Sentences with phrase «for aggressive breast cancer»

Researchers developing model to predict if chemotherapy will work for aggressive breast cancer

In the study, the genetic targets were messenger RNA (mRNA) that code for certain proteins known to be biomarkers for aggressive breast cancer cells.

Geminin overexpression promotes imatinib sensitive breast cancer: A novel treatment approach for aggressive breast cancers, including a subset of triple negative

Not exact matches

The other, a former White House aide to President Obama, tested positive for the BRCA2 gene mutation that has led to breast cancer in her family for generations — and is taking aggressive steps to avoid the same fate.

The woman asking this of her sister had been in an out of the hospital struggling with an aggressive breast cancer for three years.

She carried in her cells a dangerous genetic mutation and died when she was 28, after refusing surgery for her aggressive, inherited breast cancer.

«Our discovery of these mutations is a first step in developing a genetics - based system for classifying endometriosis so that clinicians can sort out which forms of the disorder may need more aggressive treatment and which may not,» says Ie - Ming Shih, M.D., Ph.D., the Richard W. TeLinde Distinguished Professor in the Department of Gynecology & Obstetrics at the Johns Hopkins University School of Medicine and co-director of the Breast and Ovarian Cancer Program at the Johns Hopkins Kimmel Cancer Center.

«This study forms the basis for future research in patients with breast cancer and offers hope for targeted therapy for patients with aggressive triple - negative inflammatory breast cancer,» said lead researcher Mateusz Opyrchal, M.D., Ph.D., Assistant Professor of Oncology at RPCI.

PARP inhibitors have shown efficacy for a small group of patients with breast cancer with inherited mutations in BRCA genes, but have failed in the more aggressive triple - negative disease.

«New inhibitor brings new hope for aggressive triple receptor - negative breast cancer.»

«Our data clearly suggests that AKR1B1 overexpression represents an oncogenic event that is responsible for the aggressive behaviors of basal - like breast cancer cells,» Dong explains.

Women who pursue a more aggressive surgery for early stage breast cancer have nearly eight times the odds of reporting substantial employment disruptions, according to a new study from University of Michigan Comprehensive Cancer Center researcancer have nearly eight times the odds of reporting substantial employment disruptions, according to a new study from University of Michigan Comprehensive Cancer Center researCancer Center researchers.

The team therefore analyzed the case history of 890 breast cancer patients and found that low Numb - 1 and -2 levels correlated with an increased risk of aggressive, metastatic disease, particularly for the luminal subtype of breast cancers, which tend to retain a normal, functional copy of the p53 gene.

A team of researchers led by UC San Francisco scientists has identified a new drug target for triple - negative breast cancer, an aggressive disease subtype that has the poorest outcomes and accounts for as many as one in five cases.

«It's incredibly encouraging to find possible new options for patients with an aggressive cancer like triple negative breast cancer, and that studies conducted by separate teams at leading institutions agree on the implications of the findings,» said Alan Ashworth, PhD, FRS, president of UCSF Helen Diller Family Comprehensive Cancer Center, and former CEO of thcancer like triple negative breast cancer, and that studies conducted by separate teams at leading institutions agree on the implications of the findings,» said Alan Ashworth, PhD, FRS, president of UCSF Helen Diller Family Comprehensive Cancer Center, and former CEO of thcancer, and that studies conducted by separate teams at leading institutions agree on the implications of the findings,» said Alan Ashworth, PhD, FRS, president of UCSF Helen Diller Family Comprehensive Cancer Center, and former CEO of thCancer Center, and former CEO of the ICR.

«The research showed that the aggressive form of basal breast cancer cells may be dependent on PLK4 for survival and that depleting it induced cell death,» says Dr. Mak.

Although prolonged breastfeeding reduces overall cancer risk, women have an increased risk of developing breast cancer for the first 5 to 10 years following pregnancy, and these cancers tend to be more aggressive.

This provides a potential target for treating triple negative breast cancer, the most aggressive form of the disease.

The panel also called for «aggressive research» on using RU486 and other drugs in the antiprogrestin class as contraceptives and as treat - ment for endometriosis, uter - ine fibroids, advanced breast cancer and meningioma brain tumours.

The discovery offers a new treatment option beyond chemotherapy for this aggressive type of breast cancer.

For years, scientists have observed that tumor cells from certain breast cancer patients with aggressive forms of the disease contained low levels of mitochondrial DNA.

In the era of personalized cancer therapy, patients with TNBC remain at considerably higher risk of relapse and death than patients with other breast cancer subtypes, due to the aggressive nature of TNBC and the lack of newer targeted therapies for the disease.

Researchers led by Dr. Debra Auguste, associate professor, biomedical engineering, in the Grove School of Engineering at The City College of New York, have identified a molecule that could lead to developing treatment for one of the most aggressive forms of breast cancer.

His laboratory is investigating genetic markers that predict development of aggressive prostate and breast cancers, and nanotechnology - based therapies for breast and prostate cancers.

My honours project was centred upon exploring mechanisms that allow for the progression of Inflammatory Breast Cancer, a highly rare and aggressive form of advanced breast cancer, and whether we could target these previously unknown mechanisms with novel therapeBreast Cancer, a highly rare and aggressive form of advanced breast cancer, and whether we could target these previously unknown mechanisms with novel therapeCancer, a highly rare and aggressive form of advanced breast cancer, and whether we could target these previously unknown mechanisms with novel therapebreast cancer, and whether we could target these previously unknown mechanisms with novel therapecancer, and whether we could target these previously unknown mechanisms with novel therapeutics.

This model should be a powerful tool for testing therapies for aggressive ER + breast cancers and for studying luminal cancers — the most prevalent and deadliest forms of breast cancer.

They are looking for protein indicators of aggressive breast cancer in the tissue and plasma samples.

Research led by Dr. Carlos Arteaga, Director of the Harold C. Simmons Comprehensive Cancer Center, has identified potential targets for treatment of triple negative breast cancer, the most aggressive form of breast cCancer Center, has identified potential targets for treatment of triple negative breast cancer, the most aggressive form of breast ccancer, the most aggressive form of breast cancercancer.

Low levels of a tiny RNA fragment in cells are associated with metastatic breast cancer in humans and increases the aggressive spread of breast cancer in mice, according to researchers at Whitehead Institute for Biomedical Research.

African American women are more often diagnosed with aggressive, late - stage breast cancers — resulting in mortality rates that are 44 % higher than for Caucasian women.

Together, these data indicate that MELK is a normally non-essential kinase, but is critical for BBC and thus represents a promising selective therapeutic target for the most aggressive subtype of breast cancer.

Many women are «triple negative» No one yet knows precisely why, but African - American women are roughly twice as likely as white women to have triple - negative breast cancer — so called because tumor cells in this particularly aggressive form of the disease test negative for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER - 2).

For this reason, the findings of this 2017 study by the University of Alabama at Birmingham could be incredibly impactful for the treatment of aggressive breast canceFor this reason, the findings of this 2017 study by the University of Alabama at Birmingham could be incredibly impactful for the treatment of aggressive breast cancefor the treatment of aggressive breast cancers.