Sentences with phrase «for apolipoprotein»

Preclinical evidence of Alzheimer's disease in persons homozygous for the e4 allele for apolipoprotein E. NEJM 1996; 334 (12): 752 - 758.

The two most striking risk factors appear to be hyperinsulinism and possession of one or two E4 alleles for the apolipoprotein E gene (ApoE4), which is involved in lipid processing.

ApoE stands for Apolipoprotein E, which is a protein that transports fats and cholesterol in the body.

Until recently, only four genes associated with late - onset Alzheimer's have been confirmed, with the gene for apolipoprotein E-e4, APOE - e4, having the largest effect on risk.

He was also missing the Alzheimer's susceptibility allele apo, a well - established variant of a gene for apolipoprotein E carried by approximately two out of three patients.

Carrying a particular version of the gene for apolipoprotein E (APOE) is the major known genetic risk factor for the sporadic, late - onset form of Alzheimer's disease, but exactly how that variant confers increased risk has been controversial among researchers.

Not exact matches

After finishing the survey, participants in the study can opt for an additional study and consider submitting DNA collected by a cheek swab to be tested for variants at the Apolipoprotein E (APOE) gene.

Individuals were classified as high risk for Alzheimer's if a DNA test identified the presence of a genetic marker — having one or both of the apolipoprotein E-epsilon 4 allele (APOE - e4 allele) on chromosome 19 — which increases the risk of developing the disease.

(Apolipoprotein E-ε4 is the top risk gene for Alzheimer's.)

A large - scale genetic analysis in PSP patients, however, identified a common tau sequence that increases by 5.5 times a person's chances of developing the disease, making this variant a stronger risk factor for PSP than one copy of the apolipoprotein E-ε4 variant is for Alzheimer's.

They also tracked Apolipoprotein E (APOE 4), a well - known genetic risk factor for Alzheimer's, as well as lifetime cumulative exposure to unhealthy levels of PM2.5 — particles which are at least 30 times smaller than the diameter of a human hair and frequently cause the haze over urban areas.

The gene in question, apolipoprotein E (apoE), codes for a protein in the brain's astrocyte cells that seems to help spur nerve cell growth and clear up debris from neuronal injuries brought by head trauma, stroke, or cerebral hemorrhage.

For decades, scientists have known that people with two copies of a gene called apolipoprotein E4 (ApoE4) are much more likely to have Alzheimer's disease at age 65 than the rest of the population.

Together, they looked at two well - known genetic risk factors for CKD in black people, the mutated G1 or G2 variations in the gene known as apolipoprotein L1 (APOL1).

Carriers of the apolipoprotein (ApoE) ɛ4 allele are at greater risk for developing late - onset Alzheimer's disease (AD), develop AD at an earlier age, and experience a more severe cognitive decline and shorter survival times.

Two studies published in the Journal of Alzheimer's Disease indicate that some of the pathologic changes associated with Alzheimer's disease in older individuals are not apparent in young people who carry the apolipoprotein (APOE) genetic risk factor for developing the disease.

Humans carry a gene for a protein in cells called apolipoprotein E, which helps clear amyloid - beta from the brain by binding to it and breaking it down.

Until recently, only one gene variant, Apolipoprotein E-e4 (APOE - e4), had been confirmed as a significant risk factor gene for the common form of late - onset Alzheimer's disease, which typically occurs after age 60.

Dr. Huang studies the origin and development of Alzheimer's disease, focusing on the pathological role of apolipoprotein E4 (apoE4)-- the major genetic risk factor for Alzheimer's.

Nox2 modification of LDL is essential for optimal apolipoprotein B - mediated control of agr type III Staphylococcus aureus quorum - sensing.

Other genes relevant for regulating blood cholesterol levels are well - expressed in enhanced hiPS - HEP cells, e.g., apolipoprotein B (a VLDL), apolipoprotein A1 (an HDL), PCSK9, sterol regulatory element - binding proteins 1 and 2 (SREBP - 1 and -2), and lipoprotein lipase (LPL), which hydrolyzes triglycerides in lipoproteins into free fatty acids and glycerol.

