Sentences with phrase «for cell fate»

Among them, there are genetic instability (mainly aneuploidy, a defect in chromosome number), defects in the symmetry of cell division (important for cell fate specification and tissue architecture) and impaired ciliogenesis.

In addition, it provides a marker for cell fates and insight into the molecular and cellular mechanisms by which FSC progeny diverge into distinct fates.

Not exact matches

A research group at the University of Basel now describes for the first time a mechanism by which hippocampal neural stem cells regulate their own cell fate via the protein Drosha.

The team lead by Prof. Verdon Taylor was able to demonstrate for the first time a cell - intrinsic mechanism regulating stem cell fate.

The findings — published today in Nature — provide significant insights into cell types fated to relapse and can help accelerate the quest for new, upfront therapies, says Dr. Dick, a Senior Scientist at Princess Margaret Cancer Centre, University Health Network, and Professor in the Department of Molecular Genetics, University of Toronto.

This is what makes the matter particularly exciting for the scientists, because «this control centre decides about the fate of differentiating cells and thus about the fate of the root architecture.»

It will be relatively easy for the team to monitor the fate of the new cells because they can be seen in the eye through a microscope.

The search for answers might shed light on how cells» fates become fixed during development, and how plants manage to retain such flexibility.

This is interesting because it implies that all the instructive mechanisms [for these cells» fate] are present in the adult brain.»

Cas is required for polar and stalk cell fate specification, while Eya is a negative regulator of these cells» fate.

Because the precise activation of Hox genes is essential for a cell's fate, «the research should prove extremely useful in developing novel embryonic stem cell - based therapies, Mazzoni adds.

For the researchers, says Mathis, another important conclusion can be drawn: «If you want to understand the behaviour and fate of microbial populations, it's sometimes necessary to analyse every single cell.»

For about a decade, researchers have been able to direct the fate of stem cells by tuning the stiffness of its microenvironment.

In some cases, the jump altered gene expression in a way that influenced the stem cells» fate — making them more likely to turn into neurons, for example.

COURTESY SHENDURE AND SCHIER LABS CRISPR FOR FATE - MAPPING Researcher: Jay Shendure, Professor, Department of Genome Sciences, University of Washington Project: In collaboration with Alexander Schier's lab at Harvard University, Shendure's group came up with a new way to trace cell lineages in cell culture and in whole organisms — in this case, developing zebrafish.

The pathway that it takes decides in which valley it will finally settle, providing a metaphor for the acquisition of a specific cell fate.

These results suggest the fate of pluripotent cells may be purposely altered to generate multipotent retinal progenitor cells, which differentiate into functional retinal cell classes and form a neural circuitry sufficient for vision.

Cell therapy, as envisaged by the teams of I - Stem, is primarily based on the identification of experimental protocols that can specifically guide differentiation of pluripotent cells to a cell fate, which presents a interest for the replacement of the defective cell population from the patient (the striatal neurons for Huntington's disease, the cells of the retinal pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, etCell therapy, as envisaged by the teams of I - Stem, is primarily based on the identification of experimental protocols that can specifically guide differentiation of pluripotent cells to a cell fate, which presents a interest for the replacement of the defective cell population from the patient (the striatal neurons for Huntington's disease, the cells of the retinal pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, etcell fate, which presents a interest for the replacement of the defective cell population from the patient (the striatal neurons for Huntington's disease, the cells of the retinal pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, etcell population from the patient (the striatal neurons for Huntington's disease, the cells of the retinal pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, etc.).

A two - step process appears to regulate cell fate decisions for many types of developing cells, according to researchers from the University of Chicago.

This demonstrates that even though the anterior neural plate is essential for proper eye morphogenesis, cultured pluripotent cells were not directed to a retinal fate — even when grafted directly into the eye field.

Researchers have discovered a gene in zebrafish so powerful it can be used to redirect the fate of cells in the developing embryo to become beating heart cells, suggesting that a similar gene in humans could be used to generate heart cells in culture for transplant in ailing people.

Perivascular cells, including pericytes in the smallest blood vessels (e.g., microvessels) and ARCs around larger ones, express mesenchymal stem cell markers and bear a multi-differentiation fate potential (differentiate into osteoblasts, chondrocytes, adipocytes, smooth muscle cells and myocytes) similar to that documented for MSCs in vitro.

Goessling and North were post-doctoral fellows in the laboratory of co-author Leonard Zon, MD, a stem cell researcher at CHB and a scientific founder of Fate Therapeutics, when they hit upon 16,16 - dimethyl PGE2 while looking for compounds that could regulate the production of hematopoietic stem cells.

