Not exact matches
Although the newest edition of the authoritative textbook, Vitamin D, claims that in humans
calcidiol binds with equal affinity to the DBP whether it is derived from vitamin D2 or vitamin D3, 37 the citation
for this statement is the author's own PhD thesis, in which he reported results obtained from testing the DBP of a mere two people.48 Since the gene
for the DBP is one of the most polymorphic known (meaning it exists in many forms), existing in three common alleles and 124 known rarer alleles (alleles are specific forms of the same gene), each allele itself having many polymorphisms, 37 a sample size of two is rather unconvincing.
In the early 1970s, Swedish researchers showed vitamin D3 to have a substantially higher affinity
for human DBP than vitamin D2.49 Their sample size was not reported and probably very small, and they unfortunately could not test the
calcidiol forms of these vitamins because 25 - hydroxyvitamin D3 was at that time not yet commercially available.
The research cited above, moreover, suggests that vitamin D would be stored in adipose tissue at these levels and released when
calcidiol levels drop, as they would during the winter in temperate climates — an added bonus
for those who wish to obtain their vitamin D from foods like cod liver oil and fatty fish rather than from supplements during the winter.
1 On his Vitamin D Council web site, Cannell now recommends blood levels of
calcidiol between 50 and 80 ng / mL53 and supplementation of 1,000 IU
for every 25 pounds of bodyweight.2 For someone weighing between 150 and 175 pounds, he thus recommends between 6,000 and 7,000 IU per day from all sourc
for every 25 pounds of bodyweight.2
For someone weighing between 150 and 175 pounds, he thus recommends between 6,000 and 7,000 IU per day from all sourc
For someone weighing between 150 and 175 pounds, he thus recommends between 6,000 and 7,000 IU per day from all sources.
It's all
calcidiol, ready
for storage in fat tissue or dispersal to the kidneys
for conversion into calcitriol, also known as 1,25 (OH) D. Calcitriol is the active hormonal form whose primary role is to regulate blood calcium levels.
The project Dr. Young and the University of Missouri team are working on investigates the use of
calcidiol, a vitamin D metabolite, to safely and rapidly improve vitamin D status in dogs, with the goal of determining the potential
for use of
calcidiol as an adjunct treatment
for various forms of canine cancer.