DONG ET AL.The allele apolipoprotein E ε4 (APOE ε4) is the greatest genetic risk factor for Alzheimer's disease (AD), but the role of the ApoE4 protein in AD has long been elusive.

Dr. Mahley, along with Gladstone Investigator Yadong Huang, MD, PhD, will use the funding to identify new chemical compounds that can target apolipoprotein E4 (apoE4)-- the strongest genetic risk factor for developing Alzheimer's.

The editors of JLR will pay close attention to the Spotlight Talks, as the journal is just wrapping up an eight - review series on the major risk factor for Alzheimer's disease, apolipoprotein E, and it's time to get inspired for the next one.

A specific type of brain activity important for memory replay is disrupted in mice with the E4 version of the apolipoprotein E (apoE4) gene, which may interfere with memory formation.

The aim of this study was to investigate the role of serotonin in depression, searching for association of two serotoninergic polymorphisms (T102C of serotonin receptor 5 - HT2A and serotonin transporter linked polymorphic region -5-HTTLPR - of SLC6A4 gene) with depressive symptoms and considering their possible interactions with Apolipoprotein E... (ApoE) and between themselves, in a sample of 208 sporadic AD patients and 116 normal controls from Italy.

The aim of this study was to investigate the role of serotonin in depression, searching for association of two serotoninergic polymorphisms (T102C of serotonin receptor 5 - HT2A and serotonin transporter linked polymorphic region -5-HTTLPR - of SLC6A4 gene) with depressive symptoms and considering their possible interactions with Apolipoprotein E

were used to examine the potential association between VRF scores and the change in MMSE and CDR - SB scores, adjusting for age, sex, and the apolipoprotein ɛ 4 allele (APOE4).

Background Apolipoprotein E (APOE) is the most statistically significant genetic risk factor for late - onset Alzheimer disease (LOAD).

The relations between fat from cheese and apo (a), between fat from ice cream and the insulin sensitivity index, and between fat from butter and BMI, HDL cholesterol, LDL - HDL ratio, and apolipoprotein A-I also remained significant after adjustment for physical activity.

At apolipoprotein A-V (APOA5), carriers of rare non-synonymous mutations were at 2.2-fold increased risk for MI.

In 60 801 patients with coronary heart disease and 123 504 controls, OR for myocardial infarction was 0 · 96 (0 · 94 - 0 · 98; p < 0 · 0001) per 1 - SD increment in apolipoprotein (a) protein isoform size in serum due to rs2457564, which was directionally concordant with the OR observed in PROMIS for a similar change.

Methods: In this mendelian randomisation study, we measured lipoprotein (a) concentration and determined apolipoprotein (a) isoform size with a genetic method (kringle IV type 2 [KIV2] repeats in the LPA gene) and a serum - based electrophoretic assay in patients and controls (frequency matched for age and sex) from the Pakistan Risk of Myocardial Infarction Study (PROMIS).

Hypertriglyceridemia is an independent risk factor for cardiovascular disease, and plasma triglycerides (TGs) correlate strongly with plasma apolipoprotein C - III (ApoC - III) levels.

For instance, APOC3 knockouts had absent plasma apolipoprotein C - III.

The main component of HDL, apolipoprotein A-I (apo A-I), is largely responsible for reverse cholesterol transport.

Saturated fat has also been shown to elicit minimal effects on apolipoprotein B, a risk factor for cardiovascular disease, relative to carbohydrates (Mensink, Zock, Kester, & Katan, 2003).

Apo E genes influence heart disease risk providing instruction for making a protein called apolipoprotein E.

Consumption of fructose - sweetened beverages for 10 weeks increases postprandial triacylglycerol and apolipoprotein - B concentrations in overweight and obese women.

Berberine also lowers apolipoprotein B by 13 - 15 %, which is a big risk factor for cardiovascular disease (22, 23).

Apolipoprotein B (ApoB) levels may be the most comprehensive metric for determining one's susceptibility to all manner of heart health complications.

There are even more cholesterol markers that can be run nowadays, for example oxidized cholesterol and apolipoprotein studies.

Review: apolipoprotein E ε4 allele is a risk factor for Alzheimer's disease in different ethnic groups