We have developed a technology for visualizing the behavior of DNA molecules within living cells, and elucidated the intracellular fate of DNA introduced from the outside.

Found that muscle - specific histone methyltransferases and microRNAs regulate the activity of Hand2, a transcription factor essential for ventricle formation and more recently showed that microRNAs can efficiently guide stem cell fate decisions.

Critical issues include: (i) heterogeneity in stem cell populations (ii) regulation of cell fate choices; (iii) declining tissue performance with age and exposure to environmental injuries; (iv) the use of iPS and Embryonic Stem (ES) cells, and reprogramming methods for phenotyping disease states and potential use of these stem cells in the clinic.

Dr Véronique Azuara has worked for several years in the field of developmental biology and genetics moving from lymphocyte development (PhD training at the Pasteur Institute — Paris) to epigenetic studies (post-doctoral training at the MRC / Clinical Sciences Centre — London) to explore how chromatin shut down contributes to lineage restriction and maintenance of cell fate identity through development.

The question of how cellular behavior is controlled is at the center of stem cell biology, and understanding the mechanisms of cell fate regulation is key for treating diseases that occur upon dysregulation, such as cancer or diabetes.

In doing so, specific cell types may activate immune responses to fine tune cell - fate decisions at the organismal level; for instance, DNA damage in germ cells induces an innate immune response in worms that promotes endurance of somatic tissues to allow delay of progeny production when germ cells are hit by DNA damage.

He is internationally recognized for his work on the control of cell growth and fate by the TGF -(beta) family of growth factors.

The latest findings reported by researchers at La Jolla Institute for Allergy and Immunology illustrate just how important TET proteins are in controlling cell proliferation and cell fate.

In a paper published in Nature Genetics, an interdisciplinary research team of scientists from the Centre for Genomic Regulation (CRG)-- including a Centro Nacional de Análisis Genómico (CNAG - CRG) group — in Barcelona, Spain, shows that the three - dimensional organisation of the genome plays a key role in gene expression and consequently in determining cell fate.

Overall, this study highlights the close links between transcription factor - driven genome topology dynamics, chromatin state, and gene expression and highlights a critical role for genome topology in enforcing transcriptional programs and cell fate.

His group defined a functional niche for B cells (around sinusoids in the bone marrow), identified the first two mutants that abrogate marginal zone B lymphocyte development, developed the concept of a follicular versus marginal zone B lymphoid cell - fate decision, and discovered two new defined stages of peripheral B cell development, the marginal zone precursor (MZP) B cell, and the Follicular type II B cell.

Demonstrated that not a single «master» transcription factor, but rather a combination of factors, are important for reprogramming of cell fate from one somatic lineage back to a pluripotent state.

The advent of human induced pluripotent stem cells has been heralded as a major breakthrough in the study of pluripotent stem cells, for these cells have yielded fundamental insights into the reprogrammability of somatic cell fates, but also because of their seemingly great promise in applications, including potential uses in cell therapy.

Next, we identified genes whose expression was associated with Th1 or Tfh fates, and demonstrated a T - cell intrinsic role for Galectin - 1 in supporting a Th1 differentiation.

When BMP turns ES cells into muscle it activates a protein called Smad1, a DNA - binding protein that, in opposition to Nanog, switches on genes responsible for muscle cell fate.

In a statement, Paul Grayson, president and CEO of Fate Therapeutics, said: «Dr. Jaenisch's prescient vision in 2003 for creating human iPS [cells], and how reprogrammed cells could be used to revolutionize drug discovery and enable cell - based therapies, is truly unparalleled.»

Differentiation into extraembryonic endoderm [21] or neural progenitors [33] are frequent early outcomes of spontaneous differentiation when human ES cells are cultured in the presence of a feeder cell layer, and it is interesting to speculate that the cells are being primed for these fates.

These workers considered that this fluctuation might account for reversible lineage priming towards specific cell fates.

Suzuki, possibly inspired by his new job as a research scientist at the Research Unit for Organ Regeneration in Kobe, Japan, explains it this way: «Just as humans can start over in life, differentiated cells can also take on other fates following the generation of undifferentiated stem cells.»

These miRKO models provide a tool for understanding how noncoding RNAs contribute to the specification of cell fate and function, and how deregulation of these RNAs may contribute to human disease.

