Sentences with phrase «for aggressive cancers»

In a collaborative effort with UCLA Medical Centre, the goal of this project is to investigate cell nanomechanics, namely cell stiffness or elasticity, and related changes of the actin cytoskeleton as a potential biomarker for aggressive cancers.

In testing multiple HDAC inhibitors in combination with the chemotherapy drug paclitaxel, known to give some benefit for this aggressive cancer, they found that class II HDAC inhibitors signal through a newly discovered pathway to promote synergy with chemotherapy treatment.

The risk for this aggressive cancer increases two to four times.

He did everything he could to save her, including trips out of state for treatments at a nationally recognized hospital best for her aggressive cancer.

Not exact matches

Price recently ended aggressive treatment for his cancer at East Texas Medical Center in Tyler, Texas.

LONDON, Oct 9 - Scientists have found two distinct genetic «signatures» for prostate cancer that may help doctors predict which patients have aggressive tumours, and designed experimental blood tests to read those genetic signs like barcodes.

The other, a former White House aide to President Obama, tested positive for the BRCA2 gene mutation that has led to breast cancer in her family for generations — and is taking aggressive steps to avoid the same fate.

The woman asking this of her sister had been in an out of the hospital struggling with an aggressive breast cancer for three years.

There is at least one approved device and scores of experimental treatments being tested that could improve the odds of longer - term survival for patients with the type of extremely aggressive brain cancer afflicting U.S. Sen. John McCain.

Bob Adair, 61, a carpenter for the Department of Sanitation, said losing his paid days off was a hardship after his wife underwent shoulder surgery and he had treatment for an aggressive form of prostate cancer.

This is especially true for multifocal prostate cancer, less aggressive tumors, and cases of prostatitis or prior prostate irradiation, where MRI alone may not give the correct localization and malignancy grade.»

«This research represents a big step forward in understanding why some tumors are more aggressive than others and being able to predict rationally which neoantigens will be the most effective at stimulating an immune response,» said Dr. Balachandran, a member of the David M. Rubenstein Center for Pancreatic Cancer Research at MSK, and corresponding author of the companion study in Nature.

She carried in her cells a dangerous genetic mutation and died when she was 28, after refusing surgery for her aggressive, inherited breast cancer.

For a cancer with very high genetic diversity (like AML) however, the unintended effect of treatment is often to select for the most aggressive, resistant cells, clearing away their competitors and furnishing them with all the resources they need to flouriFor a cancer with very high genetic diversity (like AML) however, the unintended effect of treatment is often to select for the most aggressive, resistant cells, clearing away their competitors and furnishing them with all the resources they need to flourifor the most aggressive, resistant cells, clearing away their competitors and furnishing them with all the resources they need to flourish.

«Our discovery of these mutations is a first step in developing a genetics - based system for classifying endometriosis so that clinicians can sort out which forms of the disorder may need more aggressive treatment and which may not,» says Ie - Ming Shih, M.D., Ph.D., the Richard W. TeLinde Distinguished Professor in the Department of Gynecology & Obstetrics at the Johns Hopkins University School of Medicine and co-director of the Breast and Ovarian Cancer Program at the Johns Hopkins Kimmel Cancer Center.

«Markers for prostate cancer death can identify men in need of more aggressive treatment.»

This gives us hope for better treatments for this aggressive, hard - to - treat cancer.»

Current treatments for acute lymphoblastic leukemia (ALL), an aggressive form of blood cancer, include conventional chemotherapy drugs that inhibit DNA synthesis.

An experimental drug in early development for aggressive brain tumors can cross the blood - brain tumor barrier, kill tumor cells and block the growth of tumor blood vessels, according to a study led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James).

With the release and aggressive marketing of the long - acting narcotic OxyContin in 1996, a class of drugs that had largely been reserved for cancer patients was becoming a go - to treatment for conditions such as lower back pain.

A «Trojan horse» treatment for an aggressive form of brain cancer, which involves using tiny nanoparticles of gold to kill tumour cells, has been successfully tested by scientists.

Several studies have supported a role for cancer stem cells in the aggressive brain tumors called glioblastoma, but those studies involved inducing human tumors to grow in mice, and as such their relevance to cancer in humans has been questioned.

«Genetic association with aggressive prostate cancer discovered: Study showed a threefold increase in the risk of aggressive prostate cancer for men with the genetic mutation..»

«We have identified a code of «molecular switches» that control a very aggressive subpopulation of brain cancer cells, so - called glioblastoma stem cells,» says Mario Suvà, MD, PhD, of the MGH Department of Pathology and Center for Cancer Research, co-lead author of the Cell arcancer cells, so - called glioblastoma stem cells,» says Mario Suvà, MD, PhD, of the MGH Department of Pathology and Center for Cancer Research, co-lead author of the Cell arCancer Research, co-lead author of the Cell article.

