Although elevation of lymphocytes is the most important indicator
for lymphoid leukemia, the low number of white blood cells in the initial stages makes the diagnostic process extremely difficult.
Centre
for Lymphoid Cancer maintains provincial, national and international partnerships with multi-disciplinary scientific researchers and clinicians to:
The purpose of this newsletter is to provide a brief summary of the projects underway throughout our Centre
for Lymphoid Cancer program, the people that work on them, and useful information on upcoming events.
The Centre
for Lymphoid Cancer is a multi-disciplinary research program focused on the development of new treatments and diagnostics
for lymphoid cancers.
A multi-disciplinary research program focusing on new treatments and diagnostics
for lymphoid cancers
Diagnosis of BPDCN was confirmed by the positivity of the cells for CD4 and CD56, along with other markers that are more restricted to plasmacytoid dendritic cells (such as CD123), and the negativity of the cells
for lymphoid, NK and myeloid lineage - associated antigens.
Adaptive Biotechnologies» first test,
for lymphoid cancers, also determines whether a particular treatment is effective.
Not exact matches
The assay revealed cancer subtype - specific mutational profiles that were highly similar to published mutational profiles
for all three types of
lymphoid cancer.
A new study published in The Journal of Molecular Diagnostics has established that hybrid - capture sequencing is the method of choice
for sequencing «actionable» gene mutations across the most common forms of
lymphoid cancer.
Unlike whole - genome sequencing, this assay targets a select set of genes or regions with known associations with
lymphoid cancer, allowing
for more rapid detection of a variety of mutations.
«Harnessing the power of genomic sequencing augments diagnosis and treatment of
lymphoid cancer: New assay may allow screening
for «actionable» gene mutations in routinely acquired archival biopsies, reports The Journal of Molecular Diagnostics.»
Antibody formation against sheep erythrocytes by mouse spleen cells in vitro requires interactions among antigen - treated macrophages and
lymphoid cells in cell culsters
for only a finite time.
When injected together with factor VIII into mouse models of haemophilia A, the nanoparticles deliver their payload to cells in the
lymphoid tissue that are responsible
for initiating immune responses.
«Although it's still early days
for this line of research, these findings provoke the hypothesis that MHCII + innate
lymphoid cells may be an important pathway to therapeutically target in the treatment of some chronic inflammatory diseases,» suggests Sonnenberg.
Gregory F. Sonnenberg, PhD, research associate in the Department of Medicine, Gastroenterology Division, and the Institute
for Immunology at the Perelman School of Medicine, University of Pennsylvania, with postdoctoral researcher Matthew Hepworth, PhD, report in Nature that innate
lymphoid cells (ILCs) directly limit the response by inflammatory T cells to commensal bacteria in the gut of mice.
Researchers at the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) have discovered that innate
lymphoid cells, early responders of the immune system, are primed at the DNA level
for rapid action.
Type 3 ILCs (ILC3s) are in addition essential
for the development of
lymphoid organs such as lymph nodes and
for tissue repair.
These
lymphoid cells are thus an important target
for the treatment of infection and chronic inflammation.
Through the use of powerful genomic techniques, researchers at the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) have found that the development of immune cells, called innate
lymphoid cells (ILCs), gradually prepares these cells
for rapid response to infection.
The research team, a collaborative partnership between the groups of Professor Gabrielle Belz of Melbourne's Walter and Eliza Hall Institute, and Professor Eric Vivier at the Centre d'Immunologie de Marseille - Luminy, France, found that innate
lymphoid cells (ILCs) are crucial
for protecting against bacterial infection in people with compromised immune systems.
The phenotype of NP cells generated ex vivo (Figure S8) closely resembles that of central memory CD4 + T cells found in vivo, which persist
for years in secondary
lymphoid organs and can differentiate into effector memory CD4 + T cells [45].
Tissue - cultured corneal cells were used
for in vitro studies rather than the usual
lymphoid cells since corneal cells are the relevant target cells in vivo during corneal allograft rejection.
Development and Functions of CD4 T Helper (Th) and Innate
Lymphoid Cell (ILC) Subsets Jinfang ZhuNational Institutes of Health, Bethesda, USA 10 April 201804:15 pm Host: Max Löhning, DRFZ, Berlin Location: Max Planck Institute
for Infection Biology, Seminar room 1/2 - Campus Charité Mitte
Hsiou - Chi Liou and colleagues find that c - Rel, a
lymphoid - specific member of the NF - kappaB / Rel family of transcriptional factors, is essential
for B lymphocyte survival and cell cycle progression, [i] and that it is important
for inducible cytokine and cytokine receptor expression and a key regulator of early activation and proliferation in T cells.
