Sentences with phrase «for cell regulation»

«Mutations in gene essential for cell regulation cause kidney cancer in children.»

Research from Rutgers Cancer Institute of New Jersey examining difficult to treat cancer tumors through genomic profiling shows that tumors with alterations in a signaling pathway responsible for cell regulation may respond to targeted therapy regardless of where the tumor originated in the body.

Not exact matches

The wireless industry has for years successfully fought regulations that would force mobile phone networks to be hardened so they work during storms, but it may face renewed demands after Hurricane Harvey knocked out seven of 10 cell towers in the hardest - hit counties of Texas.

These vitamins are responsible for a number of bodily functions that ward off winter illness, including the regulation of T cells (or immune system warriors) and counteracting stress hormones that lower immunity.

«xIAP has other roles in the cell, such as regulation of cell death, so it is a tricky target for treating inflammatory diseases.

The spherical structure of the SNAs is the ideal architecture for delivering nucleic acids into cells for gene regulation, Mirkin said.

The study also found that in addition to its role in determining the sex of somatic cells, Sxl regulation by m6A is required to initiate germline stem cell differentiation for developing eggs.

Researchers are now zeroing in on a promising missing link: mitochondria, the cell components responsible for energy regulation.

Furthermore, regulations stipulate that each new cell line generated be independently tested and validated for safety, making it impractical to develop patient - specific cells for therapies.

NKp46 was critical for the subsequent development of antiviral and antibacterial T cell responses, which suggests that the regulation of NK cell function by NKp46 allows for the optimal development of adaptive immune responses.

BK channels are potassium ion channels found on the surface of a variety of cell types that are essential for the regulation of several key physiological processes, including smooth muscle tone and neuronal excitability.

However, Brenner, who together with two others, has just received this year's Nobel Prize in Physiology or Medicine for their discoveries concerning «genetic regulation of organ development and programmed cell death,» maintains that nothing has changed for him.

This suggests that «the python intestine may represent a valuable model for studying the interactions of metabolism with the regulation of cell division / death and WNT signaling relevant to cancer,» the researchers said.

Dr. Sade started her scientific career as a research fellow at the National Centre for Biological Sciences in Bangalore, India, where she investigated regulation of the survival and death of T cells.

«Our work suggests a mechanism for cell lethality involving the regulation of BCAAs as crucial elements in pancreatic cancer by regulating ME3,» said Ronald DePinho, M.D., professor of Cancer Biology, senior author of the Nature paper and president of MD Anderson.

We will then seek to develop the most promising of these into novel drugs for cancers, such as those of the breast, where up - regulation of this c - FLIP is believed to be important in cancer cell proliferation.»

The following year, a paper by Ben Lehner's group at the Center for Genomic Regulation in Barcelona, Spain, drove the point home: When a cell produces too many of these proteins, they found, it dies.

In 1963, the couple moved to NYU to work as immunology research fellows in the lab of Baruj Benacerraf (who shared the Nobel Prize in Physiology or Medicine in 1980 for his work on the role of genetically determined, cell - surface structures in the regulation of immune reactions).

A separate downside is that patients who have unapproved and unproven stem cell interventions decrease their chances of qualifying for FDA - cleared and IRB - approved clinical trials that comply with federal regulations.

The authors of the commentary argue that rigorous clinical testing and regulation of stem cell therapies are essential to introduce safe and effective medical interventions for patients.

In the absence of any international body that would be an obvious fit to enforce international regulations on gene editing there are historical precedents — like stem cell research — for providing guidance and then leaving the specifics up to regional authorities.

Somehow, the gene regulation responsible for proper cell development goes awry.

The researchers isolated the milk ducts and purified the breast - tissue cells to create a cell culture, which was then tested for different gene regulation profiles.

Strict drug - style regulation seems appropriate for extensively manipulated cells.

SUGAR CHECK Artificial insulin - secreting cells (shown in this false color cryo - electron microscopy image) could offer automatic, ultrafine blood sugar regulation for diabetes patients.

Even for patients who manage their insulin with automated mechanical pumps (SN Online: 5/8/10), synthetic cells offer the advantage of more precise, real time blood sugar regulation, says Michael Strano, a bioengineer at MIT.

Type 1 diabetes is an autoimmune metabolic condition in which the body kills off all the pancreatic beta cells that produce the insulin needed for glucose regulation in the body.

