Sentences with phrase «for cell expansion»

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There were signs that a ramp - up was happening, such as solar cell manufacturer Panasonic opening new jobs for product expansion, as well as our report on a Tesla patent featuring an adhesive that can conduct electricity through the solar tiles.

The senator gathered with area residents Friday to protest what he called the poster child for the unwarranted expansion of the cell phone industry outside -LSB-...]

Perhaps, Clavería says, cell expansion driven by Myc sets the stage for a tumor.

Meanwhile, recent human studies indicate that aging is associated with an increase in somatic mutations in the hematopoietic system, which gives rise to blood cells; these mutations provide a competitive growth advantage to the mutant hematopoietic cells, allowing for their clonal expansion — a process that has been shown to be associated with a greater incidence of atherosclerosis, though specifically how remains unclear.

«Too little FAM134B leads to an uncontrolled dilation and expansion of this organelle, which is harmful for the cell,» explains Ivan Dikic.

One of the primary causes of the decline in Grauer's gorilla numbers has been the expansion in artisanal mining for coltan (a key mineral used in the manufacture of cell phones and other electronics) and other minerals in the gorilla's range.

Gerton hypothesized that cancer cells, which are highly proliferative and might need more than the usual amount of ribosomes, would select for expansion of copy number.

The molecules — YAP (Yes - associated protein) and TAZ (PDZ - binding motif)-- are critical regulators of downstream genes and proteins that are important for the expansion and specification of myelin - forming Schwann cells.

Rho - kinase inhibitor Y - 27632 (ROCKi) is a potential drug molecule, which has been reported to support the gene expressions typical for the chondrocytes, thus restricting their phenotypic conversion to fibroblastic cells upon the cellular expansion.

For many microbes, the expansion of growing cell groups toward a source of limiting nutrients tends to promote the spontaneous segregation of different strains due to genetic drift along the advancing group front [36].

«A few weeks after they are born,» says Dr. Enikolopov, «the pituitary undergoes massive expansion» that suggests a role for adult stem cells.

By combining SNP - targeting allele - specific silencing and gain - of - function approaches, we showed that a 46 - glutamine expansion in human HTT was sufficient for a dominant - negative effect on spindle orientation and changes in the distribution within the spindle pole and the cell cortex of dynein, p150Glued and NuMA in neural cells.

Using a novel technique to genetically modify T cells for adoptive transfer, Carl June, Michael Kalos, David Porter, Bruce Levine, and colleagues at the University of Pennsylvania School of Medicine achieve clinical responses in patients with chronic lymphocytic leukemia, including two complete, durable (one year) clinical responses, accompanied by in vivo expansion and long - term functional persistence of gene - modified cells.

First, the MimEX ™ Cell Plating Procedure is used to maintain a uniform irradiated fibroblast monolayer for the rapid clonal expansion and efficient differentiation of tissue - specific adult epithelial stem cells.

For the expansion and differentiation of human keratinocyte stem cells for permanent skin restoration in victims of extensive burFor the expansion and differentiation of human keratinocyte stem cells for permanent skin restoration in victims of extensive burfor permanent skin restoration in victims of extensive burns.

MimEX ™ Tissue Models System provides a platform for the isolation, expansion, and differentiation of adult epithelial stem cells into 3 - D ex vivo organ tissue.

The discovery of human oRGs» self - renewing niche and remarkable generative capacity reinforces the idea that these cells may have been responsible for the expansion of the cerebral cortex in our primate ancestors, the researchers said.

Using Cultrex ® BME, MimEX ™ Tissue Models System provides a platform for the isolation, expansion, and differentiation of adult epithelial stem cells into 3 - D ex vivo organ tissue.

In his spare - time, Riggs promotes the expansion of the Student Society for Stem Cell Research (SSSCR).

Although these platforms can be used successfully for small - scale expansion of hMSCs, other platforms will be required to generate the quantity of cells required to support the increasing number of clinical trials utilizing hMSCs and the subsequent large - scale production.

Low - serum conditions for expansion culture of multiple cell types.

The cell produces nerve cells that help form the neocortex — the site of higher cognitive function — and likely accounts for the dramatic expansion of the region in the lineages that lead to man, the researchers say.

Cost - effective creation of biofunctionalised scaffolds, tailored to function as stem cell niches for expansion, transport and delivery.

The DEF - CS system is a robust culture system for efficient expansion of human induced pluripotent stem (iPS) cells in a feeder - free and defined environment.

Regina Duryagina (Bornhäuser, TUD)-- «Role of Jagged - 1 and extracellular matrix components for the maintenance of hematopoietic stem and progenitor cells during ex-vivo expansion» (2013)

Dissertation work led to phenotypic validation of a novel gene for the scale - up and expansion of stem cells.