Canadian Society
for Immunology (CSI) Symposium Innate
Lymphoid Cells and Inflammatory Disease Monday, May 7, 3:45 PM — 5:45 PM, Room 10AB Chairs: Kelly McNagny, Univ. of British Columbia Arthur Mortha, Univ. of Toronto
[31] Recent studies show that the vaginal mucosa can support T - cell induction in the absence of MALT or secondary
lymphoid tissues, suggesting that the type II vaginal mucosa can itself act as an inductive site
for the generation of primary CD8 + T - cell immune responses.
The group of promoters, whose H3K4me3 levels were affected by combined chidamide and decitabine treatment, but not by either chidamide or decitabine treatment alone, was enriched with binding site motifs
for PU.1, a transcription factor that activates gene expression during myeloid and B - cell
lymphoid cell development15, 16 (Figure 5C).
- Chimeric Antigen Receptor - Modified T Cells
for Acute
Lymphoid Leukemia; Stephan A. Grupp MD, PhD, University of Pennsylvania Children's Hospital of Philadelphia.
Each single multiplex master mix
for TRB targets the conserved regions within the Vb and the Jb regions described in
lymphoid malignancies.
Complete phenotyping of the mouse immune system by polychromatic and mass cytometry (CYTOF), thanks to a set of standardised protocols enabling isolation of viable cells from
lymphoid and non-
lymphoid organs (lung, skin, intestine,...)
for labelling using complex ranges of antibodies whose compatibility allows the simultaneous registration of 50 quantitative parameters at least (size, structure, specific antibodies and cell viability).
STAT5 activation is required
for interleukin -9-dependent growth and transformation of
lymphoid cells
His group defined a functional niche
for B cells (around sinusoids in the bone marrow), identified the first two mutants that abrogate marginal zone B lymphocyte development, developed the concept of a follicular versus marginal zone B
lymphoid cell - fate decision, and discovered two new defined stages of peripheral B cell development, the marginal zone precursor (MZP) B cell, and the Follicular type II B cell.
Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis,
lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery
for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters
Facilitate cross-disciplinary research programs focused on understanding the biological mechanisms of
lymphoid cancers
for the development of novel therapeutic treatments
for these cancers.
Accelerate the development of novel diagnostics and therapeutics
for the treatment of
lymphoid cancers by fostering a cutting - edge multi-disciplinary research environment with a focus on clinical applications.
Lymphoid neoplasms are cancers of the immune system, which afflict both adults and children, and account
for 6 - 10 % of all neoplastic diseases.
As things make their way through your digestive system, your gut - associated
lymphoid tissue, or GALT, which is the term
for the immune system in your gut, reviews everything to check
for potentially harmful substances.
GALT stands
for gastric associated
lymphoid tissue, and MALT, mucosal associated
lymphoid tissue.
Secondary
lymphoid organs, which include the lymph nodes, tonsils and spleen, act as traps
for incoming pathogens, whereupon foreign bodies are set upon by mature lymphocytes.
Red bone marrow and the thymus gland are considered the primary
lymphoid organs and act as incubators
for maturation of lymphocytes — a type of white blood cell.
With 70 % of it housed in the Gut Associated
Lymphoid Tissue (GALT) in the intestinal wall, the ecosystem of microbial residents are responsible
for influencing the immune gatekeepers such as dendritic cells.
Adequate zinc status is essential
for T - cell division, maturation and differentiation; lymphocyte response to mitogens; programmed cell death of
lymphoid and myeloid origins; gene transcription; and biomembrane function.
LEUKOCELL 2 is a multiple viral antigen vaccine
for vaccination of healthy cats 9 weeks of age or older as an aid in preventing persistent viremia,
lymphoid tumors caused by feline leukemia virus (FeLV) and diseases associated with FeLV infection.
Proposed causes
for human IBD include defective immunoregulation of the gut - associated
lymphoid tissue that may be precipitated by permeability defects, 14 infectious and parasitic agents, 15,16 and dietary allergies.13, 17 There is provocative evidence from clinical observations and animal models to incriminate normal luminal bacteria or bacterial products in the initiation and perpetuation of canine IBD.18, 19 The clinical response to hypoallergenic or elimination diets suggest that dietary factors may influence the pathogenesis of canine IBD.8 - 11 The term «hypoallergenic» refers to a diet that is generally free of additives and preservatives, and contains a hydrolyzed protein source.
The spleen, which acts as a filter
for the blood, also contains a large amount of
lymphoid tissue.
These samples are sent off to a laboratory
for analysis, and the pathologist may be able to visualize the presence of the rickettsial organism within the
lymphoid cells.
Mediastinal: The mediastinum is a term used
for a special aggregation of
lymphoid tissue in the chest.
Steroid drugs such as prednisolone may palliate blood,
lymphoid and mast cell cancers
for a few months.
Chronic
lymphoid leukemia impairs the bone marrow and results in the under production of other blood cells that are required
for combating inflammations, allergies and infections.
Without treatment, dogs with
lymphoid tumors have a life expectancy averaging ten weeks but a few live
for six to twelve months.