Catalent Pharma Solutions, Somerset, NJ 10/2004 — Present Scientist, Analytical Services Perform laboratory investigations
for aberrant / atypical and OOS results.
On - device processing of AI applications can also increase both the device and data security by maintaining a watchful eye
for aberrant behavior.
* Our ongoing study now includes over 1500 cases of dogs presented to veterinary clinics
for aberrant behavior.
MPAA Rated: Not rated, but originally NC - 17
for aberrant sexual content, explicit dialogue, disturbing thematic material, violence, and drug content Running Time: 134 min.
Raw ⋆ ⋆ ⋆ 1/2 out of four stars Rated: R
for aberrant behavior, bloody and grisly images, strong sexuality, nudity, language and drug use / partying.
MPAA Rating: (
for aberrant behavior involving nudity, violence, sexuality, and disturbing images)
MPAA Rated: R
for aberrant behavior involving nudity, violence, sexuality, and disturbing images Running Time: 147 min.
R (
for aberrant behavior, bloody and grisly images, strong sexuality, nudity, language and drug use / partying)
Blood founder cells showed a much lower propensity
for aberrant methylation than did other founder cells, which could explain why in the past scientists attributed the founder cell to the effectiveness of differentiating iPS cells to the hematopoietic lineage.
Monstera deliciosa, a tropical plant named
for its aberrant leaf shape and tasty fruit, makes the most of the sunshine it receives with the unusual perforations in its leaves.
The mutated gene, FAA, codes
for an aberrant, as - yet - unnamed protein that initiates a cascade of malfunctions in various body systems, including production of blood cells and platelets in the bone marrow.
To acquire new insights into the biology and possible therapy of these tumors, Feigin et al. looked
for aberrant expression of G protein — coupled receptors, cell signaling proteins that have been successfully targeted for treatment of other disorders such as depression.
Secondarily, there are «concentration effects,» a tendency
for aberrant behaviors such as crime and illegitimacy to flourish in the ghetto because of its isolation from mainstream society.
The simplified explanation
for this aberrant investing disaster was a dramatic rise in interest rates during the period: Rates on long - term government bonds went from 4 % at year - end 1964 to more than 15 % in 1981.
Not exact matches
It got Buffett's attention because in 1999 the U.S. stock market has just finished two wildly different — and
aberrant — 17 - year periods that Buffett realized could be the framework
for a speech.
For those of us who were already adults when that occurred, it was shocking both because of its devastation and because of how
aberrant it seemed.
It's just a poor «fall guy»
for the real reasons behind any
aberrant behaviors.
Their
aberrant behavior challenged the daily ritual which had been an expression of faithfulness
for generations.
Although surveyors of the religious scene have been mentioning the Mormons
for almost as long as Mormonism has been in existence, their reports have always placed the Saints outside the mainstream, treating them as a sort of
aberrant footnote to the nation's religious life.
For all its economic power, American Catholicism is only one minor and rather aberrant party within the worldwide communion; and Francis is writing for his Church, not for Ameri
For all its economic power, American Catholicism is only one minor and rather
aberrant party within the worldwide communion; and Francis is writing
for his Church, not for Ameri
for his Church, not
for Ameri
for America.
He does not mind admitting ponderously that he is an atheist and that the Bible is responsible
for his son's
aberrant behavior.
There are certainly many theologically
aberrant groups in Africa (and around the world), but often African Anglicans are respected
for their passion
for liturgy, the word, and the spirit.
Some of his interpretations of the word are incredibly far from the original intent, and I think IHOP has become a place
for legalism and
aberrant spirituality, like mysticism through contemplative prayer, etc..
Too many Pentecostal organizations lack any structure
for safe criticism of dysfunctional behavior,
aberrant teaching or abusive practices on the part of leaders and powerful ministers.
His old, unstable life was marked by enough
aberrant events to keep Andy Sipowicz busy
for a full season of NYPD Blue.
Even after you stop taking the pill, you may experience
aberrant menstrual cycles
for three to six months.
The researchers concluded from these findings that
aberrant activation of cyclin E / Cdk2 oncogenic signaling is essential
for maintaining and expanding the CD44 + / CD24 - / Low subpopulation in inflammatory breast cancer.
This work provides a proof of principle
for a new approach in the study and treatment of cancer: the
aberrant expression in a tissue or organ of genes specific to other tissues could become a new tool
for establishing a prognosis and personalizing therapeutic care.
For the new study, O'Rourke and his colleagues designed a CAR targeting an
aberrant protein called EGFRvIII that is present in roughly 30 % of glioblastomas and is thought to promote malignancy.
