Sentences with phrase «for altered levels»

The evidence for altered levels of sirtuins to produce benefits large enough to chase is very mixed, despite the occasional study showing marginal or gender - specific outcomes.

Not exact matches

According to The Telegraph, Ohanian said: «Reddit offers the opportunity for us, as humans, to connect on a much deeper, broader level because users have an alter ego and aren't tied to a social network of friends with whom they want to share how perfect their lives are.»

Actual results, including with respect to our targets and prospects, could differ materially due to a number of factors, including the risk that we may not obtain sufficient orders to achieve our targeted revenues; price competition in key markets; the risk that we or our channel partners are not able to develop and expand customer bases and accurately anticipate demand from end customers, which can result in increased inventory and reduced orders as we experience wide fluctuations in supply and demand; the risk that our commercial Lighting Products results will continue to suffer if new issues arise regarding issues related to product quality for this business; the risk that we may experience production difficulties that preclude us from shipping sufficient quantities to meet customer orders or that result in higher production costs and lower margins; our ability to lower costs; the risk that our results will suffer if we are unable to balance fluctuations in customer demand and capacity, including bringing on additional capacity on a timely basis to meet customer demand; the risk that longer manufacturing lead times may cause customers to fulfill their orders with a competitor's products instead; the risk that the economic and political uncertainty caused by the proposed tariffs by the United States on Chinese goods, and any corresponding Chinese tariffs in response, may negatively impact demand for our products; product mix; risks associated with the ramp - up of production of our new products, and our entry into new business channels different from those in which we have historically operated; the risk that customers do not maintain their favorable perception of our brand and products, resulting in lower demand for our products; the risk that our products fail to perform or fail to meet customer requirements or expectations, resulting in significant additional costs, including costs associated with warranty returns or the potential recall of our products; ongoing uncertainty in global economic conditions, infrastructure development or customer demand that could negatively affect product demand, collectability of receivables and other related matters as consumers and businesses may defer purchases or payments, or default on payments; risks resulting from the concentration of our business among few customers, including the risk that customers may reduce or cancel orders or fail to honor purchase commitments; the risk that we are not able to enter into acceptable contractual arrangements with the significant customers of the acquired Infineon RF Power business or otherwise not fully realize anticipated benefits of the transaction; the risk that retail customers may alter promotional pricing, increase promotion of a competitor's products over our products or reduce their inventory levels, all of which could negatively affect product demand; the risk that our investments may experience periods of significant stock price volatility causing us to recognize fair value losses on our investment; the risk posed by managing an increasingly complex supply chain that has the ability to supply a sufficient quantity of raw materials, subsystems and finished products with the required specifications and quality; the risk we may be required to record a significant charge to earnings if our goodwill or amortizable assets become impaired; risks relating to confidential information theft or misuse, including through cyber-attacks or cyber intrusion; our ability to complete development and commercialization of products under development, such as our pipeline of Wolfspeed products, improved LED chips, LED components, and LED lighting products risks related to our multi-year warranty periods for LED lighting products; risks associated with acquisitions, divestitures, joint ventures or investments generally; the rapid development of new technology and competing products that may impair demand or render our products obsolete; the potential lack of customer acceptance for our products; risks associated with ongoing litigation; and other factors discussed in our filings with the Securities and Exchange Commission (SEC), including our report on Form 10 - K for the fiscal year ended June 25, 2017, and subsequent reports filed with the SEC.

Key support levels ahead for the latter index are 1,905, a 3 percent drop from Friday's close, and then 1,820, a violation of which «would alter the longer - term uptrend of the broader market.»

If altered levels of either hormone were to affect the appetite for financial risk, could this in turn destabilize the market as a whole?

The franchisees allege that 3G Capital (RBI's parent company) has failed to maintain franchisee relationships, altered the company's rent and royalty structure (which were to be maintained for 5 years post-acquisition), and caused a drop in employment levels.

Unless there's an event that will materially alter the long - term stream of cash flows that will be delivered by companies to investors for decades to come, what you're actually seeing is a daily dance of surface - level investor psychology that gradually reveals or obscures the latent fundamentals below.

