Sentences with phrase «for axonal»

Here, we investigate the hypothesis that miR - 181a regulates the molecular pathways that control mDA axonal growth, and provide evidence that miR - 181a inhibition may be a novel therapeutic approach for axonal regeneration in PD.

We report that targeting miR - 181a regulates axonal growth, and that miR - 181a inhibition may be a novel therapeutic approach for axonal regeneration of neurons affected by PD.

His research will attempt to identify novel ligands to utilize for axonal regeneration as well as identifying their molecular mechanisms.

Surreptitiously, a novel neuroprotective strategy for axonal injury, such as traumatic brain injury, has emerged from these studies, which is currently under development.

Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mice.

Tau helps provide structure to brain cells, is a marker for axonal damage — and is also what McKee finds spotted throughout the brains she examines in her Boston U. lab.

Not exact matches

«Laminins function as attractive chemical cues for haptotaxis of axonal growth cones,» explains NAIST Prof. Naoyuki Inagaki, whose lab studies how forces are generated in the cellular microenvironment to create directed axonal migration.

One of the most encouraging finding is that PSR - 1 plays an early role in the axonal fusion process required for neuroregeneration, said Xue.

«Given the effectiveness of inosine in promoting cortical plasticity, axonal sprouting, and dendritic branching, the present evidence of efficacy after cortical injury in a non-human primate, combined with a long history of safe use, indicates a need for clinical trials with inosine after cortical injury and spinal cord injury,» noted Dr. Moore.

Using their own recently - developed genetic labeling techniques for tracking these cells in early development in mice, Taniguchi and his team observed that, like most neurons, the cells remodeled their axonal organization through development.

«Now we know the signals for fear and pleasure can be transmitted by different axonal projections, new targeted treatments might be envisioned,» he says.

In conclusion, our findings suggest that microstimulation, with its anatomical precision, physiologic - level currents, and action via axonal projections, holds promise for modification of memory circuits and thus for the treatment of memory impairments in people suffering from neurological disorders.

This retrograde axonal transport of NGF is absolutely essential for the survival of the innervating neurons.

GS showed genome - wide significant slope decrease by — 3.86 (95 % CI: — 4.64 to — 3.07, p < 2 × 10 — 16) per standard deviation of the GS for 6 SNPs mapping to genes involved in neuronal development and signaling, axonal myelinization, and glutamatergic / GABA neurotransmission.

In my laboratory, we hypothesize that age - dependent neuronal death occurs partly in response to the decline with age, of the process of axonal transport of those critical proteins that are needed for neuronal survival.

The latter is particularly important for the establishment of long axonal projections, which requires coordinated long - range organelle transport.

This was then subjected to initial testing for immunological efficacy in mThy1 - AS mice, which overexpress WT human AS under the murine Thy1 promoter, and which exhibit sensorimotor behavioral deficits, axonal AS pathology, and C - terminally - truncated AS aggregates with regional distribution similar to PD and PD dementia (PDD).

The labelling is for acetylated tubulin in red (identifying all axons), and green for the cell permeable dye calcein, which is only applied on the axonal side of the chambers (top half) and allows the identification of those neuronal cell bodies (bottom half) that have extended axons to the other side of the microfluidic device.

Failure of myelin to compensate for larger axonal diameters suggested a lack of plasticity during the processes of myelination and radial axonal growth.

Brad Fortune, OD, PhD Devers Eye Institute, Portland, OR The Dr. Miriam Yelsky Memorial Research Grant Project: Axonal Transport of Mitochondria: Developing an In Vivo Imaging Assay for Glaucoma Research

This suggests that understanding the role of dysregulated miRNA in mDA neurons may provide insights into the pathophysiological mechanisms of mDA axonal degeneration in PD, and provide new opportunities for mDA axonal protection or re-growth.

Therefore understanding the dysfunctional molecular pathways that cause mDA axonal degeneration, and targeting these to protect or re-grow mDA axons, may be a promising therapeutic approach for PD.

A) Proteins that associated with axonal guidance and signaling were significantly enriched (p = 6 × 10 − 20) in the CSF proteomes for all pooled samples.

i) The insured person is accepted for admission, on an in - patient basis, to a public hospital named in a Guideline with positive findings on a computerized axial tomography scan, a magnetic resonance imaging or any other medically recognized brain diagnostic technology indicating intracranial pathology that is a result of the accident, including, but not limited to intracranial contusions or haemorrhages, diffuse axonal injury, cerebral edema, midline shift or phneumocephaly.