In an effort to reign in the hype surrounding stem cell research that has led to a proliferation of unapproved and potentially dangerous stem cell therapies, the International Society for Stem Cell Research (ISSCR) recently released updated guidelines outlining conduct
for stem cell researchers that, for the first time, included communications activities.
The study, which lays the foundation for future preclinical work, appears June 14 in Stem Cell Reports, a publication of the International Society
for Stem Cell Researchers.
Apart from advancing our understanding of how plants regulate their growth and shape, this research presents new questions
for stem cell researchers in regards to cell size checkpoints and their importance during organism development.
Not exact matches
For example, using 3 - D bioprinters — which can print the structure of human tissue with biodegradable material — and
stem cells, which are used to populate the 3 - D printed structure,
researchers can grow actually human tissue.
The Ontario Institute
for Regenerative Medicine (OIRM) is part of a community of
researchers and organizations that are making world - leading scientific discoveries in
stem cell and regenerative medicine.
One clear positive element in the
stem -
cell debate
for me was hearing the top
researchers in biomedical science reinforce The Catechism of the Catholic Church (CCC 343: «Man is the summit of the Creator's work, as the inspired account expresses by clearly distinguishing the creation of man from that of other creatures»).
The National Institutes of Health (NIH) has allowed a contract
for the dissemination of embryonic
stem cell lines approved
for US government funding to lapse, shuttering a key
stem cell bank, and doubling the price
researchers pay
for samples of some human embryonic
stem cell (hESC) line... from $ 500 per vial of frozen
cells to $ 1,000.
He decreed that the case brought by
researchers Drs James Sherley and Theresa Deisher, along with a number of Christian groups including the Christian Medical Association, should be heard; and ordered an injunction temporarily blocking federal funding allocated
for human - embryonic -
stem -
cell research.
Fetal
stem cells, which may turn out to be useful
for treating conditions like Parkinson's, need to be cloned — that is,
researchers need to take a
cell from a body, put it in an embryo, and grow that embryo to a certain small size before harvesting the
stem cells.
The
researchers detected this SMN long noncoding RNA, or lnc - RNA (pronounced «link RNA»)
for short, in human embryonic kidney
cells, brain
cell samples and neurons derived from the
stem cells of healthy people and those with spinal muscular atrophy type I and II.
In 2014,
for example, according to data in the article,
stem cell researchers between 35 and 39 were successful more often than any other age group, winning grants 21.6 % of the time, as compared to success rates ranging from 18.3 %
for those between 40 and 44 to 13.4 %
for those in the 55 to 59 age group.
The soon - to - be-built Centre
for Stem Cell Research is an attempt to draw together in one place the cream of stem cell researchers in Can
Stem Cell Research is an attempt to draw together in one place the cream of stem cell researchers in Can
Cell Research is an attempt to draw together in one place the cream of
stem cell researchers in Can
stem cell researchers in Can
cell researchers in Canada.
Researchers at Geron, meanwhile, had successfully derived neurons from human embryonic
stem cells and were pursuing research that would eventually look to repair the damage caused by spinal - cord injuries, a possible use
for embryonic
stem cells that was much touted at the time.
A team of
researchers at the Stanford University School of Medicine has used a gene - editing tool known as CRISPR to repair the gene that causes sickle
cell disease in human
stem cells, which they say is a key step toward developing a gene therapy
for the disorder.
Researchers at the Université libre de Bruxelles, ULB define
for the first time the changes in the
stem cell dynamics that contribute to wound healing.
Base oxidation regulates gene activity In cooperation with colleagues at LMU, as well as
researchers based in Berlin, Basel and Utrecht, Carell and his group have now shown,
for the first time, that a standard base other than cytosine is also modified in embryonic
stem cells of mice.
According to Izpisúa Belmonte, who is also a professor at the gene expression laboratories of the Salk Institute
for Biological Studies in San Diego, California, CMRB aims to become «a research centre of excellence in south Europe in the line of world - recognized institutions such as the Salk or the Whitehead institutes, where both pre - and postdoctoral
researchers receive multidisciplinary training of the highest quality» in
stem cell biology and
cell regeneration.