Christianson said his team uses neuroscience techniques «to investigate the biological basis
for social cognition with the hope that we can better understand and treat people with conditions marked by
aberrant social cognition such as autism or schizophrenia.»
Christianson said the findings set the stage
for a large - scale investigation of the brain circuits that work together to orchestrate responses to social emotional information with the hope that such research will lead to better treatment
for people with conditions marked by
aberrant social cognition, such as autism or schizophrenia.
«Understanding the mechanisms that promote
aberrant neurogenesis caused by traumatic brain injury and subsequent seizures may open new therapeutic avenues to prevent epilepsy and associated memory problems caused by impact,» said senior author Dr. Jenny Hsieh, Associate Professor of Molecular Biology and a member of the UT Southwestern Hamon Center
for Regenerative Science and Medicine.
The post-synaptic density is a specialized area full of proteins needed
for communication between neurons, so changes in its structure or capacity may explain the
aberrant electrical responses.
«
For a cell,
aberrant activation of autophagy could easily have lethal consequences.»
Poulos added, «Future experiments in our laboratory will allow us to determine if this increase in glucocorticoid receptors within the amygdala and / or
aberrant hormone levels sets up the organism
for increased fear and anxiety.»
«
Aberrant splicing in humans may lead to various complex diseases and also underlies the development of some forms of cancer and the onset of neurodegenerative diseases, so a better understanding of the process can add important information
for our fight against these diseases.»
A better understanding of
aberrant brain receptor signaling that leads to nerve cell dysfunction could reveal a target
for therapy, according to the authors.
«What is exciting about this study is that it goes beyond correlation and shows causation, because we demonstrated
for the first time that
aberrant expression of this protein is sufficient to induce pathology.»
«More importantly, these findings encourage the search
for personalized music - based interventions
for the treatment of brain disorders associated with
aberrant dopaminergic neurotransmission as well as abnormal mood and emotion - related brain activity.»
Defective mRNAs will result in
aberrant, potentially harmful proteins; an efficient process
for recognizing and disposing of such mRNAs is therefore essential.
The current discovery that MAX acts as a tumor suppressor in lung cancer provides evidence that an
aberrant SWI / SNF - MYC / MAX network is essential
for lung cancer development.
They found that by elevating the activity of PV - GPe neurons over the activity of the Lhx6 - GPe neurons, they were able to stop
aberrant neuronal behavior in the basal ganglia and restore movement in the mouse model
for at least four hours — significantly longer than current treatments.
In addition to p53, there are other transcriptional activatory mechanisms that are not well understood
for the most part and which operate in response to mitogenic stimulation (11, 12), transforming growth factor - β (13, 14, 15), and
aberrant oncogenic signals (16, 17) or during a number of cell differentiation processes (18, 19).
The gene encodes a protein called plakophilin 2, which is crucial
for the formation and proper functioning of the skin structure, suggesting an
aberrant skin barrier as a potential risk factor
for atopic dermatitis.
Aberrant expression of TUBB3 has also been found in various tumors of non-neural origin and can be used as a biomarker
for cancer aggressiveness and a marker
for the tendency to respond poorly to chemotherapy.
In addition to being integral to cell biology, tyrosine kinases also present targets
for new anticancer therapies: One of the most highly touted, rationally designed anticancer compounds, Gleevec, inhibits an oncogenic tyrosine kinase whose
aberrant activity fuels the rampant growth of cells in patients with chronic myeloid leukemia.
«This gives us a target to work on,» Young said at a press conference in New York this morning, alluding to the possibility that this basic research discovery may lead to a possible way to intervene in the
aberrant pathway and fix it, enabling people who suffer from the condition to adhere to a normal sleep schedule without the need
for sleeping pills.
Errors in chromosome segregation are a major cause
for birth defects and embryonic lethality in humans, and the most common genetic alteration in human tumors is
aberrant chromosome numbers, called aneuploidy.
Career Goals: Peipei is passionately building up her career as professional research investigator to continue unraveling the mystery of
aberrant myelopoiesis with the goal of developing new generation of therapeutic method
for cancer & cardiovascular disease.
In the article describing the work in Molecular Therapy, co-authors Charis Himeda, Takako Jones and Peter Jones highlight the important implications
for similar types of genetic diseases: «With increasing evidence that the repeat genome (comprising nearly half the human genome) plays important roles in gene regulation, additional diseases will likely be found associated with
aberrant repetitive genomic sequences,» they write.