Not exact matches
These risks and uncertainties include: Gilead's
ability to achieve its anticipated full year 2018 financial results; Gilead's
ability to sustain growth in revenues
for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement
for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding
for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's
ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's
ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's
ability to submit new drug applications
for new product candidates in the timelines currently anticipated; Gilead's
ability to receive regulatory approvals in a timely manner or at all,
for new and current products, including Biktarvy; Gilead's
ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's
ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in
combination with Pfizer's utomilumab; Gilead's
ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).
The
combination of both more traditional perspectives about the category, combined with Ollie's desire and
ability to raise the bar on product, marketing and distribution innovation, has enabled the company to make the best possible choices
for its products and its customers, both two - and four - legged!»
The
combination of lower tariffs, non-tariff market access measures and having one set of rules
for trade with 10 economies with the
ability to build new supply and production chains across the TPP adds up to a significant advantage
for Canadian companies over competitors in the U.S. and Europe.
The
combination of a very intuitive user interface, an export - to - csv - button on * every * page and the
ability to zoom in to nearly anything you could think of to analyze, makes it an invaluable tool
for anyone who takes link building seriously.
The catalyst
for me was a
combination of things: I was exhausted from all the work it took to live a lie; I sensed that my
ability to stay in control of my secret was lessening and I was getting sloppy; my life had become unmanageable.
Other quality control solutions on display include latest developments in X-ray and checkweigher technology; multihead weighers on show comprise Ishida's latest and most advanced RV series, its revolutionary solution
for handling sticky meat, and its advanced iTPS weigher and bagmaker
combination for snacks; and Ishida's mid-range tray sealer will demonstrate the company's
ability to maximise product freshness while delivering high quality pack presentation.
I find that sweet potatoes provide a sweet foundation
for innumerable flavor
combinations, yet they are just as delicious on their own thanks to their natural
ability to caramelize when baked.
With this
combination of visibility and the
ability to take action, Ben E. Keith will be able to respond preemptively to cost issues, know which freight it should manage versus suppliers, plan
for «what - if» scenarios and continue to provide quality fresh product with higher inventory turns.
The
combination of fast - digesting whey proteins with slow - acting casein proteins is essential
for athletic recovery because of its
ability to provide a constant flow of amino acids and the essential nutrients needed to replenish a body and maximize post workout recovery while building and repairing lean muscles.
The
combination of all of these technologies gives TOMRA Sorting Tobacco the
ability to provide the most tailored, cost - effective and advanced sorting solutions
for the efficient removal of NTRM from threshed leaves all the way to the final product.
Arsene Wenger has been speaking to Arsenal Player about the hard fought win at Crystal Palace, paying tribute to the efforts of Alan Pardew and his players, while declaring that the Gunners got what we deserved
for playing with a
combination of football
ability and determination.
The attacking pair may not have the best
combination of
abilities to form the ideal partnership, but there is the thought that the French striker may well be suited to playing alongside another attacker, and they could well be perfectly ideal at creating the necessary space
for each other, and with Mesut Ozil and Wilshere behind doing the creating, the duo could become feared throughout the division.
Of course, his versatility is what makes this prospect particularly interesting; as he presents the
ability to offer support as a «number 10» or function perfectly as a «number 9» so tactically offers many attacking
combinations which Arsenal have lacked
for years (I mean lets be honest most of us can name Arsenal's starting lineup in our sleep).
Each sport requires a different
combination of power (the
ability to produce energy very fast «'' low efficiency) and endurance (the
ability to produce energy slowly
for a long period of time «'' high efficiency).
We are not able to verify the legality of the information we provide, or your
ability to use any sites that are linked to on this site,
for every
combination of your location, the sites» location, and the type of service those sites provide.
The
combination of this size, burst and perfect technique made him near unplayable and were it not
for his
ability to miss sitters we could have easily been looking at Golden Boot numbers.
Michael Laudrup was
combination of everything that is essential
for midfielder; he had the passing
ability, the touch, and the vision.
For all of his immense
ability a
combination of factors — injury, a new position and his relative youth among them — means he has had a tendency to float through some games, failing to stamp his authority in the way that a player like Fabregas does.
* Vitamin - E and purified grape polyphenols: work synergistically
for enhanced protection against free radicals * Ectoin: protects against environmental aggressors and accelerates the skin's
ability to repair itself * Flavonols derived from jasmine: limit inflammation * Capriloyl salicylic acid: induces efficient exfoliation of dead skin cells to give skin a smoother texture * Selective
combination of proven emollients and humectants: restores proper balance of skin hydration and skin lipids
For engineering, the applications of the hybrid rubber that take advantage of its exceptional
combination of optical transparency, toughness, and self - healing
ability remain to be explored.
The AUC
for those patients was 0.87
for Stage I / IIA, 0.93
for Stage IIB and 0.89
for all early stages of the disease using the
combination, pointing to a potential
ability to detect disease in those who lack either of those known risk - raising conditions.
Testing each of these factors
for their
ability to return differentiated tumor cells to a stem - like state, identified a
combination of four — POU3F2, SOX2, SALL2 and OLIG2 — that was able to reprogram differentiated tumor cells back into glioblastoma stem cells, both in vitro and in an animal model.
A group of nuclear power experts and former regulators from 11 nations, responding to Japan's nuclear disaster, is calling
for «stress tests» on the world's reactors to determine their
ability to withstand extreme earthquakes, flooding or other natural disasters that strike singly or in
combination.