Essential role for Survivin in the proliferative expansion of progenitor and mature B cells.

Promoting survival and proliferation at the single - cell level is critical for expansion of any clonal colonies containing the mutation of interest generated by the gene editing process.

We offer defined and xeno - free laminin cell culture matrices for reliable expansion of pluripotent cell and differentiation and maintenance of specialized cell types

Thus, the increased pathology seen in immunization - enhanced HLH is associated with expansion of CD8 T cells specific to the peptide used for immunization.

For instance, during emergency care, allogeneic therapy is usually the only relevant option due to the time constraints of autologous cell expansion.

Our present studies are focusing on the molecular interactions which prevent excessive T cell death after the initial period of clonal expansion and which are essential for promoting late T cell division and providing long - term survival signals.

The portfolio includes U.S. and foreign patents and applications directed to culture, expansion and scale - up of pluripotent stem cells and cell types derived therefrom, various differentiation processes for production of mesendoderm, definitive endoderm, PEC - 01, and endocrine precursors, as well as claims directed to the Company's Encaptra ® macro-encapsulation device platform.

For more information, check out our recent webinar with Dr. Suzan Imren on her work with Drs. Colleen Delaney and Guy Sauvageau on ex vivo culture and expansion of normal and leukemic hematopoietic cells.

Expansion of CD34 + cells normalized relative to the values obtained in SFEM medium (dark gray bar) after culturing purified CD34 + cord blood cells for 7 days in StemSpan ™ serum -[SFEM, SFEM II (gold bar)-RSB- and animal component - free ACF (orange bar) media, and six media from other suppliers (light gray bars).

The order severely restricts embryonic stem cell research to existing lines of cells and bans federal funding for any research expansion outside his directive.

Requested cell lines are tested by PCR analysis for mycoplasma spp. and Murine Parvoviruses (MPV) upon completion of expansion and prior to shipment.

Here we controlled for some of the features that differed among the earlier studies, and analyzed both the survival and expansion of naive CD4 + T cells transferred into MHC syngeneic, allogeneic, or MHC negative environments.

For example, a recent study showed that PKCθ was crucial for the expansion of alloreactive T cells, and inhibition of PKCθ could reduce GVHD while preserving the GVL effect (5For example, a recent study showed that PKCθ was crucial for the expansion of alloreactive T cells, and inhibition of PKCθ could reduce GVHD while preserving the GVL effect (5for the expansion of alloreactive T cells, and inhibition of PKCθ could reduce GVHD while preserving the GVL effect (54).

After creating a stem cell model of the disease from patients» skin cells, the Scripps Research scientists found strong evidence for the involvement of a DNA repair enzyme in the FXN triplet repeat expansion.

Memory CD4 + T cells, whose survival and expansion showed no requirements for MHC molecules at all, dampened the space - induced expansion of naive cells, showing that the two populations are not independent in their requirements for peripheral niches.

Due to the large number of hES cells and human induced Pluripotent Stem (hiPS) cells needed by I - Stem's research groups, the development of large - scale culture systems for expansion and differentiation of those cells is critical.

Therefore, proliferation of the F958V - positive cells in the presence of the JAK inhibitor CMP6 is not completely abolished and allows further expansion and proliferation of these cells in the presence of the JAK inhibitor CMP6 for days or even weeks (Online Supplementary Figure S4A).

Beyond the expansion of the collection of barcoded cell lines for testing larger panels of compounds, next steps will include determining whether PRISM can be used to study the complex interactions between different cell types found within tumors, or to study tumor evolution during cancer development or after cancer treatment.

Rational Bioprocess Design for Human Pluripotent Stem Cell Expansion and Endoderm Differentiation Based on Cellular Dynamics.

In addition, we wish to characterize how variations in neural stem cells behavior may account for the large expansion of the human brain, but also how alterations may lead to pathological brain development.

Zonari E, Desantis G, Petrillo C, Boccalatte FE, Lidonnici MR, Kajaste - Rudnitski A, Aiuti A, Ferrari G, Naldini L, Gentner B. Efficient ex vivo engineering and expansion of highly purified human hematopoietic stem and progenitor cell populations for gene therapy.

Here, authors from Corning Life Sciences describe dissolvable microcarriers as a scalable solution for large - scale expansion and harvest of functional human mesenchymal stem cells by enabling simplified downstream processing and high - yield cell recovery.

This is because tumor - derived and immortalized cells are often karyotypically abnormal and may diverge physiologically from normal cells in various respects, whereas primary cells have limited capacity for expansion.

We subsequently used a novel Design of Experiments approach to finely tune the optimal memory B cell expansion and differentiation conditions for human memory B cell subsets.