Sentences with phrase «for additional genes»

«When we injected GMT into each of the three types of human fibroblasts, nothing happened — they never transformed — so we went back to the drawing board to look for additional genes that would help initiate the transformation,» said Gladstone Staff Scientist Ji - dong Fu, PhD, the study's lead author.

The discovery should speed the search for additional genes that increase susceptibility to autism and enhance understanding of this complex disorder.

Testing for additional genes in the pathway and in a number of pathways is done through a number of commercial resources; the only other clinically relevant test is the homologous recombination defect assay, which is commercially available from Myriad Genetics.

Here we show that these cells exhibit decreased mRNA levels for additional genes contributing to telomere metabolism, but also, surprisingly, for 12 genes mutated in Fanconi anaemia.

Not exact matches

The first steps in this have already been accomplished with the transplanting of additional genes for growth hormone into sheep in Australia to produce larger animals and therefore more wool.

The researchers identified several reasons for this: The new gene constructs interfere with the plant's own gene for producing growth hormones, and the additional gene constructs were not, as intended, active solely in the kernels, but also in the leaves.

After finishing the survey, participants in the study can opt for an additional study and consider submitting DNA collected by a cheek swab to be tested for variants at the Apolipoprotein E (APOE) gene.

What if these «maternal sensitivity» genes have the additional, independent effect of making it easier for children to develop strong executive function skills?

The researchers then found that these same genes carry an additional risk for a phenomenon called spreading depolarization, a slowly - progressing, temporary electrical blackout of a region in the brain.

Jaenisch says that the method that identified the single point mutation in SNCA's enhancer could be used to pinpoint additional pathogenic genes for sporadic PD and sift through the GWAS hits for other diseases, including Alzheimer's disease, cancer, diabetes, and multiple sclerosis.

Apparently, NPAS4 accounts for some addiction - related learning and memory processes in the brain, but not all of them, meaning that HDAC5 must be regulating additional genes that reduce relapse events.

In an additional group of endometriosis samples biopsied from 15 women at the University of British Columbia, the scientists looked specifically for mutations in the KRAS gene, whose expression signals proteins that spur cell growth and replication.

Note added in proof: Additional evidence for CA1 - CA3 differences is provided by a recent study measuring immediate early gene activation in two different novel rooms (36).

The IGF1 protein is crucial for the growth of mammals, including mice and humans, so Ostrander's group and other collaborators began collecting DNA from additional breeds to see if they also shared the same gene variant.

Before the consortium came together, he had participated in sequencing the genomes of two vocal learners, a songbird and a parrot, but he knew he couldn't do all of the additional sequencing and analysis work that would be required to identify genes related to vocal learning — not by himself, at least — so he teamed up with Genome 10K, a project aiming to collect genomes for 10,000 vertebrate species.

Because environmental exposures have not had time to impact IBD progression in children, researchers have a clearer genetic picture of the disease allowing them to pick out additional genes overlooked in adult research, says senior study author Hakon Hakonarson, director of the Center for Applied Genomics at The Children's Hospital of Philadelphia.

Many of the additional 38 missing genes looked like they coded for proteins involved in controlling the activity of other genes.

The researchers scoured the already deciphered mouse genome, looking for genes that might encode additional receptor proteins in its olfactory system, the sensory cells that connect the nose to the brain.

Additional experiments showed that the protein produced by HMGA1 activates another gene called Sox9, which is directly responsible for turning stem cells into Paneth cells.

Additional support could come from the chimpanzee genome, which may allow researchers to clock when the genes for slow - twitch muscle fibers — crucial for running long distances and plentiful in people but not chimps — diverged in the common evolutionary history of humans and apes.

«Additional studies are needed to see if these nanoparticles could also effectively deliver other antitumor genes for the treatment of brain tumors as well as systemic cancers.»

«This knowledge will facilitate identification and isolation of additional resistance genes for improved control of Septoria,» adds Kanyuka.

The authors will follow up the study with additional worldwide populations to better understand the mutations and these genes as a genetic marker for disease risk.

Also, future studies could identify additional longevity genes by recruiting more centenarians for analysis.

Next they tested an additional 27 genes that are known to be involved in various steps of ribosome biogenesis to verify whether SSUP was required for ESC maintenance.

Center for Elephant Conservation, elephants have 38 additional modified copies (alleles) of a gene that encodes p53, a well - defined tumor suppressor, as compared to humans, who have only two.