PORPOISES have the
combination of acoustic controls built into their heads to thank
for their
ability to focus a directed beam of sonar on prey.
The new study accounts
for the
combination of temperature and humidity, which reduces the human body's
ability to cool itself through evaporation of sweat.
«That
combination of both storing more stress and the
ability for it to propagate farther is important
for both generating large earthquakes and
for propagating to very shallow depths,» said Nathan Bangs, a senior research scientist at UTIG and study co-author.
Thus, the Frontier Fields use Hubble's own magnifying
abilities in
combination with the serendipitous magnification offered by gravitational lenses to look
for the farthest objects ever glimpsed.
But
for those with the right
combination of
ability, ambition, and intellectual interests, the lure of academic success may well be worth the risk and the hard road to get there.
Through a
combination of single - molecule imaging and bulk biochemical experiments, the research team has shown that the genome - editing
ability of Cas9 is made possible by the presence of short DNA sequences known as «PAM,»
for protospacer adjacent motif.
«The
combination of iSHELL's high resolution and the
ability to observe in the daytime at IRTF is ideal
for studying comets, especially short - period comets,» said John Rayner, director of the IRTF, which is managed
for NASA by the University of Hawai'i.
Scientists report in the May 9 Science Translational Medicine that seven of 12 diabetic mice treated with this
combination were cured even after having lost the
ability to make insulin
for several weeks, the equivalent of a human patient who has needed insulin injections
for a couple of years.
Through a
combination of a variety of information gathering activities and Committee deliberations, the Committee has concluded that the nation's need
for these scientists remains strong and that the NRSA program, while small compared to the many other sources of doctoral and postdoctoral support, is enormously powerful in terms of its
ability to change research emphases and to attract the highest quality individuals to research careers in the basic biomedical, behavioral and clinical sciences.
Many materials are known
for just one characteristic magnetic or electrical property, or
for having the
ability to change shape, but multiferroics contain some
combination of these attributes.
The assays presented here demonstrate a rapid and simple system
for testing individual and
combinations of intrinsic and extrinsic factors
for their
ability to direct pluripotent cells to multipotent retinal cells, with the option of testing them functionally.
It is the only top - ten magnesium food that also is known
for its
ability to promote neurotransmitter activity and dopamine production, so this
combination makes it especially desirable during hormone imbalance.
Why you would: Ordinarily exercise uses a
combination of glycogen (carbohydrates) and fat as fuel, but according to a recent study published in Sports Medicine, exercising in a fasted or glycogen - depleted state causes adaptations in the body's fat - oxidising
abilities, causing the body to use fat
for fuel.
This
combination may enhance your alertness, motivation, memory and
ability to focus, another reason athletes often opt
for bananas during water breaks.
This translates into the
ability to utilize the club
for more advanced
combination routines and flow sequences... the limitations to its use are only a function of your skill and imagination.
• Attend a Yoga Alliance Registered School with internationally recognized teaching professionals • Learn simple strategies to discover your true gift • Experience a
combination of Western Science with Eastern Wisdom
for the Modern Yogi • Transform a vision into a mission • Have fun and be connected with wonderful people • Learn to teach asanas (postures) with ultimate balance between the physical and the spiritual • Learn to teach modified versions of asanas (postures) with the help of props • Discover relevant and in depth mechanics of human anatomical systems supported by a dynamic multi-media presentation, worksheets and practical demonstrations • Learn a unique flow style of yoga, suitable
for all levels; not just the physically fit and advanced • Master completely safe, injury preventative teaching instructions • Learn extremely precise and detailed teaching linguistics • Learn how to create simple yet complex yoga flows to guide those with different needs and
abilities • Get ample opportunity
for practicing teaching skills in front of live students and apply the skills learned in our teacher training in your practica with the help of an experienced, professional mentor.
Mandates
for children are particularly disturbing as studies show children are at far greater risk from aluminum adjuvants because of the
combination of rapid growth, an incomplete blood - brain barrier and limited
ability to eliminate toxins.
With its
ability to enhance the complexion and provide the skin with a natural - looking glow, paired with its nourishing and hydrating properties, this sheer coverage foundation is ideal
for oily or
combination skin types.
The
combination of Jill's passion
for motherhood, her sense of humor, her wit, her
ability to lay it all out there, and the advice she gathered from other mamas that she had contribute to the book make this an absolute MUST HAVE book.
The
combination of her
ability to empathize with others and the constant support from her family pushed her to create Monica + Andy, a company
for baby clothing that personalizes each purchase and emulates the special experience of being a mother (She's also about to start a podcast to encourage fellow female entrepreneurs — is there anything she can't do!?).
Combination of excellent conceptual and strategy skills with an
ability to take responsibility
for projects and lead team members.
It's SkaDate's most effective (and thus most popular) option and is right
for those who want a
combination of website and mobile apps working together, with further
ability of customization.
With characters like Blast Zone and Wash Buckler, you could create a character called Blast Buckler or Wash Zone
for some very interesting
ability combinations.
However where the title does come into its own is the
ability to create over 100 multiplayer map
combinations with just 9 unique maps with some decent customisation options
for your characters as well.
Fortunately, Ryan Reynolds»
combination of suave self - assuredness, seasoned comic timing and old - fashioned
ability to kick butt outweigh the film's minor flaws to make
for a satisfying cinematic experience warranting a sequel.
The
combination of voice recording and images promotes speaking skills and is a great choice
for classrooms with students of mixed
abilities.
This is a
combination of resources
for the higher and lower
ability Y...