Sentences with phrase «for cell behavior»

Because DNA is encoded with the instructions for cell behavior, damaged DNA can alter cell processes including those that regulate growth and division.

As new examples of beneficial noise come to light, scientists are working to better understand the implications for cell behavior, evolution and human health.

Not exact matches

While we should hesitate to pass an anachronistic judgment on his behavior, we can at least restrain the celebrations of his fiancée, Maria von Wedemeyer, as his true love, the heroine for the perfect hero — celebrations that were inspired by the publication of their correspondence in Love Letters from Cell 92.

Other researchers have tried changing cell behavior by creating protein switches from scratch, but Lim's approach — mixing and matching naturally existing proteins — may be more versatile and practical: «It can be useful as a biotechnology device or for repairing cells in humans.

Next, Anderson and his colleagues used a set of genetic tools to identify exactly which neurons were responsible for the effect on aggression and to see if the gene that encodes for Tk also controls aggressive behavior by acting in that cell.

This handful of brain cells is known as the dorsomedial prefrontal cortex, or dmPFC, and it sits in a region integral for learning appropriate social behavior.

In cancer cells, the protein networks that control the behavior are changed in such a way as to cause the cells to lose control and break away — a mutated skin cell, for instance, might then migrate into the bloodstream.

Tissue engineering provides a more practical means for researchers to study cell behavior, such as cancer cell resistance to therapy, and test new drugs or combinations of drugs to treat many diseases.

Dr. Massagué is particularly interested in the ability of tumor cells to hug blood vessels, as he suspects this behavior may be essential for the survival of metastatic cancer cells not only in the brain but also in other parts of the body where metastatic tumor growth can occur.

For their research, Pekosz and his team, using human nasal tract cells, studied the weakened strain of the flu virus that is used in the nasal spray vaccine and compared its behavior with that of the flu virus itself.

While displaying this behavior, the bonded platinum nanoparticles maintain an effective surface area functioning as a catalyst for chemical reactions, a discovery that could lower the production costs of platinum - catalyzed fuel cells.

«Our data clearly suggests that AKR1B1 overexpression represents an oncogenic event that is responsible for the aggressive behaviors of basal - like breast cancer cells,» Dong explains.

Support for this scenario was unexpectedly found in humans, where expression of Crhbp and Pmch are extremely closely linked in the hypothalamus, indicating they may actually be present in the same cells and together act downstream of Lef1 to regulate behavior.

For the subset of more recent patients, the researchers assessed tumor cell behavior — in particular, cancer cells» ability to cross the endothelium (inner layer) of blood vessels.

Results suggest that cells grown in the device exhibit more natural behaviors than when grown in traditional culturing methods, and the filtration by the glomerulus is necessary for healthy cell function.

The researchers also discovered an essential role for the mechanical properties, i.e. the physical stiffness, of the gel in regulating intestinal stem cell behavior, shedding light on how cells are able to sense, process and respond to physical stimuli.

As a factor becomes more concentrated in a cell, it will begin to activate genes that it has less intrinsic affinity for, potentially changing the cell's behavior.

Using juvenile and adolescent mice, Jeffrey Edwards and colleagues investigated the effects of tetrahydrocannabinol (THC), the chemical in marijuana responsible for its effects on cognition and behavior, on VTA GABA cells, an understudied inhibitory cell type in the reward system that regulates dopamine levels.

Cells in a developing embryo have different shapes and behaviors and can be densely packed, making it difficult for a computer to identify and track individual cCells in a developing embryo have different shapes and behaviors and can be densely packed, making it difficult for a computer to identify and track individual cellscells.

Scientists think that these niches control stem cell behavior, that is «telling» the stem cell when to produce more stem cells or when to produce daughter cells that will be the workhorses for that tissue or organ.

For another, although the unusual T cell behavior was entirely absent in kids who didn't get autoantibodies later on, it was recorded in only about half who did.

«This year's Nobel Laureates have been studying this fundamental problem and solved the mystery of how an inner clock in most of our cells in our bodies can anticipate daily fluctuations between night and day to optimize our behavior and physiology... since the paradigm shifting discoveries by Hall, Rosbash and Young, circadian biology has developed into a highly dynamic research field with vast implications for our health and well - being.»

Understanding how networks of cells in circuits work together to give rise to behaviors, thoughts, and emotions requires new technology, he said, and optogenetics is starting to provide new approaches for mapping and repairing the brain.

A strategic focus is to continue to develop computational tools (such as KinomeXplorer, NetworKIN, and NetPhorest) and to deploy these on genome - scale quantitative data obtained by, for example, mass spectrometry, genomic, and phenotypic screens to understand the principles of how spatio and temporal assembly of mammalian signaling networks transmit and process information at a systems level in order to alter cell behavior.

