Sentences with phrase «for cell cycle»

Samples were prepared for cell cycle analysis and immunoblotting.

They speculate that because the process of reprogramming increases the number of cell divisions that take place (as compared to what happens in adult skin cells), there are more opportunities for the cell cycle checkpoints to correct for the chromosomal breakage.

The research team at Mainz University speculates that whilst entanglements between chromosomes need to be removed for cell cycle progression those within a chromosome may not affect function and transmission of genetic information.

Once freed, the proteasome degrades proteins required for cell cycle progression, thus driving cells into senescence.

Hypermethylation of DNA is a key epigenetic mechanism for the silencing of many genes, including those for cell cycle regulation, receptors, DNA repair, and apoptosis (5, 6, 7, 8).

This approach could also be used in many different contexts, not only for cell cycle analysis,» adds Prof. Dr. Dr. Fabian Theis, head of the ICB.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

One particularly interesting use of cell phones for fundraising in the 2008 election cycle: the John Edwards campaign contacted list members via text, urged them to call a number and listen to a recorded message, then connected them to operators to take donations right away.

Ding's team took cells called fibroblasts from the connective tissues of mouse fetuses and bathed them in a cocktail of the four polyarginine - tagged proteins for 12 hours, then they removed the reprogramming proteins for 36 hours, and repeated this cycle four times over.

This brings the fatty acid cycle to a grinding halt, and the parasite can not divide for want of new cell membranes.

Initial results already show stable charge - discharge cycling for as long as 200 hours, which is long enough for use in some industrial or military applications, but not nearly adequate for batteries used in laptops or cell phones.

Surprisingly, the cancer - promoting program that RB - loss unleashed was distinct from the cell - cycle control genes that RB is best known for controlling.

By copying the gene for Spo0F (purple) early in the cell - division cycle and the gene for KinA (green) later in the cycle, the bacteria assure that the decision to form a spore or divide is made when DNA replication has completed.

But in addition to these factors, Hunt, who won a share of the 2001 Nobel Prize in physiology or medicine (along with Leland Hartwell and Paul Nurse) for his discovery of cyclin, a key regulator of the cell cycle, emphasizes early independence and playfulness.

Afyon used this vanadate - borate glass powder for the battery cathodes, which he then placed in prototypes for coin cell batteries to undergo numerous charge / discharge cycles.

The cells are crucial for arousal during sleep - wake cycles and are thought to play a key role in narcolepsy.

Dr. Alicia Melendez, a biologist at Queens College, City University of New York (CUNY), and her colleagues report in Current Biology that autophagy is important for the proliferation of stem cells, specifically for promoting the cell cycle of stem cell progenitors.

In contrast, cells with a dilute electrolyte solution could only last for 6 cycles.

The Krebs cycle in the mitochondria of cells is used to supply both energy and building materials for cell growth.

CDKs are crucial for the regulation of the cell cycle.

The budding yeast, Saccharomyces cerevisiae, is a prime organism for studying fundamental cellular processes, with the functions of many proteins important in the cell cycle and signaling networks found in human biology having first been discovered in yeast.

The studies on autophagy by Yoshinori Ohsumi, which earned him the Nobel Prize in Medicine in 2016, and the discovery of cell cycle regulatory genes for which Leland Hartwell, Timothy Hunt and Paul Nurse received the same award in 2001, including the research of Elizabeth Blackburn, Carol Greider and Jack Szostak on telomeres, telomerase and its protective effect on the chromosomes, were all made possible thanks to yeast.

He began to show immediate improvement and after three cycles of treatment received a blood stem cell transplant, and since has been cancer free for 19 months.

For the proliferation and differentiation to occur, B cells must cycle between the two zones.

Besides providing greater power density than current batteries, the new cells must also last for 10 years and 4,000 operating cycles.

For example, genes in the CDK family regulate the cell cycle and are commonly mutated or deleted in many cancers.

The research, published in the journal Cell Cycle, has important implications for future cancer prevention and treatment.

Researchers at the University of Edinburgh and the MRC Laboratory for Molecular Biology in Cambridge used molecular analysis to find that concentrations of magnesium rose and fell in a 24 - hour cycle in all cell types, and that this impacts on the cells» internal clocks.

And, when the scientists selectively activated or removed just six PI cells positive for DH44, the fly's activity cycles became irregular.

Fly CRF, called DH44, is required for rest / activity cycles and is produced in cells that receive input from the clock cells in the fly brain.

Recharging one of these primary cells could allow the battery to be reused, but the possible number of recharging cycles for such a cell is very limited — it performs more poorly with each recharge.

Telomeres are essential for chromosome stability, but their functions at specific cell - cycle stages are unknown.

A human vaccine against malaria has faltered in the face of the sophisticated life cycle of Plasmodium falciparum, the one - celled parasite responsible for the most severe form of the disease.

The predicted hosts for the Klosneuviruses are protists (single - celled eukaryotic (nucleus - containing) microorganisms) and while their direct impacts on protists are not yet worked out, these giant viruses are thought to have a large impact on these protists that help regulate the planet's biogeochemical cycles.

The longest glowing cells belonged to night owls; lark skin cells glowed for shorter times, revealing a faster cycle.

Cell biologist Harold Varmus, for example, compares scientific research to cycling, his favorite sport: «Long flat intervals.

Investigators at Dartmouth have extensive Shared Resources available for research and this team used the Pathology Shared Resource to evaluate cell cycle distribution in the glioma.

They inhibit viral infection by preventing viral entry into target cells and by blocking different stages of the viral replicative cycle for different viruses.

In 2001 he was jointly awarded the Nobel Prize for Physiology or Medicine for discoveries of key regulators of the cell cycle.

«The CDK4 and 6 proteins are critical drivers of the cell - division cycle and are required for the formation and growth of various types of solid tumors,» says Dana - Farber's Shom Goel, MD, PhD, co-first author of the study with Molly DeCristo of the Hematology Division at BWH.

These experiments were essential to understanding the effect of gemcitabine on cell cycle and the effective scheduling of checkpoint inhibitor for maximal malignant cell kill.

The researchers had noticed, for instance, that the length of individual stages in the cell cycle varied from cell to cell, while the length of the overall cycle was much more consistent.

How the vital processes of cell cycle control (with the final event of cytokinesis) and signalling for cell wall biosynthesis are exactly coordinated remains to be determined.

c - Rel is essential for B lymphocyte survival and cell cycle progression.

Stat5 Is required for IL -2-induced cell cycle progression of peripheral T cells.

LA JOLLA, CA — A team of scientists at the Salk Institute for Biological Studies has identified why disruption of a vital pathway in cell cycle control leads to the proliferation of cancer cells.

Hsiou - Chi Liou and colleagues find that c - Rel, a lymphoid - specific member of the NF - kappaB / Rel family of transcriptional factors, is essential for B lymphocyte survival and cell cycle progression, [i] and that it is important for inducible cytokine and cytokine receptor expression and a key regulator of early activation and proliferation in T cells.

In this new study, licensing refers to origin licensing, the process of helicase loading onto DNA for genome duplication purposes during the G1 phase of the cell cycle.

«We suspect that faults in cell - cycle regulation account for a variety of developmental brain diseases.»

Drosophila Ctf4 is essential for efficient DNA replication and normal cell cycle progression.