did get some cells but they turned out to be tumour cells rather than the reprogrammed stem cells — known as induced pluripotent stem (iPS) cells — that we were hoping for.

«We believe that BPA actually reprograms the stem cells to be more sensitive to estrogen throughout life, leading to a life - long increased susceptibility for diseases including cancer,» Prins says.

The stem cell transcription factor SOX2, which is critical for stem cells, cell reprogramming, and brain development, also is activated in astrocytes in the adult brain.

This means that reprogramming process begins, there is no longer any room for chance; the genes involved are ready to be activated and enable the successful reprogramming of all the cells.

He was awarded the 2012 Nobel Prize along with Sir John Gurdon «for the discovery that mature cells can be reprogrammed to become pluripotent.»

At the same time, the work provides new clues for successfully reprogramming cells in humans and advances in regenerative medicine and its medical applications.

Researchers from the Centre for Genomic Regulation (CRG) in Barcelona have now described a novel mechanism by which adult cells can be reprogrammed into iPS cells successfully and in a very short period of time.