Targeting exhausted immune
cells may change the prognosis
for patients with acute myeloid leukemia (AML) relapse after a
stem cell transplant, according to Penn State College of Medicine
researchers.
In science news around the world, scientists march in India to call
for more research funding, a South Korean
researcher who was enmeshed in a
stem cell scandal a decade ago resigns from a newly created government position, Canada establishes a vast marine conservation area in the High Arctic, a highly regarded advocate
for science is convicted of financial misdemeanors in Egypt, and more.
Also,
researchers could carefully select which blood types to culture with each batch of
stem cells, creating stockpiles of needed blood products
for people with extremely rare blood types whose blood
cell makeup makes it challenging to find good blood matches
for transfusions because they would reject most other types of blood.
Researchers at the University of Louisville have discovered a mechanism involved in skeletal muscle repair that may enable clinicians to boost the effectiveness of adult
stem cell therapies
for diseases such as muscular dystrophy.
Researchers, led by Joshua Mayourian at the Icahn School of Medicine at Mount Sinai, used mathematical modeling to simulate electrical interactions between these
stem cells and heart
cells to develop insight into possible adverse effects, as well as to hypothesize new methods
for reducing some potential risks of this therapy.
Realistic
stem cell therapies to replace diseased or damaged tissue may still be years away, but
researchers have uncovered a promising new use
for these undifferentiated
cells: they can be programmed to become patient - specific laboratory models of inherited liver disease.
Studying mice with injuries to the lining of the stomach, the
researchers blocked the animals» ability to call on
stem cells for help in the stomach.
Although British
researchers had discovered embryonic
stem cells in laboratory animals in 1981, it wasn't until 1998 that a Wisconsin team announced it had isolated
stem cells from human embryos
for the first time.
Collins and others argue not just
for a permanent removal of the injunction to resume research with confidence, but also
for an extension of the number of embryonic
stem cell lines available to federally funded
researchers.
Brazilian
researchers from the D'Or Institute
for Research and Education (IDOR) and Federal University of Rio de Janeiro (UFRJ) have demonstrated the harmful effects of ZIKA virus (ZIKV) in human neural
stem cells, neurospheres and brain organoids.
Researchers are designing the first clinical trials of
stem cell treatments
for fetuses afflicted with rare bone and blood diseases.
In a study recently published in the journal Nature Biotechnology, HSCI
researchers at Harvard University and Massachusetts General Hospital (MGH), in collaboration with Boston Children's Hospital and Dana Farber Cancer Institute, have developed a non-toxic transplantation procedure using antibodies to specifically target blood
stem cells in mice, an approach they hope will make blood
stem cell transplants
for these patients far less toxic.
UTSW co-authors include: Co-lead author Maria Winter, a research associate; Dr. Luisella Spiga, a postdoctoral
researcher; visiting fellow Lisa Büttner; graduate students Elizabeth Hughes and Caroline Gillis, all of Microbiology; Dr. Breck Duerkop, Instructor, Immunology; Cassie Behrendt, a research technician, Immunology; Dr. Lora Hooper, Professor and Chair of Immunology with appointments in Microbiology and in the Center
for the Genetics of Host Defense, a HHMI Investigator and holder of the Jonathan W. Uhr, M.D. Distinguished Chair in Immunology, and the Nancy Cain and Jeffrey A. Marcus Scholar in Medical Research, in Honor of Dr. Bill S. Vowell; Dr. Luis Sifuentes - Dominguez, Instructor of Pediatrics; Dr. Kayci Huff - Hardy, clinical fellow, Internal Medicine in the Division of Digestive and Liver Diseases; Dr. Andrew Koh, Associate Professor of Pediatrics and Microbiology and in the Harold C. Simmons Comprehensive Cancer Center as well as Director of Pediatric Hematopoietic
Stem Cell Transplantation at Children's Health; and Dr. Ezra Burstein, Professor of Internal Medicine and Molecular Biology and Chief of the Division of Digestive and Liver Diseases.
