Most multiple myeloma patients, however, are ineligible
for allogeneic transplantation due to age and medical restrictions.
Not exact matches
HSCT is effectively used today as a form of «replacement» therapy
for patients with hard - to - treat blood cancers, providing healthy cells from either the patient (autologous
transplantation) or from a donor (
allogeneic transplantation) to better equip patients to fight the disease on their own.
In the study, analysis of patient samples demonstrated that high LSC17 scores meant poor outcomes with current standard treatment, even
for patients who had undergone
allogeneic stem cell
transplantation.
Collaboration with Hematology and Bone Marrow
Transplantation Unit research group in molecular diagnostics applied to the management of patients undergoing
allogeneic SCT, especially
for the detection of minimal residual disease and early relapse.
As a result, they are currently being investigated as a cellular therapeutic
for the treatment of autoimmune diseases and long - term patient and graft survival following solid organ
transplantation, and
allogeneic hematopoietic stem cell
transplantation.
Mehta J, Gordon LI, Tallman MS, et al., Does younger donor age affect the outcome of reduced - intensity
allogeneic hematopoietic stem cell
transplantation for hematologic malignancies beneficially?
Allogeneic Sibling Donor Peripheral Blood Stem Cells
Transplantation With Myeloablative Conditioning
for Chronic Myeloid Leukemia in Blast Crisis - Successful Treatment Despite Severe Phase of the Disease
In the future, outpatient blood and bone marrow stem cell
transplantation will be offered to a broader group of patients with other blood disorders and
for allogeneic transplants (transplant from non-twin donor stem cells).
Hutter G and Thiel E
Allogeneic transplantation of CCR5 - deficient progenitor cells in a patient with HIV infection: an update after 3 years and the search
for patient no. 2.
Warren D. Shlomchik, M.D. Yale University Memory T cells
for improved immune reconstitution and GVL in
allogeneic hematopoietic stem cell
transplantation
Another possible complication
for patients receiving
allogeneic transplantation is known as graft - versus - host disease (GVHD).
Allogeneic cells, particularly mismatched or haploidentical cells, in the context of hematopoietic
transplantation have been found to provide potent immune surveillance
for both hematologic and solid tumor malignancies in a process referred to as graft - versus - tumor [13]--[15].
These
allogeneic cells have the potential to participate in immune surveillance
for breast or other cancers as observed in clinical hematopoietic stem cell
transplantation.
If these results are confirmed and one or more of these FLT3 - targeted drugs become approved by the FDA, testing
for the FLT3 biomarker may eliminate the need
for thousands of patients to undergo stem cell
transplantation (each
allogeneic transplant costs hundreds of thousands of dollars and place recipients at grave risk of infection and other complications such as Graft vs. Host disease).
By integrating the aforementioned observations of FMc in autoimmunity and
transplantation immunobiology, we reasoned that
allogeneic FMc might provide immune surveillance
for breast cancer in parous women.
Acute myeloid leukemia (AML) is the leading cause of leukemia mortality in the United States.1 Curative treatment involves intensive induction chemotherapy, before proceeding to either consolidation chemotherapy or
allogeneic stem cell
transplantation based on the patient's risk
for relapse.2 This approach has been employed
for > 4 decades and, although most individuals achieve complete remissions with front - line therapy, 3 the majority of patients ultimately relapse with drug - resistant disease, and overall survival rates remain disappointingly poor.4 The limited ability of many patients to tolerate the intense chemotherapy - based treatments, in particular hematological toxicity, further contributes to the poor outcomes noted in this disease.