Sentences with phrase «for aggregated proteins»

Not exact matches

A genetic cure for the disease would require completely replacing the mutated gene because any remaining dysfunctional protein would continue to form damaging aggregates.

Very large aggregates can be formed from protein subunits, for example many thousand actin molecules assemble into an actin filament.

Optineurin is involved, for example, in the elimination of aggregated proteins and bacterial infection defense.

Once CAT - tailed proteins are imported into the mitochondria, they form aggregates that may act as a seed, and ultimately bind proteins free of defects that have vital roles for the cell» explains Toshiaki Izawa, first author of the study, together with Sae - Hun Park.

Hartl has been investigating protein aggregates, a cellular cause of neurodegenerative diseases, for many years.

While these compounds did not reduce the amount of protein aggregates, they were found to reduce the protein's toxicity and to increase the stability of amyloid fibrils — a finding that lends further evidence to the theory that smaller assemblies of amyloid - beta known as oligomers, and not the fibrils themselves, are the toxic agents responsible for Alzheimer's symptoms.

Huntington's disease, for example, is caused by aggregating proteins inside brain neurons that ultimately lead to motor dysfunction, personality changes, depression and dementia, usually progressing rapidly after onset in people's 40s.

Key to this process is a repetitive stretch of a protein building block called glutamine, which is known to serve as a glue for protein aggregates in disease.

«We already know from previous studies on the protein huntingtin, which spontaneously forms aggregates and is responsible for the development of the neurodegenerative disorder Huntington's disease, that protein aggregates also bind to essential proteins that have no defects.»

The report stated that «there is a reasonable certainty that no harm will result from aggregate exposure to the United States population, including infants and children, to the CryIA (b) protein and the genetic material necessary for its production.

«Our results not only demonstrate a potential mechanism for the development of neurodegenera - tive disorders but we have also found another example of the way in which proteins can form aggregates and damage the cell.

Previously, researchers have shown that treating cells with neuregulin - 1, for example, dampens levels of amyloid precursor protein, a molecule that generates amyloid beta, which aggregate and form plaques in the brains of Alzheimer's patients.

Patrik Verstreken (VIB / KU Leuven): «We have set up a new in vitro system specifically for this research, to enable us to study the distribution throughout the brain of aggregate proteins that are typical of neurodegenerative diseases.

«The TTR protein has a tendency to misfold and then aggregate, which for some reason seems to occur in children with JIA,» said Dr. Santambrogio.

Scientists at the Stowers Institute for Medical Research have made a surprising finding about the aggregates of misfolded cellular proteins that have been linked to aging - related disorders such as Parkinson's disease.

When isolated and tested for their response to heat, these proteins readily aggregated.

For example, it helps to remove proteins that fail to fold properly, which would otherwise form harmful aggregates.

A detailed analysis of this mechanism will be crucial to understand how aggregate - forming proteins lead to human diseases and may help to develop concepts for possible disease preventions.

We used this paradigm following the field of neurodegenerative disorders associated to protein misfolding, in which a widely established method for studying propagation of protein aggregates in vitro consists of exposing cell lines to specific protein aggregates.

The newly identified proteins, termed CUET proteins (for Cue5 / Tollip adaptors; shown in red), recognize pathological protein aggregates (cellular waste), including those of human neurodegenerative diseases.

For that purpose, we used aggregates of the Tau protein, implicated in Alzheimer's disease, as well as the bacterial amyloid protein microcin (Mcc).

Isolated islets from 3 - wk - old Tg - hIAPP, which do not exhibit IAPP aggregates at that age (Janson et al., 1996), were cultured in the presence of 1 % or 0.1 % islets extracts from old Tg or WT mice for 7 d under standard conditions, including a glucose concentration of 11 mM in the medium to reduce glucotoxicity and spontaneous aggregation of the protein (Zraika et al., 2007).

AEC syndrome caused by pathological protein aggregates / Research lays groundwork for causal therapies.

AFM (2015 - 2016): Régulation of protein aggregation trough NBR1 and P62 phosphorygation: implication for protein aggregate myopathies

They also work as garbage collectors, chewing up dead cells and molecular debris strewn among living cells — including clusters of a protein called A-beta, notorious for aggregating into gummy deposits called Alzheimer's plaques, the disease's hallmark anatomical feature.

Lysosomes are responsible for the turnover and clearance from cells of damaged organelles and protein aggregates.

For studies at the molecular level, Ismagilov will develop microfluidic systems capable of rapidly generating, manipulating and assaying protein aggregates of various sizes, shapes and compositions.

A comparison of the absorption and corrected excitation spectra of the Amrose proteins suggests the presence of a certain amount of non-emissive dimers or aggregates as shown in Figure 3 exemplarily for Amrose v1, indicated by the mismatch of the signals on their short wavelength side.

The crystallins, which make up over 90 % of the proteins in the lens, are specially adapted to contribute to the maintenance of transparency by forming soluble, high - molecular weight aggregates that need to stay in solution for the duration of an individual's life.