Sentences with phrase «for cell surface»

Known as MHC (Major Histocompatibility Complex) genes, they code for cell surface proteins.

This novel assay allows the simultaneous detection of up to four RNA targets in combination with immunophenotyping for cell surface and intracellular proteins using standard flow cytometry.

We have used a variety of cell models to test toxicity, cell penetration, and efficacy of furin inhibitors, and have identified small molecule inhibitors selective for cell surface furin action as well as inhibitors which also work intracellularly.

They identified these cells by looking for cell surface proteins called CD31 and CD146.

Not exact matches

His work indicates that this cell surface marker could serve as a target for a novel brain cancer vaccine or T - cell therapies engineered to recognize and kill tumors carrying that neoantigen.

After all, Panasonic has already been mass producing the older form factor 18650 cells for Model S and Model X for quite some time so any production challenges would have surfaced in the past.

At the end of September, the European Commission approved a marketing application for Lutathera, a radioactive molecule that targets specific receptors found on the surface of neuroendocrine tumor cells.

That alone makes American Tower's more than 40,000 cell towers incredibly valuable property for the next several years, but that is only scratching the surface considering the opportunities American Tower has overseas.

Vitamin A also maintains epithelial cells, which are responsible for keeping body surfaces healthy so that they can act as barriers to infection.

That is domestic violence and I was with this jerk / loser for 17 years, unknowingly attracted to him, and not even aware he was dating and screwing hookers, and living this double life, which came to the surface in 2011, and he kept cheating one after the after, begging me for mercy, but I had no where in my heart to feel anything for him, he had violated my trust, and when that trust was violated in 2011, he had nothing else left, but to continuing with his sex addiction on date sites, and on his cell phone where he never spoke to me, only told me to «shut the fuck up» even if I offered him food or a cup of tea!

This glitter decal is ideal for any smooth surface such as a cell phone cover or laptop.

These experiments were complemented by genetic manipulations in which some mice were engineered to lack a gene known as Tap1, which is crucial for the MHC I complex to make its way to the cell surface.

When similar analysis was performed on the db mice, it was found that the disrupted db gene was responsible for encoding a protein that functions as a leptin receptor: When it binds circulating leptin at the cell surface, it sets in motion a biochemical cascade inside the cell.

For the first time, researchers used human cells to build a model of the surface of the eye that's equipped with a fake eyelid that mimics blinking.

Before Krieger started tinkering with the mouse gene SCARB1, he had identified SRB1, a protein found on the surface of the liver cells, as that dock for HDL.

Further study revealed that these so - called immune proteins are actually present on the surface of certain nerve cells, but that they functioned differently in the brain than they did in the rest of the body; rather than scouting for germs, they influenced signals sent between neurons.

If scientists «start too early to specialize in biomaterials, there is a risk that they... would know all the possible applications but they will maybe not have the basis to be able to develop new ideas or new systems,» says Christine Dupont - Gillain, who leads the Nanostructured Surfaces for Cell Engineering group at the Institute of Condensed Matter and Nanosciences of the Université Catholique de Louvain in Belgium.

In this study, the SIgN team discovered for the first time that the integrity of p53 affects the production of a special cell surface protein called Major Histocompatibility Complex (MHC) class I. MHC class I molecules on the cancer cell surface serve as targets for the immune system.

BK channels are potassium ion channels found on the surface of a variety of cell types that are essential for the regulation of several key physiological processes, including smooth muscle tone and neuronal excitability.

For instance, LKB1 also helped to repress cell surface markers on immune cells called dendritic cells that fueled the allergic reaction.

Called TSH for short, this hormone attaches to a receptor on the thyroid cell surface, triggering a series of signals that provoke the gland to pump out thyroid hormones.

To begin the research, the scientists screened human DIPG tumor cultures for surface molecules that could act as targets for CAR - T cells.

Not only did the cells churn out CRH, they also harbored cell surface receptors for the hormone.

One key gene encodes the making of a receptor called TREM2, a docking site for molecules on the surface of microglia and other innate immune cells.

He determined that epithelial cells lining the brain's blood vessel walls contain a surface protein, or receptor, that can snag insulin, the hormone essential for metabolizing carbohydrates and fats.

