Sentences with phrase «for cellular development»

Not exact matches

And there have been developments in cellular therapies to treat cancer, with two treatments aiming for approval by the end of 2017.

The disruption of prenatal cellular activity in zebra fish, which share 80 percent of their genes with humans and are considered a good model for studying human brain development, seemed to result in hyperactivity, according to the Canadian study, which was published Monday in the Proceedings of the National Academy of Sciences.

Close collaboration between the Pasteur Institute and Inria, taking the form of the InBio join research group, whose aim is to develop a methodological framework for achieving a quantitative understanding of the functioning of cellular processes, is the perfect illustration of the value of interdisciplinary research combining experimental approaches with methodological developments.

In conclusion, this new study identifies the cellular origin of Pik3ca - induced tumours and reveals that oncogenic Pik3ca activates a multipotent genetic program, setting the stage for future intratumoural heterogeneity at the earliest stage of tumor development.

Now, in this week's issue of the Proceedings of the National Academy of Sciences, Thomas Albright and Ricardo Gil - da - Costa of the Salk Institute for Biological Studies describe a model system that completes the bridge between cellular and human studies of schizophrenia, an advance that should help speed the development of therapeutics for schizophrenia and other neurological disorders.

Cancer cells are opportunistic in the sense that they hijack cellular events necessary for development and survival.

The use of MRI for research, rather than diagnostic, purposes is a relatively new development, and clinical investigators in the imaging community often do not understand the basic cellular and neural circuitry issues as well as they should, he says.

Those deletions tended to involve genes that affect cilia, cellular structures that are important for signaling and patterning in embryonic development.

Meanwhile, cancer genome projects have yielded unprecedented insights into the cellular signaling pathways that drive the development and progression of cancer — information that has led to effective therapies tailored for individual patients.

For example, such an approach might eventually form the basis for treating the most common cause of infertility — the failure of the embryo to successfully implant — or for affecting the cellular changes that lead to the development of cancFor example, such an approach might eventually form the basis for treating the most common cause of infertility — the failure of the embryo to successfully implant — or for affecting the cellular changes that lead to the development of cancfor treating the most common cause of infertility — the failure of the embryo to successfully implant — or for affecting the cellular changes that lead to the development of cancfor affecting the cellular changes that lead to the development of cancer.

Professor Fallon said: «This identification of an early stage cellular checkpoint that can act as a break on allergic responses has important implications for the development of new therapeutic approaches for asthma and other allergic diseases.»

«Bacteria development marks new era in cellular design: Scientists have built a miniature scaffold inside bacteria that can be used to bolster cellular productivity, with implications for the next generation of biofuel production.»

As researchers at the Max Planck Institute of Biochemistry report in the current issue of Nature, they have now decoded a new cellular mechanism for the development of aggregates.

This finding is an important step towards a better understanding of the cellular and molecular underpinnings of addictive behavior, paving the way for the development of effective therapeutics.

This routine cellular maintenance is important for normal brain development.

A number of studies have shown that miRNAs are critical for normal development and cellular growth and may contribute to the complexity of neurodegenerative diseases.

The finding is anticipated to help in the search for causes of kidney disease, new drug development, and other cellular research.

He also envisions that this kind of nanomechanical phenotyping should allow for the development of predictive models for cellular behavior for any kind of cell.

He said: «Our study has shown for the first time the evidence that local anaesthetic may affect the development of children's teeth in cellular and molecular levels.

Traditional hydrogels made up of either synthetic polymers or natural biomolecules often serve as passive scaffolds for molecular or cellular species, which render these materials unable to fully recapitulate the dynamic signaling involved in biological processes, such as cell / tissue development.

Only from these results can the team deduce which conditions are crucial for the development of complex life and whether Earth is the ideal place for the necessary cellular processes.

«We were able to use a set of cutting - edge tools to gain insight into a critical cellular process for normal brain development, the dysregulation of which may be a manifestation of a genetic predisposition for schizophrenia,» says senior author Dr. Guo - li Ming, of Johns Hopkins University School of Medicine.

«The development of this microfluidic lung model, as well as other organs - on - chip, holds the promise of improving the physiological relevance of cellular models for more accurate prediction of the effects of toxicants and drugs on humans, and for reducing the use of animals in medical and pharmaceutical research,» said Sonia Grego, Ph.D., research scientist at RTI and the project's principal investigator.

It is caused by a mutation in the ACVR1 gene, which over-activates a cellular signaling process that is important for embryo development and involves a protein called BMP.

These include, for example, the mechanisms behind stem - cell development and what happens when normal cellular growth spirals out of control, such as in cancer.

Dr. Subramaniam is head of database developments under The Alliance for Cellular Signaling, a multi-institution, multidisciplinary project, utilizing a multitude of high throughput approaches to obtain context - specific knowledge of cellular response to input.

For 2018, the CIMT program committee is preparing plenary sessions from pre-clinical research to clinical development on the topics of therapeutic vaccination, cellular therapy, improving immunity, tumor microenvironment, antibodies, regulatory research and immunoguiding.