The results suggest that, although the lack of light chain synthesis can be due to a lack of gene rearrangement, there may also be transcriptional regulation, which may also be important for the expression of light chain immunoglobulins in immature B cells.

In most animals, nutrition involves components specialized in the regulation of nutritional supply and demand (in most animals, for example, the brain controls the needs of the body cells).

CDKs are crucial for the regulation of the cell cycle.

I don't think we need the same level of regulation as for human embryonic stem cells, for example, because we are not using any embryos.

In collaboration with the team of Eduard Sabidó at the Proteomics Unit of the Centre for Genomic Regulation and Universitat Pompeu Fabra, the researchers analyzed the proteins in Capsaspora to determine how the organism might be regulating its internal cell processes at different life stages.

«Our results with Drosophila exhibit surprising similarities in some respects to what we know about the regulation of resting phases in mammals, allowing for speculation as to whether the Hippo signaling pathway in neural stem cells functions in the same manner in both vertebrates and invertebrates,» stated the paper's first author Rouven Ding.

Joint winners of the 2002 physiology or medicine prize «for their discoveries concerning genetic regulation of organ development and programmed cell death.»

Despite this, «one 2009 estimate put the number of stem - cell companies based in China at around 100», says Doug Sipp, a stem - cell ethics and regulation researcher at the RIKEN Center for Developmental Biology in Kobe, Japan.

Telomerase is an enzyme responsible for the production of telomeres, which play an important role in the regulation of normal cell division.

When pressed, all of the stem - cell clinics approached by Nature said that they were aware of the government regulations, and that they were necessary — but only for other clinics that were not operating safely.

Fiona Doetsch's group uncovered that the choroid plexus secretes a wide variety of important signaling factors in the CSF, which are important for stem cell regulation throughout life.

Researchers from the Centre for Genomic Regulation (CRG) in Barcelona have now described a novel mechanism by which adult cells can be reprogrammed into iPS cells successfully and in a very short period of time.

A group of researchers from the Centre for Genomic Regulation in Barcelona have discovered a faster and more efficient mechanism for reprogramming induced pluripotent stem cells (iPS).

A study by Sofia J. Araújo, a Ramón y Cajal researcher with the Morphogenesis in Drosophila lab at the Institute for Research in Biomedicine (IRB), elucidates the genetic regulation of cell migration.

To peel away at the intricate layers that govern the development of neurons, a research team led by Chaolin Zhang, PhD, Assistant Professor in Systems Biology and Biochemistry and Molecular Biophysics and Hynek Wichterle, PhD, Associate Professor in Pathology & Cell Biology, Neuroscience, and Neurology, at the Center for Motor Neuron Biology and Disease, Columbia University Medical Center, focuses on a level of molecular regulation called alternative splicing.

Because RNA carries the genetic message from DNA to the cell's proteinmaking factories, or can directly perform acts such as gene regulation, it, too, is an appealing target for therapies.

Enhancers have been shown to be responsible for cell - specific gene regulation.

Researchers from Guillermo Montoya's team at the Spanish National Cancer Research Centre (CNIO), in collaboration with Isabelle Vernos» Group from the Centre for Genomic Regulation (CRG), have uncovered the molecular interaction between TACC3 and chTOG, key proteins in forming the internal cellular framework that enables and sustains cell division.

Animals need these as essential nutrients for a wide range of basic bodily chores, such as gene regulation, cell signaling and amino acid breakdown.

Taken together, these findings indicate different redox requirements for the glutathione thiol / disulfide redox couple within cytosol and mitochondria of resting cells and reveal distinct regulation of their redox poise in response to inhibition of glutathione biosynthesis.

In their study, scientists around Prof. Olivier Pertz from the Department of Biomedicine at the University of Basel gained novel insights into the regulation of directional cell migration: Using a special procedure, 20 micrometer wide lines were fabricated on glass thereby mimicking the connective tissue environment — creating a highway for cells.

His research interests are the mechanisms and regulation of chromosome segregation during mitotic cell division, and the development of software tools for accessing, processing, sharing, and publishing large scientific image datasets.

Although reducing the levels of these cells could be problematic due to their role in handling infections, he explains that the immune system generally works quite differently for the regulation of insulin resistance in obesity than it does for combating infections.