But it would be consistent with his overall approach to say that any changes to the operation of the intellect effected by old age or drunkenness — or, for that matter, altered dopamine levels — ought to be attributed not to the operation of the rational soul itself but to the operation of the composite man.

(CNN)- A Catholic church outside Buffalo, New York is taking prayers for the jobless to a new level, inviting unemployed parishioners to place their resumes on the alter

We are not embarrassed and indignant enough to scrutinize and alter policies responsible for such levels of poverty and inequality.

Things I adapted include the cooking level and time for the glaze, using butter instead of margarine, and baking in two loaf pans instead of a tube pan, which of course altered the baking time.

«For instance, we have developed flavor compounds that can effectively mask the off - notes that functional ingredients such as vitamins and minerals contribute to the flavor profile, or that can alter the perception of traits such as sweetness or cooling levels,» Callahan notes.

i do think the voting process for where to host the tourneys can be altered, so that there are specific monies that must be given unto governments at local levels rather than just a pile of money to the central government to be absorbed by pocket after pocket all the way down the chain with nothing to show for it other than a bunch of new cars in the pocketed ones driveways (or whatever).

It didn't change how I saw myself professionally, but it did alter my social life and my friendships: It's not that I loved my friends any less, but I couldn't maintain that level of daily commitment to them if I was also going to make room for my boyfriend.

Supplements of vitamin C for a mother do not significantly alter the amounts in breastmilk, as they remain fairly constant no matter what mother's intake levels (assuming the mother is not vitamin - C deficient).

The colours act as a reminder for you to cool or heat the room, to modify the baby's clothing, to use a different tog Grobag Baby Sleep Bag or for non-sleep bag users to alter the level of bedding.

Unhealthy fats can alter the fat composition of your milk and put your baby at risk for developing high blood pressure and increased cholesterol levels down the road.

In animal models, exposure to cigarette smoke or nicotine during fetal development alters the expression of the nicotinic acetylcholine receptor in areas of the brainstem important for autonomic function, 28 alters the neuronal excitability of neurons in the nucleus tractus solitarius (a brainstem region important for sensory integration), 29 and alters fetal autonomic activity and medullary neurotransmitter receptors.30 In human infants, there are strong associations between nicotinic acetylcholine receptor and serotonin receptors in the brainstem during development.31 Prenatal exposure to tobacco smoke attenuates recovery from hypoxia in preterm infants, 32 decreases heart rate variability in preterm33 and term34 infants, and abolishes the normal relationship between heart rate and gestational age at birth.33 Moreover, infants of smoking mothers exhibit impaired arousal patterns to trigeminal stimulation in proportion to urinary cotinine levels.35 It is important to note also that prenatal exposure to tobacco smoke alters the normal programming of cardiovascular reflexes such that there is a greater - than - expected increase in blood pressure and heart rate in response to breathing 4 % carbon dioxide or a 60 ° head - up tilt.36 These changes in autonomic function, arousal, and cardiovascular reflexes might all increase an infant's vulnerability to SIDS.

Elections are run at the state level, so a state - gerrymandered election could alter that balance of power in the state legislature, which would effect things like voter - suppression measures, enactment and enforcement of campaign finance regulations, and the ability of elections to be monitored and for rules to be enforced by non-partisan (or partisan) entities.

Volunteers who handled receipts containing the hormone - altering compound bisphenol A for two hours showed elevated BPA levels in their urine.

For example, it is possible to tune the fiber mechanics by altering the level of crosslinking within and between the fibers.»

Those studied by Dunlop are her colleagues alter their traits — protein expression, for instance — but not their genomes, making them significantly more difficult to identify since the resistance level of each bacterium changes over time.

Some may stem directly from how the altered digestive system works — secreting different levels of hormones, for example — or changes in nerve cells that communicate with the gut.

«When cells are stressed, for example when nutrient levels are low, they alter protein production as a survival strategy.

«We found that more dynamically altering the water levels in wetland units at the refuge improves habitat for migratory birds,» said Rosenberg.

Altered sphingolipid levels in blood have been associated with depression and have been proposed as a therapeutic target for major depressive disorder.

The study team, led by Joan C. Han, M.D., a former NICHD investigator now at the University of Tennessee Health Science Center, first analyzed the BDNF gene for naturally occurring genetic changes that alter levels of BDNF production.

