Sentences with phrase «for cell migration»

After eGFP - expressing CD4 + T cells and WT counterparts were treated with vehicle and indicated inhibitors, respectively, they were mixed with the collagen gel and monitored for cell migration.

Kruppel - like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion

«These findings demonstrate that efficient actin filament disassembly by GMF is essential for rapid dynamics of cell protrusions, and that this dynamics are important for cell migration in a three - dimensional tissue environment,» says Minna Poukkula from the research group of professor Pekka Lappalainen.

They are associated with the cell cytoskeleton — a complex network of interlinking filaments inside the cell that is necessary for cell migration — making them viable targets for inhibiting migration.

EMT is important for cell migration and invasion — two characteristic of metastatic cancer cells — strongly suggesting that the link between lncRNAs and EMT contributes to the metastatic progression of ovarian cancer.

Not exact matches

Additionally, Belly Belly shared a baby's brain is extremely vulnerable to stress because cells are still moving where they need to be (migration) for the first year of life.

In the article, Dr. Margot Sunderland, author of the best - selling book What Every Parent Needs To Know, stated that leaving a child in a state of distress for a prolonged period without offering comfort affects them on a cellular level, specifically the «migration» of their cells as they get to where they need to be.

When those cells were placed on a standard wound assay (for measuring properties like cell migration and proliferation), they moved unusually fast.

The scientists hope their findings on cell migration in zebrafish will open up new perspectives for research on proteins that control metastasis and thus the malignancy of cancer.

Adding two blood - borne proteins associated with cancer cell migration increases the predictive ability of the current biomarker for pancreatic cancer to detect early stage disease, a research team from The University of Texas MD Anderson Cancer Center reports in the Journal of the National Cancer Institute.

Changes in the cells» migration might account for many physical traits linked to tameness in domesticated animals.

In a new study, NAIST scientists, in collaboration with researchers at the Osaka National Hospital and University of Tokyo, report that the L1 Cell Adhesion Molecule (L1 - CAM) is crucial for directed axon migration.

This analysis, done on separate samples from the same patient, revealed that many of the affected genes confer advantages to cancer cells by, for example, enhancing cell migration or resistance to chemotherapy.

As a result, reduced abilities for cell growth, migration and invasion were found.

SUSHI also visualizes synaptic clefts for the first time in slices of live tissue and reveals glia - neuron interactions and cell migration.

«Discovery of a mechanism for determining the direction of collective cell migration.»

Recently published in the journal eLife and featured in a poster session at this year's American Association for Cancer Research (AACR) annual meeting, preclinical experiments show for the first time that PLK1 promotes the migration of prostate cancer cells by setting in motion a process that induces what is known as the epithelial - to - mesenchymal transition (EMT).

«The first thing that needs to happen for wound healing is to activate the migration of epithelial cells,» Oudhoff says.

Previously the only known role for Tie in fruit flies was in long - range signaling in border cell migration.

The coordinated assembly and disassembly of actin in the cell cortex, which lies just beneath the plasma membrane, generates cortical actin waves that are crucial for important cell functions including migration and cell polarity.

When in the light zone, B cells are selected by follicular helper T (TFH) cells for migration to the dark zone.

A study by Sofia J. Araújo, a Ramón y Cajal researcher with the Morphogenesis in Drosophila lab at the Institute for Research in Biomedicine (IRB), elucidates the genetic regulation of cell migration.

Kees Weijer of the University of Dundee in Scotland, who studies the migration of cells in chick embryos and slime mold, has been waiting for a light sheet microscope since the EMBL group first publicized its advances.

During embryonic development individual cells and cell clusters can move over relatively long distances, and cell migration is also essential for wound healing and many immunological processes in adult animals.

Cell migration is important for development and physiology of multicellular organisms.

The team explains that this is a step forward for research into cell migration mechanisms and that future applications will emerge as further investigation and studies are conducted.