The social velvet spider's genome, however, revealed 10 genes just for that one kind of silk and nine other genes for additional silk proteins.

If a woman with a strong family history of breast and ovarian cancers tests negative for the BRCA1 / 2 genes, that does not mean her relatives are not at risk, says Daly — her siblings could still carry the gene, or there could be additional genes present that predispose them to cancer that clinicians don't yet know how to test for.

But in a polyploid organism such as wheat, mutations in individual genes often have no apparent effect, because additional copies of the mutated gene compensate for the loss.

Scientist from the MPI for Heart and Lung Research in Bad Nauheim now found that additional genes compensate for a knocked out gene and either attenuate consequences or completely compensate deficits.

«The computer model predicts that by altering this system by up - regulating some genes and down - regulating others, a 60 percent improvement could be achieved without any additional resource — so 60 percent more carbon could be assimilated for no more nitrogen,» Long said.

They think these additional genes paved the way for colorful and more structured and shapely flowers in later evolving angiosperms.

* For a description of additional methods used by Green et al. to detect gene flow between Neandertals and modern humans, see the News story by A. Gibbons.

This additional sequencing information, the researchers observed, greatly improved gene annotation for that species of gorilla.

Roberts hopes the additional subjects will help his group narrow the search for a specific gene.

Overall, the new study suggests that genetic variations in the gene that codes for POU6F2 may affect the structure of the eye and increase a person's risk of glaucoma, but additional studies will be needed to describe the exact mechanism.

Thus we can conclude that mutations occurred in the CDR3s during the protein immunization phase resulting in neutralization ability, alongside additional mutations in the V gene which are required for breadth at least in the A14 / B9 lineage.

SNPs in the human IL15 and IL15RA genes have been associated with muscle phenotypes (16), muscle responses to resistance training (17), metabolic syndrome (16), and obesity (18 — 20), providing additional rationale to support a role for these molecules in muscle.

She identified that specific killing of myeloid cells represents an additional mechanism of suppression mediated by Tr1 cells, and she contributed to the definition of a new protocol for Tr1 cell induction using IL - 10 gene transfer and in the discovery of the biomarkers of Tr1 cells.

$ 2,500 «Beyond bacteria» Deeper shotgun metagenome and virome characterization of one sample, plus additional marker gene sequencing (16S rRNA, 18S rRNA and ITS, for you sequencing wonks) to characterize not just the bacteria but also the viruses, microbial eukaryotes (like giardia), and fungi in your gut.

GOMiner — To provide additional statistical stringency to the identification of potential targets, we then analyzed the data sets generated by the SAM - RS analysis of the microarray data for hypoxia - associated coregulation of multiple, functionally related genes.

Any additional embryos that are free of genetic problems are kept frozen for possible later use while embryos with the problematic gene (s) are destroyed.

Additional experiments showed the feasibility of creating a two - layer security system for T cells by simultaneously blocking a gene the HIV virus needs to gain entry into cells and a gene the virus needs to survive and reproduce within the cell, resulting in doubly secure resistance.

«We think we can get additional benefits using the intellectual property for the genes provided by multinationals,» says director general Thomas Lumpkin.

It may provide an exciting additional target for further gene and drug discovery.

The researchers caution that follow - up studies must be done over a longer period and with additional subjects before they can definitively state that re-administering gene therapy for retinal disease is safe in humans.

In 2009 and 2010, however, researchers confirmed additional gene variants of CR1, CLU and PICALM as possible risk factors for late - onset Alzheimer's.

This effort, which will enhance deCODE's proprietary gene and drug target discovery work and may provide genetic markers for additional diagnostic development, will leverage Illumina's Sentrix ® HumanHap BeadChips; Infinium ™ assay and LIMS (laboratory information management system); as well as analysis and visualization tools from Illumina's BeadStudio software.

As mRNA isolation is simple and since DNA microarrays are a proven genomics reagent for monitoring differential gene expression, a genome - wide expression analysis may be the fastest and most efficient method for identifying additional candidate effectors of colony queen number.

With the reference cell census data in hand, the research team is excited to conduct additional studies, including ones involving models or human patients with gastrointestinal conditions — Crohn's disease, ulcerative colitis, gastrointestinal cancers, forms of food allergy, etc. — aimed at identifying changes in gene expression and epithelial structure and function that could reveal new insights and opportunities for therapeutic development.