Sentences with phrase «for cell surface proteins»

Known as MHC (Major Histocompatibility Complex) genes, they code for cell surface proteins.

They identified these cells by looking for cell surface proteins called CD31 and CD146.

Not exact matches

When similar analysis was performed on the db mice, it was found that the disrupted db gene was responsible for encoding a protein that functions as a leptin receptor: When it binds circulating leptin at the cell surface, it sets in motion a biochemical cascade inside the cell.

Before Krieger started tinkering with the mouse gene SCARB1, he had identified SRB1, a protein found on the surface of the liver cells, as that dock for HDL.

Further study revealed that these so - called immune proteins are actually present on the surface of certain nerve cells, but that they functioned differently in the brain than they did in the rest of the body; rather than scouting for germs, they influenced signals sent between neurons.

In this study, the SIgN team discovered for the first time that the integrity of p53 affects the production of a special cell surface protein called Major Histocompatibility Complex (MHC) class I. MHC class I molecules on the cancer cell surface serve as targets for the immune system.

He determined that epithelial cells lining the brain's blood vessel walls contain a surface protein, or receptor, that can snag insulin, the hormone essential for metabolizing carbohydrates and fats.

In research that has implications for diabetes and other metabolic diseases, an international study based at UT Southwestern Medical Center found that the protein connexin 43 (Cx43) forms cell - to - cell communication channels on the surface of emerging beige fat cells that amplify the signals from those few nerve fibers.

Unlike CD8 + DCs that express the cell surface protein CD205, CD8 — DCs, which are positive for the 33D1 antigen, are specialized for presentation on major histocompatibility complex (MHC) class II.

Pcdhαc2 is found in a cluster of genes that contain the blueprints for proteins that protrude from the surface of cells.

A critical discovery in this research was finding that the novel progenitor has a receptor protein on its cell surface called KDR, or vascular endothelial growth factor receptor 2, which until now, was thought to be restricted to endothelial cells that form vessels, the progenitors for endothelial cells and the progenitors blood cells.

An animal's immune system detects foreign cells by scanning for proteins, called antigens, that stick out from the surface of each cell.

How it hides: In a normal cell, genes encode instructions for surface proteins known as the major histocompatibility complex (MHC).

Researchers at Harvard T. H. Chan School of Public Health and the Broad Institute have identified a protein on the surface of human red blood cells that serves as an essential entry point for invasion by the malaria parasite.

Scientists have identified a protein on the surface of human red blood cells that serves as an essential entry point for invasion by the malaria parasite.

Some would simply crank their telomerase activity up even further; some would enhance the activity of drug - metabolizing enzymes that degrade the inhibitor; still others would change their cell surface proteins in ways that would make it harder for the drug to penetrate into the cell.

Our new device, which enables the precise manipulation and patterning of protein crystals using surface acoustic waves, is a transformative technology for structural biologists,» said Jarrod French, an assistant professor of biochemistry and cell biology at Stony Brook University.

For the study, Dr. Dadachova's team paired the monoclonal antibody (mAb2556) designed to target a protein expressed on the surface of HIV - infected cells with the radionuclide Bismuth - 213.

«The NILR1 is the genetic code for a receptor protein that is localized to the surface of plant cells and is able to bind and recognize other molecules,» says Prof. Florian Grundler, chair at the Department of Molecular Phytomedicine at the University of Bonn.

MERS CoV (CoV stands for coronavirus) has on its surface an array of spike - shaped proteins that bind to host cells — specifically to receptor proteins called DPP4 on the surface of cells that line human airways.

The ADGRE2 gene provides instructions for production of ADGRE2 protein, which is present on the surface of several types of immune cells, including mast cells.

Most resistance genes, in wheat and other plants, code for protein receptors located inside cells; the Stb6 gene codes for a receptor protein on the cell's surface.

That makes them of similar size as many viruses, enabling the particles to enter cells by exploiting the same surface proteins that viruses use for this purpose.

This in vivo reconstitution system provides a new approach for examining ligand binding and G protein coupling to cell surface receptors.

In clinical trials already underway, for example, researchers have used an older gene - editing technique, enzymes call zinc finger nucleases, in immune cells to deactivate the gene for CCR5, a surface protein that HIV latches onto in order to infect cells.