In most patients, the disease will stay inactive for years, while in others, it will suddenly erupt and turn into an aggressive and life threatening cancer.

«This study forms the basis for future research in patients with breast cancer and offers hope for targeted therapy for patients with aggressive triple - negative inflammatory breast cancer,» said lead researcher Mateusz Opyrchal, M.D., Ph.D., Assistant Professor of Oncology at RPCI.

Depressed men with localized prostate cancer were more likely to be diagnosed with more aggressive prostate cancer, received less effective treatments and survived for shorter times than prostate cancer patients who were not depressed, a UCLA study has found.

PARP inhibitors have shown efficacy for a small group of patients with breast cancer with inherited mutations in BRCA genes, but have failed in the more aggressive triple - negative disease.

Cancer Research UK's hunt for finding early stages of aggressive prostate cancer is notCancer Research UK's hunt for finding early stages of aggressive prostate cancer is notcancer is not over.

Young people with body mass indexes (BMIs) over 30 are more likely to experience aggressive malignancies, says author Nathan A. Berger, MD, Hanna - Payne Professor of Experimental Medicine; director of the Center for Science, Health and Society; member of the Case Comprehensive Cancer Center; and professor of medicine, biochemistry, oncology and genetics at Case Western Reserve University School of Medicine.

«New inhibitor brings new hope for aggressive triple receptor - negative breast cancer.»

«Study identifies potential treatment target for pancreatic cancer: Molecular signature found in 30 percent of PDAC tumors associated with more aggressive cancer.»

«Our data clearly suggests that AKR1B1 overexpression represents an oncogenic event that is responsible for the aggressive behaviors of basal - like breast cancer cells,» Dong explains.

Women with the variant were at much higher risk for cancer, had more recurrences, were often hit with multiple cancers and were more likely to die from aggressive forms of these diseases.

Mi - Prostate Score, or MiPS, was significantly more accurate than PSA alone for predicting cancer as well as predicting aggressive prostate cancer that is likely to grow and spread quickly.

Together with clinical researchers, they are preparing treatments for glioblastoma — the most aggressive brain cancer in adults — , Friedreich's Ataxia — a hereditary neurodegenerative disease — , and a type of paediatric brain cancer.

Few existing treatments offer durable survival benefits for patients whose NSCLC has spread past the lungs, due in part to the aggressive nature of lung cancer and its propensity to progress, even following treatment.

Of the 113 volunteers enrolled in the study, 41 men — or 36 percent — were found to have more aggressive cancer than initially suspected, meaning they were not good candidates for active surveillance.

«The goal is to find specific biomarkers of aggressive cancers,» said Charles Brendler, MD, Co-Director of the John and Carol Walter Center for Urological Health & Program for Personalized Cancer Care at NorthShore and author of the study.

«Aggressive cancers contain regions where the cancer cells are starved for oxygen and die off, yet patients with these tumors generally have the worst outcome.

«For men with prostate cancer, emotional distress may lead to more aggressive treatment.»

Immunotherapy is a promising approach in the treatment of metastatic melanoma, an aggressive and deadly form of skin cancer; but for most patients, immunotherapy drugs so far have failed to live up to their promise and provide little or no benefit.

Women who pursue a more aggressive surgery for early stage breast cancer have nearly eight times the odds of reporting substantial employment disruptions, according to a new study from University of Michigan Comprehensive Cancer Center researcancer have nearly eight times the odds of reporting substantial employment disruptions, according to a new study from University of Michigan Comprehensive Cancer Center researCancer Center researchers.

In the group of patients with aggressive, or high risk, prostate cancer, the average number of days from diagnosis to surgery or radiation treatment was 96 days for Caucasian patients, and 105 days for African American patients.

«This remodeling process of the cell proteome by autophagy is an important immune - suppressive survival mechanism for Ras - driven cancers, and inhibiting autophagy can provide a means to target these aggressive cancers,» notes White, who is also a distinguished professor of molecular biology and biochemistry at Rutgers School of Arts and Sciences.

In the study, researchers found that, as a group, men prescribed testosterone for longer than a year had no overall increase in risk of prostate cancer and, in fact, had their risk of aggressive disease reduced by 50 percent.

The team therefore analyzed the case history of 890 breast cancer patients and found that low Numb - 1 and -2 levels correlated with an increased risk of aggressive, metastatic disease, particularly for the luminal subtype of breast cancers, which tend to retain a normal, functional copy of the p53 gene.

«For example, we found that highly aggressive ovarian cancer cells are glutamine - dependent, and in our laboratory studies, we showed that depriving such cells of external sources of glutamine — as some experimental drugs do — was an effective way to kill late - stage cells.

In the study, the genetic targets were messenger RNA (mRNA) that code for certain proteins known to be biomarkers for aggressive breast cancer cells.

But other types — colon and bladder cancer and certain leukemias, for example — are usually more aggressive and harder to treat.