For instance, medical
researchers might succeed in creating complex tissues and organs derived from patients» own
stem cells.
The therapeutic use of
stem cells is a promising area of medicine
for the decades ahead and
researchers are examining why
stem cells function in certain types of niches, microenvironments, and pockets of activity.
At that time, the plaintiffs — adult
stem cell researchers James Sherley and Theresa Deisher — expect to file what's called a motion
for summary judgment, which asks that the case be decided without a trial.
For example, by taking neural
stem cells from a patient with schizophrenia,
researchers might turn back the clock and track the onset of the condition in an organoid.
By tinkering with the medium in which
cells are grown,
researchers at the Salk Institute
for Biological Studies created a type of
stem cell with a survival rate of 30 to 40 percent, vs. 1 percent.
«We can work with any embryonic
stem cell line from any source and are not restricted to working with the very small number of federally approved lines as is the case
for researchers in the United States,» says Minger.
More recently,
researchers have induced
stem cells from diseased human somatic
cells, which may serve as new model systems
for various illnesses.
Researchers already envision transplanting ready - made embryonic
stem cells back into people, providing cures
for a huge range of diseases, from diabetes to paralysis to Alzheimer's.
Scientists reeling from the revelation that South Korean
researcher Hwang Woo Suk's
stem cell work was fraudulent are scrambling to revive the golden promise of the field and make up
for lost time.
«It is sobering,» says George Daley, a
stem cell researcher at Harvard Medical School who has helped write guidelines
for people considering
stem cell treatments.
That message, delivered in two studies published today, is both good news and bad news
for researchers who hope to use so - called induced pluripotent
stem cells (iPS
cells) to study diseases and perhaps some day treat patients.
The
researchers transformed
stem cells into red blood
cells, which allowed them to conduct a genetic screen
for host determinants of P. falciparum infection.
In the paper, the
researchers show
for the first time that ANG simultaneously reduces proliferation of
stem cells and promotes proliferation of myeloid progenitor
cells that give rise to mature myeloid
cells.
And it suggests that
stem cells derived from embryos should remain the primary reference
for iPS
cells when
researchers want to compare how
cells from diseased patients behave, says Nissim Benvenisty of Hebrew University of Jerusalem, who has studied differences between ES
cells and iPS
cells derived from carriers of fragile X syndrome.
Researchers have harnessed the CRISPR - Cas9 technology to correct mutations in the blood
stem cells of patients with a rare immunodeficiency disorder; the engineered
cells successfully engrafted in mice
for up to five months.
Exploiting the same pre-clinical model used
for their studies, the
researchers are testing the efficacy of this kind of drug candidates against cancer
stem cells, and the possibility of identifying combination regimens with standard chemotherapies with minimized toxic effects, with the perspective of their possible application
for the treatment of human breast cancer.
Those hoping
for quick clinical success should remember it takes time
for revolutionary treatments to go from lab bench to bedside, says Andras Nagy, a
stem cell researcher at Mount Sinai Hospital's Lunenfeld — Tanenbaum Research Institute in Toronto, who has not been directly involved in Yamanaka's work.
► In a Thursday ScienceInsider, Kelly Servick reported that the case brought by heart
stem cell researchers Piero Anversa and Annarosa Leri «against their institution,» Harvard Medical School and its affiliate, Brigham and Women's Hospital (BWH), «
for allegedly mishandling a misconduct investigation was dismissed by a federal judge in Massachusetts this week.
For the purpose of additional experiments, the
researchers generated myocardial
cells from embryonic
stem cells and human skin
cells, in collaboration with the lab headed by Prof Dr Jürgen Hescheler at the University of Cologne.
Now, a team led by neurotransplant
researcher Ole Isacson of Harvard Medical School in Boston reports that
stem cells can compensate
for some Parkinson's - like damage in animals.