In addition, Berger's team has identified two surface proteins located on the neural stem cells and the surrounding niche glial cells that are responsible for the interactions between these cells.

While the simple proteins called histatins are well known for their ability to ward off infections, biochemist Menno Oudhoff of the University of Amsterdam discovered a subset of histatins that also prompt cells from the skin's surface, called the epithelium, to close over a wound.

For example, the aquaporin protein - mediated flow of water across biological cell membranes is down to a balance between hydrophobic and hydrophilic interactions with channel surfaces.

They have screened combinations of antibodies that bind to specific proteins on the surface of the immature and mature stem cells and that can be used for flow cytometry, a common laboratory technique for sorting cells.

Traditional methods for sorting cells rely on fluorescent molecular tags, designed to stick to the surface proteins present on certain types of cells but not on others.

Karl Deisseroth of Stanford University, and colleagues, inserted into mice the gene which codes for the algal protein ChR2, which caused the protein to attach itself to the surface of nerve cells.

For example, Dr. Shiloh said, preventing Mtb from attaching to receptors on the M - cell surface — such as by vaccinating against a bacterial protein — could block the bacteria's entry, infection, and spread to other organs.

The findings suggest that reductions in the number of cartilage - producing cells, and greater risk for osteoarthritis, may be driven not just by lower adenosine levels but also by lower levels of the protein on the surface of chondrocytes designed to receive and pass on adenosine's signal.

Bartenschlager injected this «replicon,» which codes for HCV's nonstructural proteins but not its core or surface proteins, into human cells.

Until now, the Rh proteins that dot the surface of red blood cells were known for the problems they can cause for blood transfusions and pregnancy.

A CFTR protein with this mutation can not fold properly and can not navigate its way to the surface of the cell where it would normally reside, providing a channel for chloride to flow in and out.

Both genes code for proteins that function as growth factor receptors, meaning they sit on the surface of cells and, when activated, can spur the rapid cell growth that is a hallmark of cancer.

Receptors are proteins that are usually located on the external surface of the cell membrane; they provide specific recognition sites for messenger substances such as hormones, neurotransmitters and growth factors.

«The genetic changes in these cells lead to protein changes on the cells» surface which make them an excellent target for a person's immune system to react to,» says Gan.

The scientists also found that a protein known as CD29 acts as a cell - surface marker for precursor fat cells that can generate mature cells with high energy potential, as shown by their UCP1 expression.

Researchers in the laboratory of Richard A. Axel, including Leonard Chess and Dan Littman, clone the genes for the CD4 [i] and CD8 [ii] T cell surface proteins.

Timothy Springer, with colleagues Michael L. Dustin and Charles A. Dinarello, identifies and characterizes adhesion molecules, a class of cell surface proteins that function in the interactions of immune cells with other cells, including antigen - specific recognition and cell trafficking: integrin LFA - 1 involved in cytoskeleton and signaling, and intracellular adhesion molecules (ICAMs), which are binding partners (ligands) for LFA - 1 and are increased in inflammatory and autoimmune disease.

A conserved motif for the transport of G protein - coupled receptors from the endoplasmic reticulum to the cell surface.

The BMP protein acts as an activator for cell — surface receptors, and initiates cellular processes and signaling cascades.

The system could be used for analyzing low expression cell surface proteins and for high - throughput screening for industrial enzyme production.

This collaboration led to the discovery of distinct behavioral changes that occur in the motions of individual proteins on the surface of cells, thereby helping elucidate what it means for the pathway to be active or inactive.

BST - 2 is rapidly down - regulated from the cell surface by the HIV - 1 protein Vpu: evidence for a post-ER mechanism of Vpu - action.

The vaccines deliver mRNA encoding for hemagglutinin to the body's cells, directing them to produce and express this viral antigenic protein transiently on the cell's surface, much like a native infection would do, but without the ability to cause disease.

Miller said that other proteins anchored to the cell surface in a similar fashion are known to play roles in cell proliferation, suggesting a possible mechanism for how HYAL2 might be involved in tumor formation.

A cell - surface antibody panel was created and used for protein profiling alongside gene expression profiling.