Sentences with phrase «for aggressive tumors»
Answering important clinical questions — such as whether genetic diversity is a risk factor for aggressive tumor development or how it relates to treatment resistance — requires analyzing samples from many patients with different types of cancer.
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This is especially true for multifocal prostate cancer, less aggressive tumors, and cases of prostatitis or prior prostate irradiation, where MRI alone may not give the correct localization and malignancy grade.»
«This research represents a big step forward in understanding why some tumors are more aggressive than others and being able to predict rationally which neoantigens will be the most effective at stimulating an immune response,» said Dr. Balachandran, a member of the David M. Rubenstein Center for Pancreatic Cancer Research at MSK, and corresponding author of the companion study in Nature.
Many biomarkers are available for estimating tumor mass, but a possibly more important aspect of a tumor's pathology is how aggressive it is and how fast it is growing.
An experimental drug in early development for aggressive brain tumors can cross the blood - brain tumor barrier, kill tumor cells and block the growth of tumor blood vessels, according to a study led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James).
Therefore, researchers are aggressively looking to find new molecular targets for this aggressive brain tumor.
Several studies have supported a role for cancer stem cells in the aggressive brain tumors called glioblastoma, but those studies involved inducing human tumors to grow in mice, and as such their relevance to cancer in humans has been questioned.
«Study identifies potential treatment target for pancreatic cancer: Molecular signature found in 30 percent of PDAC tumors associated with more aggressive cancer.»
The test also predicts risk for having an aggressive tumor, helping doctors and patients make decisions about whether to wait and monitor test levels or pursue immediate biopsy.
«Finding which mechanisms determine why melanoma is so aggressive is very complex because more than 80,000 mutations have been described for this tumor,» says Direna - Alonso Curbelo, the article's first author.
Glioblastoma is the most aggressive type of tumor that originates in the brain and with no curative treatments currently available, the average survival time for patients ranges from 15 to 18 months.
«Aggressive cancers contain regions where the cancer cells are starved for oxygen and die off, yet patients with these tumors generally have the worst outcome.
«Mouse studies hold promise for a simple treatment for an aggressive gastric tumor.»
In a major breakthrough for ovarian and uterine cancers, Yale researchers have defined the genetic landscape of rare, highly aggressive tumors called carcinosarcomas (CSs), pointing the way to possible new treatments.
«Potential pancreatic cancer target challenged: New research finds PDX1 critical for cancer growth, but blocking it may lead to more aggressive tumors.»
Last year, Wittrup showed that delivering antibodies and IL - 2, a signaling molecule that helps to boost immune responses, could halt the growth of aggressive melanoma tumors in mice for as long as the treatment was given.
For years, scientists have observed that tumor cells from certain breast cancer patients with aggressive forms of the disease contained low levels of mitochondrial DNA.
Findings published in Oncotarget offer new hope for children with highly aggressive brain tumors like atypical teratoid / rhabdoid tumor (AT / RT) and medulloblastoma.
Improving the understanding of these genetic changes in these diseases, can point to new directions for diagnosis and treatment, including a way to potentially differentiate aggressive tumors from those that are not life threatening.
As this variant also appears to be associated with the development of more aggressive prostate tumors, a diagnostic test for the variant may enable doctors to make more informed decisions as to how closely they should monitor those who are at high risk, and how aggressively they should treat the disease once it presents.
For a majority of patients diagnosed with aggressive, high - grade tumors with metastases, the five - year survival rate is about 16 percent, though chemotherapy has been associated with an improvement in survival, and new targeted agents are being tested.
Doctors are already using drugs, such as Herceptin, that specifically target malfunctioning genetic pathways in tumors, but no such therapies are currently available for certain aggressive forms of the disease, such as the triple negative subtype.
In the new study, published online March 27, 2018, in Cell Reports, a team led by UCSF's David Raleigh, MD, PhD, found that increased activity of a gene known as FOXM1 appears to be responsible for the aggressive growth and frequent recurrence of these tumors.
These two aspects of tumor progression (hypoxia and reoxygenation) cooperate to provide growth advantages essential for the progressive development of aggressive tumors [21].
In addition to research on rhabdomyosarcoma, the Ignatius laboratory has also generated new syngeneic zebrafish models of aggressive Malignant Nerve Sheath Tumors and hemangiosarcomas for which there are no effective treatments.
In addition, our investigators have used epigenetic biomarkers to: develop screening tests for cancer; help guide surgeons in removing cancerous tumors; predict drug resistance; and, pinpoint more aggressive cancers.
It can make a difference, for example, if community members know that tumors may be more aggressive in certain populations.
The study, led by the SciLifeLab member Marene Landström, might open new possibilities for early detection of aggressive prostate tumors and novel therapeutic strategies.
«This has important implications for tumor development because certain cells might be more aggressive than others,» Beck said.
Many women are «triple negative» No one yet knows precisely why, but African - American women are roughly twice as likely as white women to have triple - negative breast cancer — so called because tumor cells in this particularly aggressive form of the disease test negative for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER - 2).
Chemotherapy may be recommended for patients with more aggressive tumors (e.g. higher grade tumors).
The prognosis for cats with mammary tumors is guarded as mammary tumors tend to be more aggressive and metastatic in cats.
Regrettably, dogs and cats develop a number of benign and cancerous tumors that require aggressive surgery for a cure or to provide long - term control.
The best outcome for your cat is to catch a tumor early and have aggressive surgery performed.