The research of the department focuses on the development of cryo - electron tomography which is widely seen now as a method of unique potential for visualizing macromolecular complexes in their functional cellular context.

The lab focuses on clarifying the mechanisms of brain plasticity, gene expression, and responses of cellular elements to different psychotropic drugs, and have identified several novel brain sites and pathways that constitute attractive targets for new drug development.

Our research goal is to understand the molecular and cellular events required for pancreatic β - cell regeneration, and apply this knowledge towards the development of cell replacement therapies for diabetes.

One new way that scientists study this process of cellular development — and a way in which they hope to grow replacement tissue for medical treatments in the future — is by recreating the essential features of human brains, eyes, lungs, and guts in a petri dish.

LifeMap Discovery ® is a compendium of embryonic development for stem cell research and regenerative medicine, constructed by integrating extensive molecular, cellular, anatomical and medical data curated from scientific literature and high - throughput data sources.

Our ultimate goals in this activity include (1) a better understanding of the molecular mechanisms governing cellular processes and especially those involved in certain kinds of diseases such as cancer and (2) the development of computational tools that can be used for diagnostic / prognostic purposes based on genomic data.

The Cancer, Ageing and Somatic Mutation Programme seeks to provide leadership in data aggregation and informatics innovation, developing high - throughput cellular models of cancer for genome - wide functional screens and drug testing, and exploring basic scientific questions about the role somatic mutation plays in clonal evolution, ageing and development.

However, until an AMA1 malaria vaccine demonstrates clinical efficacy against genetically diverse natural parasites, the relevance of growth inhibition assays and other humoral and cellular immunogenicity endpoints for clinical development decisions will remain a matter of reasoned conjecture.

Autophagy is a cellular process that plays an important role during the development and maintenance of tumors, providing them with the metabolic plasticity to meet their energetic needs, and requirements for cellular building blocks.

The cellular processes that we have identified in this study as being important for the development of stomach cancer provide new targets for therapy that have not been explored before,» Dr. O'Reilly said.

Areas covered by Cancer Cell include, but are not limited to, molecular and cellular mechanisms of cancer, mechanisms for the sensitivity and the resistance to cancer therapies, and development of better cancer therapies.

You will be responsible for the development of immune assays to facilitate the assessment of responses post nairovirus exposure, including assessment of both cellular and humoral immunity.

Our company focuses on the development of innovative immunotherapies for cancer based on genetically engineered lymphocytes and cellular components of the tumor microenvironment.

Since joining Widener, I have worked closely with undergraduate students to continue investigating genetic and cellular mechanisms important for nervous system development in fruit flies.

These results shed light on how methylation affects motor neuron development and lay the framework for future studies on how methylation dynamics determine cellular fate.

For example, the same cellular signals that guide early heart development can be used to direct stem cells to become the different heart cell types needed for modeling disease in a diFor example, the same cellular signals that guide early heart development can be used to direct stem cells to become the different heart cell types needed for modeling disease in a difor modeling disease in a dish.

It is poised to become a major site for research and early development of personalized cellular therapies for cancer.

Setton also identified a gene, called arrow, that when disrupted set off a cascade of cellular signaling events suggesting for the first time important relationships between segmentation and leg - development genes found across insects and arachnids.

For example, assaying the genomes of multiple cells during development reveals developmental lineage trees - the kinship lineage - whereas cellular transcriptomes inform us about the regulatory state of cells and their gradual restriction in potency - the Waddington lineage.

Now researchers at the Salk Institute for Biological Studies have identified an essential cellular pathway in zebrafish that paves the way for limb regeneration by unlocking gene expression patterns last seen during embryonic development.

His laboratory at Stanford University School of Medicine is developing novel stem cell and nanotherapeutics approaches for ocular repair, studying retinal ganglion cell development, survival and axon regeneration in glaucoma, and investigating the cellular basis for the developmental loss of axon growth ability.

The microRNA miR - 181 is a critical cellular metabolic rheostat essential for NKT cell ontogenesis and lymphocyte development and homeostasis.

1) Phytonutrients: * Occur naturally in fruits and vegetables * Promote the function of the immune system * Help fight off viruses as well as reduce inflammation * Associated with the treatment and / or prevention of cancer and cardiovascular disease 2) Enzymes: * Responsible for metabolic processes that occur within a cell and are necessary for sustaining life * Assist and play a large role in digestion, energy production, blood coagulation and contraction of muscles 3) Amino Acids: * The basic building blocks of protein * Absorption of amino acids is essential for your metabolism 4) Essential Fatty Acids: * Reduce the risk of heart disease and some forms of cancer * Improve mood * Decrease inflammation 5) Vitamins: * Essential for the normal growth and development of all human beings * Healthy maintenance of cell tissues and organs * Help process proteins, carbohydrates and fats required for utilization 6 & 7) Macro and Trace Minerals: * Involved in electrolyte balance of body fluids * Essential for normal cellular activity * Provide hardness to bones and teeth