A strategic focus is to continue to develop computational tools (such as KinomeXplorer, NetworKIN, and NetPhorest) and to deploy these on genome - scale quantitative data obtained by, for example, mass spectrometry, genomic, and phenotypic screens to understand the principles of how spatio and temporal assembly of mammalian signaling networks transmit and process information at a systems level in order to alter cell behavior.

However, the team was able to show that so - called tight junction proteins, which are known to be important for the blood - brain barrier permeability, did undergo structural changes and had altered levels of expression in the absence of bacteria.

«It was surprising to see all these significant changes in A1C and body weight without altering medications or activity level and without aiming for weight reduction,» Dr. Hamdy pointed out, «Which tells us that nutrition therapy can be as effective as medications even after a long duration of the disease.»

For instance, this device can help us understand the mechanisms by which various inputs and treatments alter plant growth at the cellular level.

Variants that increase the chance of obesity or high blood pressure, for example, appear to boost CHD risk more strongly than variants that alter insulin or glucose levels.

Foods designed to have novel compounds or altered levels of natural substances require a special attention for unintended health effects, the committee concluded.

And although Earth has seen CO2 levels much higher in the remote past, the human species has not — and our penchant for burning may continue to alter the climate that has allowed our civilization to flourish.

Similar mRNA and protein levels, but altered conformations, were found for wild - type and polymorphic P - gp.

«If circumstances change due to global warming that alter the level of risk, insurance companies need to be free to reflect that risk,» says David Snyder, vice president and assistant general counsel for the American Insurance Association (AIA).

Likewise, certain brain regions of these optogenetically stimulated, post-stroke mice showed increased levels of proteins associated with heightened ability of nerve cells to alter their structural features in response to experience — for example, practice and learning.

Using samples from the Dominantly Inherited Alzheimer Network (DIAN) study, the researchers found that people who carried the mutation responsible for this form of Alzheimer's also had altered levels of specific lipids in their blood plasma compared to the control group.

Another question is for the noise - forcing mechanism, whether the high frequency forcing will change or whether the state at which the ocean becomes sensitive to such forcing will be altered (eg «charging» at a different rate or reaching «charged level» at a different threshold).

If, for instance, a researcher finds that dozens of genes in a microarray are differentially expressed on a high - fat purified ingredient diet compared to a low - fat GB diet, it is tempting to conclude that gene expression was altered due to the differences in fat levels between the diets.

Fish exposed to higher carbon dioxide levels — which are expected to increase in the oceans for several decades — showed impaired cognitive function, learning difficulties, slowed visual capacity and altered sense of smell and sound.

Using gene therapy to alter levels of specific proteins in a targeted fashion is an intermediary advance in medicine for age - related conditions.

In the meantime, all that extra stored heat will cause seawater to expand, raising sea levels, and altering the ecosystems that marine plants and animals have adapted to for eons.

Further, there is evidence to suggest that AGEs produce raised levels of chronic inflammation by altering cellular behavior through the receptor for AGEs, RAGE.

For patients with iTTR 70 % or greater, the level of INR variability did not alter event rates.

The results indicate that, if CERs are accepted as eligible units of compliance under CORSIA without any restrictions, the demand for offset credits from international aviation to 2035 is unlikely to either materially impact the current price level for CERs or alter the overall level of greenhouse gas abatement undertaken.

Battles for the soul have been fought while either tapering steadily off the mind - altering medications and working consciously with the debilitating withdrawal symptoms, or without the added burden of the medications, simply working to bring balance on a deeper soul level in order to engage more fully in life as a balanced and constructively engaging human being.

For example, fluorides can cause zinc deficiency which in turn can cause damage to your brain by altering your manganese levels.

This crossover alters the chemical structure of the second drug, creating potential for you to reach a toxic dose very quickly or, conversely, never reach an effective level, Tims explains.

I would be shocked to see somebody with hair loss that had a healthy scalp pH so adding (quality) lactobacillus probiotics to your diet along with healing a leaky gut (many resources on the internet tell you how to do that) will not only alter skin pH to a healthy level but stop the chronic inflammation which, as is so rightly mentioned in this article, the catalyst for every disease / condition which we develop.