In research that has implications for diabetes and other metabolic diseases, an international study based at UT Southwestern Medical Center found that the protein connexin 43 (Cx43) forms cell - to - cell communication channels on the surface of emerging beige fat cells that amplify the signals from those few nerve fibers.

Unlike CD8 + DCs that express the cell surface protein CD205, CD8 — DCs, which are positive for the 33D1 antigen, are specialized for presentation on major histocompatibility complex (MHC) class II.

Work is now continuing to study what transmitter substance and what receptor on the surface of the cell are responsible for the newly discovered timing mechanism.

BABY BLUE Using human eye cells, researchers fashioned an artificial eye surface that could be used to study and test treatments for eye diseases.

While displaying this behavior, the bonded platinum nanoparticles maintain an effective surface area functioning as a catalyst for chemical reactions, a discovery that could lower the production costs of platinum - catalyzed fuel cells.

MP1 interacts with lipids that are abnormally distributed on the surface of cancer cells, creating gaping holes that allow molecules crucial for cell function to leak out.

Although some cancers — particularly those that are rife with mutations like lung cancer or melanoma — create more tangible targets on the surface of cells for the immune system to recognize and attack, other malignancies such as prostate and pancreatic cancers have proved more intransigent.

Pcdhαc2 is found in a cluster of genes that contain the blueprints for proteins that protrude from the surface of cells.

A critical discovery in this research was finding that the novel progenitor has a receptor protein on its cell surface called KDR, or vascular endothelial growth factor receptor 2, which until now, was thought to be restricted to endothelial cells that form vessels, the progenitors for endothelial cells and the progenitors blood cells.

An animal's immune system detects foreign cells by scanning for proteins, called antigens, that stick out from the surface of each cell.

How it hides: In a normal cell, genes encode instructions for surface proteins known as the major histocompatibility complex (MHC).

«Cell - surface receptor offers promising breakthrough for pancreatic cancer patients.»

In 1963, the couple moved to NYU to work as immunology research fellows in the lab of Baruj Benacerraf (who shared the Nobel Prize in Physiology or Medicine in 1980 for his work on the role of genetically determined, cell - surface structures in the regulation of immune reactions).

«By determining the charge of a virus, for example, you can understand how it can be transported to the cell surface.

Researchers at Harvard T. H. Chan School of Public Health and the Broad Institute have identified a protein on the surface of human red blood cells that serves as an essential entry point for invasion by the malaria parasite.

Equally important, they developed surface molecules called integrins that are only produced when CD4 cells are destined for mucosal surfaces, such as those in the vagina.

Scientists have identified a protein on the surface of human red blood cells that serves as an essential entry point for invasion by the malaria parasite.

So his team looked for cells with vasa still on their surface in human ovarian tissue.

Some would simply crank their telomerase activity up even further; some would enhance the activity of drug - metabolizing enzymes that degrade the inhibitor; still others would change their cell surface proteins in ways that would make it harder for the drug to penetrate into the cell.

The end may already be nigh for the lander — after bouncing on the surface, the craft appears to have settled in the shadow of a wall of material, preventing it from receiving enough sunlight to its solar cells to function for more than a few days — but ESA counts the mission as a major success.

Researchers found that in N. gonorrhoeae, BamE is exposed on the cell surface but is not essential for cell viability.

«The antigens must get far enough into the cell for them to be processed, but must also return — as antigen fragments — to the surface.»

Nevertheless, as Tobias says, it is still ``... a field beset with relatively few facts but many theories... The story of early hominid brains has to be read from carefully dated, well identified, fossilised calvariae, or from endocranial casts formed within them... Such materials confine the Hercule Poirot, who would read «the little grey cells» of fossil hominids, to statements about the size, shape and surface impressions... of ancient brains...» The other major limiting factor at the moment is the lack of suitable fossil skulls for such studies.

Computer aided modeling of how the Bcl3 gene functions inside the cell allowed the group to identify a pocket on the surface of Bcl3 essential for its function.

But these fuel cells require an electrocatalyst — a platinum surface — to increase the reaction rate, and the cost of the precious metal makes it hard for hydrogen fuel cells to compete economically with the internal combustion engine.