The new, US patent credits the Whitehead Institute's Rudolf Jaenisch, a scientific founder with Fate Therapeutics who licensed the technology to the company, and his former postdoc Konrad Hochedlinger, now at the Massachusetts General Hospital, with inventing a method for reprogramming cells

These cells can produce platelets and red blood cells, and a full understanding of their in vivo derivation and fate decision choices represent critical areas for our understanding of normal blood development and processes underlying cancer.

We are studying the mechanisms that maintain multipotent cell fate during quiescence (reversible cell cycle arrest) using C. elegans as a model for aging stem cells.

A final note on the fate of amino acids - once absorbed, amino acids can be used directly by cells for the synthesis of new enzymes or new cell structures, for the building of structural proteins (such as actin and myosin in the muscles), for the synthesis of OTHER amino acids (via transamination), or used for energy.

Eschewing the trappings of the biopic — psychology, cult of the hero — Assayas catches Carlos (Edgar Ramirez) mid-stream, between the fated year 1973 (Four Concepts of Psychoanalysis, coup in Chile), when Waddie Haddad (Ahmad Kaabour) makes him number two in the European network of the Popular Front for the Liberation of Palestine (PFLP); and 1994, when he is snatched in a Khartoum hospital by the French Secret Services who promptly brought him to stand trial in Paris: no cute or sinister growing - up tales, no face - to - face with oneself within the four walls of a cell.

[1 star] Flatliners (09.29 / 09.29 / 09.29) Geostorm (10.23 / 10.20 / 10.20) Pirates of the Caribbean: Salazar's Revenge (aka Dead Men Tell No Tales)(05.18 / 05.26 / 05.25) Justice League (11.16 / 11.17 / 11.17) A Cure for Wellness (02.20 / 02.17 / 02.24) Annabelle: Creation (08.01 / 08.11 / 08.11) Home Again (09.05 / 09.08 / 09.29) King Arthur: Legend of the Sword (05.17 / 05.12 / 05.19) Monster Trucks (12.18.16 / 01.13 / 12.16.16) The Mummy (06.13 / 06.09 / 06.09) Life (03.24 / 03.24 / 03.24) Dig Two Graves (03.23 / 03.24 / TBA) xXx: The Return of Xander Cage (01.19 / 01.20 / 01.19) War on Everyone (09.06.16 / 02.03 / 10.07.16) A Bad Moms Christmas (11.01 / 11.01 / 11.01) Una (10.08.16 / TBA / 09.01) Fast & Furious 8 (aka The Fate of the Furious)(04.10 / 04.14 / 04.12) Valerian and the City of a Thousand Planets (08.02 / 07.21 / 08.02) The Vault (09.05 / 09.01 / 09.08) Wish Upon (07.12 / 07.14 / 07.28) Fifty Shades Darker (02.10 / 02.10 / 02.10) Wakefield (05.25 / 05.19 / direct to VOD) The Hitman's Bodyguard (08.17 / 08.18 / 08.17) Overdrive (08.11 / direct to VOD / 08.11) Hounds of Love (07.27 / 05.12 / 07.28) The Book of Henry (06.29 / 06.16 / 06.23) Brawl in Cell Block 99 (10.10 / 10.06 / 10.20) The Unseen (12.14 / TBA / 12.15)

OPENING THIS WEEK Kam's Kapsules: Weekly Previews That Make Choosing a Film Fun by Kam Williams For movies opening January 4, 2008 BIG BUDGET FILMS One Missed Call (PG - 13 for mature themes, frightening images, terror, intense violence and some sexual material) Shannyn Sossamon stars in this remake of Chakushin Ari, a high attrition - rate horror flick from Japan about a traumatized young woman who's afraid to answer her cell phone after several of her ill - fated friends receive messages accurately predicting exactly when and how they are about to dFor movies opening January 4, 2008 BIG BUDGET FILMS One Missed Call (PG - 13 for mature themes, frightening images, terror, intense violence and some sexual material) Shannyn Sossamon stars in this remake of Chakushin Ari, a high attrition - rate horror flick from Japan about a traumatized young woman who's afraid to answer her cell phone after several of her ill - fated friends receive messages accurately predicting exactly when and how they are about to dfor mature themes, frightening images, terror, intense violence and some sexual material) Shannyn Sossamon stars in this remake of Chakushin Ari, a high attrition - rate horror flick from Japan about a traumatized young woman who's afraid to answer her cell phone after several of her ill - fated friends receive messages accurately predicting exactly when and how they are about to die.