Sentences with phrase «for human monoclonal antibody»

«Development Trends for Human Monoclonal Antibody Therapeutics,» by Aaron L. Nelson, Eugen Dhimolea and Janice M. Reichert, Nature Reviews Drug Discovery, October 2010.

Not exact matches

Weiner, Elliott and colleagues studied the DNA sequences for two human monoclonal antibodies — one able to broadly target influenza A viruses and one able to broadly target influenza B viruses — with collaborators at Inovio and MedImmune.

«This panel of neutralizing antibodies offers the possibility of developing human monoclonal antibody - based immunotherapy, especially for health care workers,» noted the authors.

She helped lead a GSK project focused on designing a monoclonal antibody to link to the HER3 receptor on human cells as a treatment for cancer.

To avoid these problems, researchers have been trying to perfect and speed up procedures for extracting monoclonal antibodies from humans, replicating them in a lab, and then injecting them into victims suffering from the diseases they were formed to fight.

Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, called the new work a «significant advance,» noting in a statement that it «opens the way to producing [monoclonal antibodies] that potentially could be used diagnostically or therapeutically» for the flu as well as other infectious diseases such as hepatitis C and the human immunodeficiency virus (HIV), which can lead to full - blown AIDS.

This research has important implications for the use of DNA - encoded monoclonal antibody technology as a platform for delivering the next generation of immunotherapies for cancer and many human diseases.

Thus, this study has implications for analysis of human vaccine studies, as in addition to searching for defined lineages it is worthwhile to perform functional analysis of monoclonal antibodies that may have found new structural solutions to high affinity binding which can not be discerned from DNA sequence alone.

Guselkumab, a fully human monoclonal antibody targeting IL - 23, in this Phase 2 study for the treatment of PsA, was well tolerated with no unexpected safety findings in this patient population.2 Guselkumab is now being pursued in a Phase 3 development programme for psoriatic arthritis.

«The remarkable advance in technologies to isolate and manufacture human monoclonal antibodies in concentrations high enough to potentially prevent HIV is a major advance and provides the underlying principle for our enthusiasm for these trials.»

Fast - MAb addresses the urgent need for monoclonal antibodies with unprecedented specificity to native human proteins with delivery in 8 weeks.

Cells were first probed with a primary mouse monoclonal antibody against human HMOX1 (Abcam) diluted in PBS containing 1 % BSA, 0.01 % Triton X-100 for 1 hour, washed twice, and then probed with a secondary goat anti-mouse Alexa 488 antibody (Invitrogen) for 1 hour.

A fully human, well tolerated monoclonal antibody, if formulated for long duration may be a very attractive alternative to daily PrEP oral treatment for some individuals.

Some of the important and pioneering work for which Cambridge is best known and which has led to major improvements in people's lives was only possible using animals, from the development of IVF techniques through to human monoclonal antibodies.

There will be an ongoing need for a human post exposure therapeutic and so we're continuing our work with the human monoclonal antibody as a treatment that can be given to people who are exposed to Hendra virus.

Though monoclonal antibodies were a model product in his 18 years CMO experience, process development was also performed for enzymes, hormones, blood factors, immuno - modulants and vaccines with different expression systems such as hybridoma, myeloma, CHO, BHK, insect - cell / baculovirus, adherent animal and human cells.

These same challenges exist for human allergy suffers, but recently there has been a major breakthrough in the development of a new, safe and effective therapy using a monoclonal antibody that specifically binds and neutralizes human IgE that is responsible for activating inflammation - producing cells.

Key Highlight: • Facilitated the introduction of HUMIRA (adalimumab) for the healthcare professionals as the latest and the only fully human monoclonal antibody against TNF for the treatment of moderate to severe psoriasis in patient failed at least on two DMARD's.