A team of researchers at the Massachusetts General Hospital and Harvard Medical School in Boston has developed technologies for precision measurement of cell migration speed before and applied the new tool to study the variations of migration speed in population of cancer cells.

Microfluidic tools for precision measurements of cell migration speed reveal that migratory speed of individual cells changes stochastically from parent cells to their descendants, while the average speed of the cell population remains constant through successive generations.

In order to find the genes that guide that migration, geneticist Ruth Lehmann of the Howard Hughes Medical Institute at New York University Medical School and her colleagues used chemicals to cause mutations in thousands of adult fruit flies then screened their embryonic offspring for lost or misguided germ cells.

In their study, scientists around Prof. Olivier Pertz from the Department of Biomedicine at the University of Basel gained novel insights into the regulation of directional cell migration: Using a special procedure, 20 micrometer wide lines were fabricated on glass thereby mimicking the connective tissue environment — creating a highway for cells.

In addition, cells were stimulated with a growth factor (PDGF) which led to fast cell migration in only one direction lasting for many hours.

Key molecular functions for cell - to - cell communication and cell migration are immediately impaired.

A region of the gene that produces the PACAP38 protein has held nearly constant, even in humans, presumably because the protein plays diverse roles in neuron communication and is essential for normal development of the cerebellum, affecting brain cell migration, for example.

In particular, the research identified several genes regulated by methylation in the egg that are involved in cell adhesion and migration — both vital properties for cells of the developing placenta in establishing connections with maternal tissues to support embryo development.

The small GTPase Rac is a key factor known to be involved in phagocytosis and cell migration in mammals and has been shown to be essential for hemocyte migration within the embryo [29], [30].

The expression of the proprotein convertase furin is strongly associated with increased metastasis (migration) of cancer cells; this is thought to be due to its ability to activate the cell surface enzymes responsible for extracellular matrix breakdown.

But then Stainier and colleagues showed that the endoderm was also somehow responsible for the migration of the heart cell buds in the layer of cells above it, known as the mesoderm.

Interneuron cell - based therapy in AD and related models: During brain development, embryonic interneuron precursors are generated in the medial ganglionic eminence (MGE) and retain a remarkable capacity for migration and integration in adult host brains, where they fully mature into functional inhibitory interneurons.

Smooth muscle cell arachidonic acid release, migration, and proliferation are markedly attenuated in mice null for calcium - independent phospholipase A2β.

Lipoapoptosis induced by saturated free fatty acids stimulates monocyte migration: a novel role for Pannexin1 in liver cells.

We further aim at deciphering the F - actin cytsokeletal dynamics of hematopoietic cells, important for migration, adhesion, homing.

Open access microfluidic device for the study of cell migration during chemotaxis.

We now have several evidences that the pattern of electrical charges depicted by corresponding molecules (e.g. glycosaminoglycans) is an important signal for the orientation and migration of cells.

Our insight will substantially enhance our understanding of dynamic cell shape regulation for instance in the context of cell migration as in cancer metastasis or during morphogenesis.

Early in his career, he discovered that previously enigmatic support cells, known as radial glia, serve as guides for the migration of cortical neurons in the developing brain, and showed how this process is critical for the organization of the multi-layered structure of the cerebral cortex.

Dendritic cells (DC) are potent antigen - presenting cells that are important for the induction of the primary immune response, including induction of T cell responses, migration, or antigen capture.

We conclude that the presence of T cells is not required for the differentiation and migration of resident skin DC but is critical for the maintenance of DC and LC migrating into the LNs.

The LG3 module of laminin - 5 harbors a binding site for integrin alpha3beta1 that promotes cell adhesion, spreading, and migration.

Researchers suspect that manipulation of vascular endothelial cell migration could be a useful therapeutic approach for those and other conditions.

RIPK2 might thus play an important role in cell migration (Wu et al., 2012), metastasis (Wu et al., 2012), and offer alternate novel therapeutics for abnormal inflammation driven by the NOD2 / RIPK2 pathway.