Analyzing large numbers of cells, each with slight differences in their DNA, for their ability to carry out a behavior or survive a drug treatment can reveal the importance of particular genes, or sections of genes, in those abilities.

By themselves, leader cells do not need VEGF for invasive behavior, but VEGF appears to be important for pack formation because it is a mobility factor leaders provide followers.

Though this information - maximizing theory has been tested in a few types of behavior, Sharpee and others believe it could provide a basis for a larger, unified framework for understanding different types of behavior across species, cells, neurons and even larger scale phenomenon, such as resource allocation.

In stressed rats, neurons in the dorsomedial striatum, an area associated with goal - directed behavior (for example, pressing a lever to get a specific treat), had shrunk, making fewer connections to other cells.

The study, «Modulating Behavior in C.elegans Using Electroshock and Antiepileptic Drugs,» just published in PLOS One, has led the researchers to build on the current animal models for inducing seizures via electroconvulsion in the genetically modifiable C.elegans that only has 302 brain cells called neurons.

«These origami can be customized for use in everything from studying cell behavior to creating templates for the nanofabrication of electronic components,» says Dr. Thom LaBean, an associate professor of materials science and engineering at NC State and senior author of a paper describing the work.

And when the cocaine was taken away for a while, these rats were more likely to relapse to addictive behavior if they had started out with the epigenetic tag that kept their cells from reading the D2 gene.

The Penn team did a random targeting of cells, activating neuronal firing with a transgene designed for this purpose, to see which cells are important in the rest / active behavior.

Those data were then combined with information about functional changes in cell behavior to develop a nanomechanical profile, or phenotype, for specific cellular states.

For research purposes, these cells hold an important advantage over those from blood in that they can be cultured without the use of artificial stimulants, which can alter the cells» behavior.

They found that cells in the pars intercerebralis (PI) are essential for rhythmic behavior, and PI cells are connected to the clock cells through a circuit of at least two synapses.

He also envisions that this kind of nanomechanical phenotyping should allow for the development of predictive models for cellular behavior for any kind of cell.

The fact that his obsession with his cell phone was almost typical behavior for his generation had essentially masked his disorder.

When cells were inhibited, the mouse no longer pressed the lever, demonstrating that the activity of these cells was necessary for the mouse to carry out the behavior.

It may, for example, partly account for the differences in brain structure and behavior between identical twins, and could even affect thought processes by subtly influencing the changes in nerve cell connections that occur with experience.

The vectors also contained DNA bar codes, sequences that the researchers could look for later to determine which small RNAs were having a big effect on a cell's behavior.

The rescue of memories, which changed both the structure of neurons as well as the behavior of mice, was achieved using optogenetics, a method for manipulating genetically tagged cells with precise bursts of light.

Researchers from Melbourne's Walter and Eliza Hall Institute have discovered how a common parasite hijacks host cells and stockpiles food so it can lie dormant for decades, possibly changing its host's behavior or personality in the process.

However, efforts to examine the in vitro behavior of tumor cells with endothelial cells from different anatomical regions have been prohibited because, in large part, of the limited number of organ - derived endothelial cell lines available for study.

This insight into cell behavior could help researchers better understand cell jamming and unjamming, which could lead to potential treatments for conditions such as developmental abnormalities, asthma, and cancer.

Amongst others, Dr. Sonntag's work has contributed to developing a cell therapy for Parkinson's disease (PD), and to understanding a role of dysregulated gene and miRNA expression networks in PD and schizophrenia, or dopaminergic and adrenergic receptors in hedonic and impulsive behavior.

The goal is to not only provide broadly applicable experimental tools but also help transform the way in which we think about single cells, cell - cell interactions, diseased cellular states and therapeutics so as to create a new paradigm for understanding and designing systems - level cellular behaviors in multicellular organisms.

«Since cholesterol is required by neurons to form synapses (connections) with other cells, this decrease in cholesterol could affect how nerves function for appetite regulation, behavior, memory and even pain and motor activity,» says Dr. Kahn, who is also Mary K. Iacocca Professor of Medicine at Harvard Medical School.

For example, intra-strain cooperative behaviors are more likely to be evolutionarily stable when different cell lineages are segregated in space, with typical interaction distances between cells being strongly influenced by the diffusivity of secreted products, biofilm architecture, and environmental flow conditions [16 — 19].

The first genetically encoded optical tool that can precisely control brain cells (neurons) by the millisecond, optogenetics allows for light - induced control of neuronal activity, helping researchers understand how neurons form circuits that control behavior.

Respect, trust, and the management of sickle cell disease pain in hospital: comparative analysis of concern - raising behaviors, preliminary model, and agenda for international collaborative research to inform practice.