Sentences with phrase «for brain atrophy»

Homocysteine is a risk factor for brain atrophy, cognitive impairment and dementia.

Not exact matches

The researchers detected this SMN long noncoding RNA, or lnc - RNA (pronounced «link RNA») for short, in human embryonic kidney cells, brain cell samples and neurons derived from the stem cells of healthy people and those with spinal muscular atrophy type I and II.

Furthermore, brain imaging data for these very elderly animals shows a slight loss of grey matter (neuronal cell bodies), an effect that the researchers have not yet explained, as well as significantly slowed atrophy of white matter (the neuronal fibers connecting different areas of the brain).

Atrophy of the hippocampus, the area of the brain responsible for thinking and memory, is an early sign of Alzheimer's disease.

«Atrophy of the hippocampus, a region of the brain crucial for memory, is a common feature of AD, although it may also be detected in asymptomatic individuals as well as healthy adult carriers of the ApoE ɛ4 allele,» explained Andy Simmons, PhD, of the Department of Neuroimaging of the Institute of Psychiatry of King's College London.

«A healthy lifestyle, such as participating in lifestyle physical activity, is beneficial for brain health, and may help lessen gray matter atrophy (decreases).»

SVD features and brain tissue atrophy both increase with age, are often present together, and are risk factors for stroke and dementia.

Namely, they investigated language and cognition control areas in the frontal regions of the brain, and medial temporal lobe structures that are important for memory and are brain areas known to atrophy in MCI and AD patients.

Will those part of our brain atrophy, shriveling to useless raisins and unable to do the work related to memory capabilities we take for granted?

Age was strongly associated with rate of brain atrophy (r = 0.32, P < 0.01) and so all subsequent analyses were adjusted for age.

Treatment with B vitamins for 24 months significantly slowed the rate of brain atrophy.

Salsalate successfully reversed these effects in a mouse model of FTD, lowering tau levels in the brain, rescuing memory impairments, and protecting against atrophy of the hippocampus — a brain region essential for memory formation that is impacted by dementia.

Objective: The primary objective of the present study was to estimate how large a sample size would be needed for future clinical trials for AD - modifying treatments in Japan using atrophy measures of the brain as a surrogate biomarker.

Abstract: Background: Little is known about the sample sizes required for clinical trials of Alzheimer's disease (AD)- modifying treatments using atrophy measures from serial brain magnetic resonance imaging (MRI) in the Japanese population.

Last year Ionis had a massive success with an ASO for another brain disease called spinal muscular atrophy (SMA).

Background: Little is known about the sample sizes required for clinical trials of Alzheimer's disease (AD)- modifying treatments using atrophy measures from serial brain magnetic resonance imaging (MRI) in the Japanese population.

Abbreviations: Aβ, amyloid β - peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; Ambra1, activating molecule in Beclin -1-regulated autophagy; AMPK, AMP - activated protein kinase; APP, amyloid precursor protein; AR, androgen receptor; Atg, autophagy - related; AV, autophagic vacuole; Bcl, B - cell lymphoma; BH3, Bcl - 2 homology 3; CaMKKβ, Ca2 + - dependent protein kinase kinase β; CHMP2B, charged multivesicular body protein 2B; CMA, chaperone - mediated autophagy; 2 ′ 5 ′ ddA, 2 ′, 5 ′ - dideoxyadenosine; deptor, DEP - domain containing mTOR - interacting protein; DRPLA, dentatorubral pallidoluysian atrophy; 4E - BP1, translation initiation factor 4E - binding protein - 1; Epac, exchange protein directly activated by cAMP; ER, endoplasmic reticulum; ERK1 / 2, extracellular - signal - regulated kinase 1/2; ESCRT, endosomal sorting complex required for transport; FAD, familial AD; FDA, U.S. Food and Drug Administration; FIP200, focal adhesion kinase family - interacting protein of 200 kDa; FoxO3, forkhead box O3; FTD, frontotemporal dementia; FTD3, FTD linked to chromosome 3; GAP, GTPase - activating protein; GR, guanidine retinoid; GSK3, glycogen synthase kinase 3; HD, Huntington's disease; hiPSC, human induced pluripotent stem cell; hVps, mammalian vacuolar protein sorting homologue; IKK, inhibitor of nuclear factor κB kinase; IMPase, inositol monophosphatase; IP3R, Ins (1,4,5) P3 receptor; I1R, imidazoline - 1 receptor; JNK1, c - Jun N - terminal kinase 1; LC3, light chain 3; LD, Lafora disease; L - NAME, NG - nitro - L - arginine methyl ester; LRRK2, leucine - rich repeat kinase 2; MIPS, myo - inositol -1-phosphate synthase; mLST8, mammalian lethal with SEC13 protein 8; MND, motor neuron disease; mTOR, mammalian target of rapamycin; mTORC, mTOR complex; MVB, multivesicular body; NAC, N - acetylcysteine; NBR1, neighbour of BRCA1 gene 1; NOS, nitric oxide synthase; p70S6K, ribosomal protein S6 kinase - 1; PD, Parkinson's disease; PDK1, phosphoinositide - dependent kinase 1; PE, phosphatidylethanolamine; PI3K, phosphoinositide 3 - kinase; PI3KC1a, class Ia PI3K; PI3KC3, class III PI3K; PI3KK, PI3K - related protein kinase; PINK1, PTEN - induced kinase 1; PKA, protein kinase A; PLC, phospholipase C; polyQ, polyglutamine; PS, presenilin; PTEN, phosphatase and tensin homologue deleted from chromosome 10; Rag, Ras - related GTP - binding protein; raptor, regulatory - associated protein of mTOR; Rheb, Ras homologue enriched in brain; rictor, rapamycin - insensitive companion of mTOR; SBMA, spinobulbar muscular atrophy; SCA, spinocerebellar ataxia; SLC, solute carrier; SMER, small - molecule enhancer of rapamycin; SMIR, small - molecule inhibitor of rapamycin; SNARE, N - ethylmaleimide - sensitive factor - attachment protein receptor; SOD1, copper / zinc superoxide dismutase 1; TFEB, transcription factor EB; TOR, target of rapamycin; TSC, tuberous sclerosis complex; ULK1, UNC -51-like kinase 1; UVRAG, UV irradiation resistance - associated gene; VAMP, vesicle - associated membrane protein; v - ATPase, vacuolar H + - ATPase; Vps, vacuolar protein sorting

For starters, you don't want to eat too little because this causes your body to panic releasing stress hormones, atrophying your lean muscle mass... which causes more hormone imbalances... which destroys your sleep... which cause massive issues with your brain... and down the nasty rabbit hole you go.

The trade - off: decreased growth hormone and IGF - 1 increase longevity Finding safe and effective ways to increase growth hormone and IGF - 1 naturally, thereby, improving muscle and brain function while simultaneously preventing their atrophy seems like a no - brainer, who doesn't want to be more fit and smarter — for longer?

The age - related decline in growth hormone and associated IGF - 1 has been linked to age - related muscle atrophy, increased adipose tissue, and neuronal dysfunction.2, 9 In fact, growth hormone replacement therapy in elderly men has been shown to increase lean body mass.9 Growth hormone therapy (1 mg / day — for 5 months) has also been used to improve cognitive function in healthy adults and adults with mild cognitive impairment.10 While only modest amounts of growth hormone cross the blood - brain barrier, IGF - 1, which is actually responsible for the cognitive benefits, gets across just fine.